A comparison of paracervical block with single-shot spinal for labour analgesia in multiparous women: a randomised controlled trial

Junttila, Eija; Karjalainen, P; Ohtonen, Pasi; Raudaskoski, Tytti; Ranta, P.

doi:10.1016/j.ijoa.2008.01.020

Cited by 23 publications

(15 citation statements)

References 31 publications

(34 reference statements)

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“…121,62 A randomized comparison of single-shot spinal analgesia using low-dose bupivacaine-sufentanil and paracervical block using bupivacaine alone showed that analgesia was better in the spinal group, but umbilical artery pH was significantly lower. 122 This adverse effect could be laid at the door of intrathecal sufentanil, but equally it is consistent with a significant detrimental effect on funic acid-base balance of spinal compared with general and epidural anaesthesia for caesarean section. 123 …”

Section: Variations In Neuraxial Techniquesmentioning

confidence: 70%

Labour analgesia and the baby: good news is no news

Reynolds

2011

International Journal of Obstetric Anesthesia

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Section: Variations In Neuraxial Techniquesmentioning

confidence: 70%

Labour analgesia and the baby: good news is no news

Reynolds

2011

International Journal of Obstetric Anesthesia

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“…[1011] Sufentanil is a short synthetic μ-opioid analgesic characterized by good potency and negligible cardiovascular effects. [1213] Furthermore; sufentanil TCI provides stable analgesia, better hemodynamic control and anticipated recovery from anesthesia. [1415] The present study was designed to determine the optimal effect-site concentration (Ce) of sufentanil in providing successful LMA insertion when given with a TCI of propofol at 4.0 μg/mL as the primary outcome and to assess the incidence and severity of injection pain of propofol as a secondary outcome.…”

Section: Introductionmentioning

confidence: 99%

The optimal effect-site concentration of sufentanil for laryngeal mask insertion during induction with target-controlled propofol infusion at 4.0 μg/mL

Al-Metwalli

2014

Saudi J Anaesth

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Objective:The objective of this study is to determine the optimal effect-site concentration (Ce) of sufentanil for satisfactory insertion of laryngeal mask airway (LMA) when administered with a target-controlled infusion (TCI) of propofol at 4.0 μg/mL.Materials and Methods:A total of 25 adult patients scheduled for minor elective surgery were enrolled in this study. All patients received induction with a combination of propofol and sufentanil TCI. The TCI of sufentanil was started at a target Ce of 0.1 ng/mL. After equilibrium with the plasma concentration, the TCI of propofol was initiated, targeting a preset Ce of 4.0 μg/mL. After the loss of consciousness, LMA was inserted and assessed by an experienced Anesthesiologist. The Ce of sufentanil for the next patient was guided by modified Dixon's up-and-down method using 0.05 ng/mL as a step size. The Ce of sufentanil required for successful LMA insertion in 50% of adults (EC50) was determined by calculating the midpoint concentration of all independent pairs of patients after at least seven crossover points.Results:The optimal Ce (EC50) of sufentanil for LMA insertion during propofol induction using target Ce of 4 μg/mL was 0.16 ng/mL (95% confidence interval [CI] = 0.12-0.20). There was a significant reduction in propofol induced pain score P = 0.0275 and insignificant hemodynamic changes.Conclusion:Ce of sufentanil required for successful LMA insertion in 50% of patients (EC50) using propofol target Ce of 4.0 μg/mL was 0.16 ng/mL (95% CI = 0.12-0.20) with a significant reduction in the propofol induced pain and hemodynamic stability.

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“…It is possible that these women had made a definite decision to go through labor without analgesia, and thus their expectations and experience of childbirth were in line. Still, in general, compared with other analgesic options or no analgesia at all, epidural or combined epidural/spinal analgesia during labor and delivery results in better reduction and control of the pain and thus better satisfaction . The inconsistent relation between perceived pain and received analgesia emphasizes the subjective nature of an experience.…”

Section: Discussionmentioning

confidence: 99%