A comparison of photodynamic therapy using topical methyl aminolevulinate (Metvix ® ) with single cycle cryotherapy in patients with actinic keratosis: a prospective, randomized study

Freeman, M; Vinciullo, C; Francis, David M.; Spelman, Lynda; Nguyen, Richard D.; Fergin, Peter; Thai, K-E; Murrell, Dédée F.; Weightman, Warren; Anderson, Chris; Reid, C; Watson, A; Foley, Peter

doi:10.1080/09546630305538

Cited by 84 publications

(161 citation statements)

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“…57,58 After local reactions have healed (mostly erythema and crusting), cosmesis is generally excellent. 59,60 PDT systems offer reasonable options for AKs disseminated over large areas. In more advanced AKs, curettage is generally required before PDT to remove hyperkeratotic tissue.…”

Section: Pdt and Daylight Pdtmentioning

confidence: 99%

Non-melanoma Skin Cancer in Canada Chapter 3: Management of Actinic Keratoses

et al. 2015

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Background Actinic keratosis (AK) and cheilitis (AC) are lesions that develop on photodamaged skin and may progress to form invasive squamous cell carcinomas (SCCs). Objective To provide guidance to Canadian health care practitioners regarding management of AKs and ACs. Methods Literature searches and development of graded recommendations were carried out as discussed in the accompanying introduction (chapter 1 of the NMSC guidelines). Results Treatment of AKs allows for secondary prevention of skin cancer in sun-damaged skin. Because it is impossible to predict whether a given AK will regress, persist, or progress, AKs should ideally be treated. This chapter discusses options for the management of AKs and ACs. Conclusions Treatment options include surgical removal, topical treatment, and photodynamic therapy. Combined modalities may be used in case of inadequate response. AKs are particularly common following the longterm immunosuppression in organ transplant patients, who should be monitored frequently to identify emerging lesions that require surgery.

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Section: Pdt and Daylight Pdtmentioning

confidence: 99%

Non-melanoma Skin Cancer in Canada Chapter 3: Management of Actinic Keratoses

et al. 2015

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“…At 3 months complete remission was reported in 91% of the patients that underwent PDT, 68% with cryotherapy, and 30% of patients who received placebo. The cosmetic results were excellent in 81% of the patients treated with PDT and in only 51% of the cases that received cryotherapy (Freeman et al, 2003). In the US, a randomized, double-blind, placebo controlled, multicentric study on 80 patients with AK treated with MAL-PDT in two sessions with red light (75 J/cm 2 ) found a complete remission in 89% of the cases compared to placebo (38%), with excellent cosmetic results in 90% of the cases.…”

Section: Premalignant Lesionsmentioning

confidence: 98%

Photodynamic Therapy in Skin Cancer

Clichici¹,

Filip²

2011

Skin Cancers - Risk Factors, Prevention and Therapy

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“…[13][14][15][18][19][20][21] PDT has therefore been classified as a treatment option with good therapeutic selectivity, significant cure rates, good tolerability and favorable cosmetic results. Furthermore, it allows larger areas of the body to be treated, thereby enabling multiple actinic keratoses and areas affected by cancer to be treated simultaneously.…”

Section: Discussionmentioning

confidence: 99%

Terapêutica fotodinâmica com ácido delta-aminolevulínico e luz de diodos em ceratoses actínicas

Ritter

Kuhl

Lenhardt

et al. 2010

An. Bras. Dermatol.

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BACKGROUND: Photodynamic therapy is a form of treatment in which a photosensitizing substance is applied to tissue and activated by a light source at a specific wavelength, thus selectively destroying cells. New light sources are being evaluated for use in the treatment of actinic keratoses. OBJECTIVES: To evaluate the efficacy of photodynamic therapy with delta-aminolevulinic acid using a light emitting diode device as a light source in the treatment of actinic keratoses of the face and upper limbs. METHODS: Eighteen patients with actinic keratoses of the face or upper limbs received an application of a 20% delta-aminolevulinic acid cream and were submitted to diode light irradiation at a wavelength of 630 nm. RESULTS: A total of 328 actinic keratoses were treated, obtaining complete cure in 210 (64.0%) after 24 weeks. Lesions situated on the back of the hands were clinically cured in 49.2% of cases compared to 81.4% in the cases of lesions in other areas. There was no record of any severe adverse effects and patient satisfaction with the results was high. CONCLUSION: Photodynamic therapy with a diode light emitting source proved effective and well-tolerated for the treatment of actinic keratoses, with results similar to those reported in the literature with other light sources. Keywords: Keratosis; Photobiology; Photochemotherapy Resumo: FUNDAMENTOS: A terapêutica fotodinâmica é técnica de tratamento em que se aplica uma substân-cia fotossensibilizante nos tecidos ativada por uma fonte de luz de comprimento de onda específico, gerando destruição celular seletiva. Estudam-se novas fontes de luz que possam ser usadas no tratamento de ceratoses actínicas. OBJETIVOS: Avaliar a efetividade da terapêutica fotodinâmica com ácido delta-aminolevulínico utilizando como fonte de luz um aparelho emissor de luz de diodos no tratamento de ceratoses actínicas de face e membros superiores. MÉTODOS: Dezoito pacientes com ceratoses actínicas na face ou membros superiores realizaram uma aplicação de creme de ácido delta-aminolevulínico a 20% e foram submetidos à exposição de luz de diodos, comprimento de onda de 630 nm. RESULTADOS: Foram tratadas 328 ceratoses actínicas, obtendo-se cura clínica completa em 210 (64,0%) após 24 semanas. Lesões do dorso das mãos apresentaram cura clínica completa em 49,2%; nas demais áreas esse valor foi de 81,4%. Não houve registro de efeitos adversos graves, e obteve-se bom grau de satisfação dos pacientes com os resultados. CONCLUSÃO: A terapêutica fotodinâmica com fonte de emissão de luz de diodos mostrou-se eficaz e bem tolerada para tratamento de ceratoses actínicas, com resultados semelhantes aos encontrados na literatura utilizando outras fontes luminosas.

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A comparison of photodynamic therapy using topical methyl aminolevulinate (Metvix ® ) with single cycle cryotherapy in patients with actinic keratosis: a prospective, randomized study

Cited by 84 publications

References 0 publications

Non-melanoma Skin Cancer in Canada Chapter 3: Management of Actinic Keratoses

Non-melanoma Skin Cancer in Canada Chapter 3: Management of Actinic Keratoses

Photodynamic Therapy in Skin Cancer

Terapêutica fotodinâmica com ácido delta-aminolevulínico e luz de diodos em ceratoses actínicas

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