A Comparison of Prognoses of Pathologic Stage Ib Adenocarcinoma and Squamous Cell Carcinoma of the Uterine Cervix

Nakanishi, Tōru; Ishikawa, Hisatake; Suzuki, Yuka; Inoue, Tatsuya; Nakamura, Shigeo; Kuzuya, Kazuo

doi:10.1006/gyno.2000.5935

Cited by 127 publications

(122 citation statements)

References 17 publications

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“…Regardless of stage, SNEC was associated with poorer survival compared with ADC and SCC while patients with ADC had a poorer survival than SCC, Asian Pacific Journal of Cancer Prevention, Vol 14, 2013 5359 DOI:http://dx.doi.org/10.7314/APJCP.2013.14.9.5355 Prognostic Impact of Histology in Patients with Cervical Cancer in the intermediate-risk group, while no significant difference was found in the low-risk group [95.9% vs. 99.1%, respectively (P=0.100)] (Mabuchi et al, 2012). In agreement with these finding, other studies have reported poorer survival only among early-stage patients with ADC who have lymph node metastasis compared with those with SCC (Nakanishi et al, 2000;Takeda et al, 2002;Rudtanasudjatum et al, 2011) while another study demonstrated a poorer survival of early-stage patients with ADC even though the clinical and pathological factors between the two groups were comparable (Park et al, 2010). In line with our findings, Fregnani et al (2008) found no significant difference in survival between earlystage patients with ADC and SCC with 5-year disease-free survival of 87.9% and 85.7% (p=0.488), respectively.…”

Section: Discussionsupporting

confidence: 71%

“…Several studies have reported that histological type is an important prognostic factor (Nakanishi et al, 2000;Takeda et al, 2002;Vinh-Hung et al, 2007;Chen et al, 2008;Zivanovic et al, 2009;Lee et al, 2010;Park et al, 2010). A US study of patients from 1997 to 2003 in the SEER database found 5-year overall survivals of 32.5% for patients with SNEC, 74.3% for ADC and 64.6% for SCC (Chen et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

“…A US study of patients from 1997 to 2003 in the SEER database found 5-year overall survivals of 32.5% for patients with SNEC, 74.3% for ADC and 64.6% for SCC (Chen et al, 2008). Some studies have reported 2.6-2.9 times higher mortality among patients with early stage ADC compared with early-stage SCC patients over 10-19 years of follow-up (Nakanishi et al, 2000;Takeda et al, 2002;Park et al, 2010;Mabuchi et al, 2012) while others have not found any significant difference in survival among patients with SCC and ADC (Shingleton et al, 1995;Lee et al, 2006;Fregnani et al, 2008;Kasamatsu et al, 2009;Narukon et al, 2010). Moreover, only few studies have included patients with SNEC.…”

Section: Introductionmentioning

confidence: 99%

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Prognostic Impact of Histology in Patients with Cervical Squamous Cell Carcinoma, Adenocarcinoma and Small Cell Neuroendocrine Carcinoma

Intaraphet

Kasatpibal²,

Siriaunkgul³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Cervical cancer is the third most common cancer among women worldwide, accounting for approximately 13% of all cancers in women, with 529,800 new cases and 275,100 deaths in 2008. More than 85% of the cases and about 88% of all deaths occurred in developing countries (Ferlay, 2010;Jemal et al., 2011). At the same time, the incidence of cervical cancer has decreased dramatically in developed countries with well-developed screening programs concomitant with substantial survival AbstractBackground: Clarifying the prognostic impact of histological type is an essential issue that may influence the treatment and follow-up planning of newly diagnosed cervical cancer cases. This study aimed to evaluate the prognostic impact of histological type on survival and mortality in patients with cervical squamous cell carcinoma (SCC), adenocarcinoma (ADC) and small cell neuroendocrine carcinoma (SNEC). Materials and Methods: All patients with cervical cancer diagnosed and treated at Chiang Mai University Hospital between January 1995 and October 2011 were eligible. We included all patients with SNEC and a random weighted sample of patients with SCC and ADC. We used competing-risks regression analysis to evaluate the association between histological type and cancer-specific survival and mortality. Results: Of all 2,108 patients, 1,632 (77.4%) had SCC, 346 (16.4%) had ADC and 130 (6.2%) had SNEC. Overall, five-year cancer-specific survival was 60.0%, 54.7%, and 48.4% in patients with SCC, ADC and SNEC, respectively. After adjusting for other clinical and pathological factors, patients with SNEC and ADC had higher risk of cancer-related death compared with SCC patients (hazard ratio [HR] 2.6; 95% CI, 1.9-3.5 and HR 1.3; 95% CI, 1.1-1.5, respectively). Patients with SNEC were younger and had higher risk of cancer-related death in both early and advanced stages compared with SCC patients (HR 4.9; 95% CI, 2.7-9.1 and HR 2.5; 95% CI, 1.7-3.5, respectively). Those with advanced-stage ADC had a greater risk of cancer-related death (HR 1.4; 95% CI, 1.2-1.7) compared with those with advanced-stage SCC, while no significant difference was observed in patients with early stage lesions. Conclusion: Histological type is an important prognostic factor among patients with cervical cancer in Thailand. Though patients with SNEC were younger and more often had a diagnosis of early stage compared with ADC and SCC, SNEC was associated with poorest survival. ADC was associated with poorer survival compared with SCC in advanced stages, while no difference was observed at early stages. Further tailored treatment-strategies and follow-up planning among patients with different histological types should be considered.

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Section: Discussionsupporting

confidence: 71%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prognostic Impact of Histology in Patients with Cervical Squamous Cell Carcinoma, Adenocarcinoma and Small Cell Neuroendocrine Carcinoma

Intaraphet

Kasatpibal²,

Siriaunkgul³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…Previous studies either usually lacked sufficient numbers of patients with adenocarcinomas (Pilch et al, 2001), or were not population-based (Hopkins and Morley, 1991;Nakanishi et al, 2000), or did not make direct comparisons between patients with squamous cell carcinoma and adenocarcinoma (Benedet et al, 1998). Some studies attributed the decreased survival of women with adenocarcinoma to differences in histological type (Lai et al, 1999;Grisaru et al, 2001).…”

Section: Incidence and Survival Of Cervical Cancer S Bulk Et Almentioning

confidence: 99%

“…Moreover, patients with adenocarcinomas of the cervix are considered to have a decreased survival compared to patients with squamous cell carcinomas (Hopkins and Morley, 1991;Lai et al, 1999;Nakanishi et al, 2000;Grisaru et al, 2001). It has been suggested that this decreased survival is associated with higher stages of disease with which patients with adenocarcinomas are detected.…”

mentioning

confidence: 99%

Incidence and survival rate of women with cervical cancer in the Greater Amsterdam area

et al. 2003

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To evaluate the effect of population-based cervical cancer screening on the occurrence of cervical cancer in The Netherlands, we investigated the incidence and survival of cervical cancer registered by a cancer registry in the Greater Amsterdam area. The incidence rate of squamous cell carcinoma decreased significantly from 9.2/100 000 women in 1988 to 5.9/100 000 in 2000 (Po0.001). The incidence rate of adenocarcinomas remained stable. After adjustment for age, stage and lymph node involvement, the relative risk of death was 1.6 times higher for patients with adenocarcinomas than for patients with squamous cell carcinoma (95% CI 1.2 -2.1). The decreased survival was related to histological type, as the effect remained significant after correction for confounding factors. Over time, the prognosis of women with squamous cell carcinoma improved significantly. No significant change was observed for women diagnosed with adenocarcinoma. These results suggest that the screening programme in The Netherlands as executed in the Greater Amsterdam area is associated with a decreased incidence and increased survival of patients with squamous cell carcinoma, but fails to detect (pre)malignant lesions of adenocarcinoma. Since more than 92% of adenocarcinomas and its precursors contain high-risk HPV, adding HPV testing to cytologic screening might improve the present screening programme in detecting adenocarcinoma and its precursor lesions.

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Does histology influence prognosis in patients with early-stage cervical carcinoma?

Grisaru

Covens

Chapman

et al. 2001

Cancer

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A Comparison of Prognoses of Pathologic Stage Ib Adenocarcinoma and Squamous Cell Carcinoma of the Uterine Cervix

Cited by 127 publications

References 17 publications

Prognostic Impact of Histology in Patients with Cervical Squamous Cell Carcinoma, Adenocarcinoma and Small Cell Neuroendocrine Carcinoma

Prognostic Impact of Histology in Patients with Cervical Squamous Cell Carcinoma, Adenocarcinoma and Small Cell Neuroendocrine Carcinoma

Incidence and survival rate of women with cervical cancer in the Greater Amsterdam area

Does histology influence prognosis in patients with early-stage cervical carcinoma?

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