A comparison of prenatal versus postnatal karyotyping for the investigation of intrauterine fetal death after the first trimester of pregnancy

Abstract

Invasive testing has a much higher success rate of karyotyping in cases of IUFD and should, therefore, be offered to women presenting with this complication irrespective of gestational age.

Genetics of Stillbirth

“…4,25,26 Most studies show that due to difficulty with tissue culture because of contamination and maceration, fetal tissue karyotype fails from 30% to 60% of the time. This should start at the time the stillbirth is identified and if possible should not wait until after delivery as information can be lost.…”

Intrauterine fetal demise after prenatal diagnosis of congenital heart disease: assessment of risk

“…The risk of IUFD in the general population is 1/160 (0.6%) pregnancies . The fetus with genetic and structural anomalies, including CHD, is said to be at increased risk for intrauterine fetal demise (IUFD) . Previous publications have noted up to a 20% incidence of genetic and extra‐cardiac anomalies (ECA) in the fetus with CHD .…”

Late intrauterine fetal death and stillbirth

“…patella, but cartilage is harder to sample. 87 Amniocentesis can also provide cytogenetic results if the mother chooses expectant management, 1,71,73,74 but patient acceptability and safety (infection) of amniocentesis has not been investigated in this setting.…”