A Comparison of Pregnancy Experience in DES-Exposed and DES-Unexposed Daughters

Herbst, Arthur L.; Hubby, Marian M.; Blough, Richard R.; Azizi, Freidoon

doi:10.1097/00006254-198007000-00023

Cited by 20 publications

(24 citation statements)

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“…A sentinel example of developmental programming in humans is the use of diethystilbestrol (DES) by pregnant women in the attempt to prevent miscarriage. Later, it was found that maternal DES use increased the risk of reproductive tract abnormalities, vaginal and breast cancer, spontaneous abortion, and stillbirth in DES daughters whose mothers took DES during pregnancy (160,161). DES sons also experienced long-term negative health impacts.…”

Section: Birth Defects and Developmental Origins Of Health And Diseasementioning

confidence: 99%

Developmental and reproductive effects of chemicals associated with unconventional oil and natural gas operations

Webb

Bushkin-Bedient²,

Cheng

et al. 2014

Reviews on Environmental Health

143

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AbstractUnconventional oil and gas (UOG) operations have the potential to increase air and water pollution in communities located near UOG operations. Every stage of UOG operation from well construction to extraction, operations, transportation, and distribution can lead to air and water contamination. Hundreds of chemicals are associated with the process of unconventional oil and natural gas production. In this work, we review the scientific literature providing evidence that adult and early life exposure to chemicals associated with UOG operations can result in adverse reproductive health and developmental effects in humans. Volatile organic compounds (VOCs) [including benzene, toluene, ethyl benzene, and xylene (BTEX) and formaldehyde] and heavy metals (including arsenic, cadmium and lead) are just a few of the known contributors to reduced air and water quality that pose a threat to human developmental and reproductive health. The developing fetus is particularly sensitive to environmental factors, which include air and water pollution. Research shows that there are critical windows of vulnerability during prenatal and early postnatal development, during which chemical exposures can cause potentially permanent damage to the growing embryo and fetus. Many of the air and water pollutants found near UOG operation sites are recognized as being developmental and reproductive toxicants; therefore there is a compelling need to increase our knowledge of the potential health consequences for adults, infants, and children from these chemicals through rapid and thorough health research investigation.

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Section: Birth Defects and Developmental Origins Of Health And Diseasementioning

confidence: 99%

Developmental and reproductive effects of chemicals associated with unconventional oil and natural gas operations

Webb

Bushkin-Bedient²,

Cheng

et al. 2014

Reviews on Environmental Health

143

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“…En revanche, l'effet-dose ne semble pas intervenir sur l'apparition des malformations [7]. On peut ainsi noter un retentissement cervico-vaginal ; adénose cervico-vaginale, hypoplasies cervicales, diaphragmes vaginaux, bourrelets vaginaux, petits cols coniques, cols avec des crêtes de coq, aspects pseudopolypoïdes, replis annulaires ou transversaux, orifice externe déformé en S, Y, ou T [6,8]. Un retentissement utérin s'observe également (anomalies de forme et de taille : utérus en T, hypoplasie de la cavité, cloisons utérines, sténose médio cavitaire, utérus bicorne uni cervical).…”

Section: Introductionunclassified

Amélioration du pronostic obstétrical des femmes porteuses d’un utérus distilbène par une prise en charge adaptée

Amour

Mokdad

Mayenga

et al. 2004

Gynécologie Obstétrique & Fertilité

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“…It is also not apparent whether the reproductive tract of such progeny would be favourable for early embryonic development and ova transport. Answers to these questions are important since increased infertility (Herbst et al, 1980;Stillman, 1982), spontaneous abortions (Herbst et al, 1980;Barnes et al, 1980) and ectopie pregnancies (Cousins et al, 1980;Berger & Goldstein, 1980) have been reported in women exposed to diethylstilboestrol during gestation. The objectives of this study were to (1) ascertain whether the ovaries from progeny of mice exposed to diethylstilboestrol could respond to exogenous gonadotrophins, (2) establish whether ovulated ova from diethylstilboestrol-exposed mice were capable of fertilization and (3) utilize in-vitro and in-vivo techniques to examine early embryonic development of second generation progeny from such animals.…”

Section: Introductionmentioning

confidence: 99%

Superovulation and early embryo development in the adult mouse after prenatal exposure to diethylstilboestrol

Wordinger

Brown²,

Craig-Atkins³

et al. 1989

Reproduction

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Pregnant mice were injected subcutaneously with diethylstilboestrol (DES: 10 micrograms/kg body weight in 0.1 ml corn oil) or corn oil alone on Day 15 or 16 of gestation (Day 1 = day of copulatory plug) and allowed to give birth. Female progeny from control and DES-exposed animals were superovulated with exogenous gonadotrophins at 6-8 weeks of age. In-vivo results indicated that the total number of ovulated ova, 2-cell embryos and blastocysts were significantly increased in DES-exposed progeny but that there was a decline in developmental potential from the ovulated ova stage to the blastocyst stage in these animals. However, there was no significant difference in the in-vitro development of 2-cell embryos to the blastocyst stage between control and DES-exposed animals. These results indicate that the ovaries of mice exposed in utero to DES are capable of responding to exogenous gonadotrophins and that second generation progeny have the potential for normal development to the early postblastocyst stage of embryogenesis. The in-vivo decline in developmental potential may be attributable to reproductive tract abnormalities rather than ova/embryo defects.

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A Comparison of Pregnancy Experience in DES-Exposed and DES-Unexposed Daughters

Cited by 20 publications

References 0 publications

Developmental and reproductive effects of chemicals associated with unconventional oil and natural gas operations

Developmental and reproductive effects of chemicals associated with unconventional oil and natural gas operations

Amélioration du pronostic obstétrical des femmes porteuses d’un utérus distilbène par une prise en charge adaptée

Superovulation and early embryo development in the adult mouse after prenatal exposure to diethylstilboestrol

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