A comparison of propafenone and amiodarone in reversion of recent-onset atrial fibrillation to sinus rhythm

Negrini, M.; Gibelli, G; Ponti, C. De

doi:10.1016/s0011-393x(05)80319-4

Cited by 12 publications

(6 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been shown in other studies that the efficacy of amiodarone in the termination of AF of different duration is significantly lower than that of class Ic drugs when assessed within the first 3 h of treatment. 6,11,14 In our study, the difference between efficacy of amiodarone and control treatment started to be significant after 8 h of treatment, when 50% of patients receiving amiodarone were converted to sinus rhythm. This is not surprising because intravenous amiodarone exerts different electrophysiologic effects than oral formulation.…”

Section: Conversion Ratementioning

confidence: 46%

“…[11][12][13][14] These discrepancies, perhaps, may occur by chance, as the study groups were small. The differences in patients' baseline characteristics, duration of index AF episode, and mode of 332 Table I.…”

Section: Conversion Ratementioning

confidence: 99%

“…The results of these studies are discordant: the efficacy rate varies from only 59% to as much as 92%. The remaining published studies [11][12][13][14][15][16] dealt either with patients with longer AF duration or oral loading of amiodarone.…”

Section: Conversion Ratementioning

confidence: 99%

See 2 more Smart Citations

Intravenous amiodarone for cardioversion of recent‐onset atrial fibrillation

Cybulski

Kułakowski

Budaj

et al. 2003

Clinical Cardiology

View full text Add to dashboard Cite

SummaryBackground: Atrial fibrillation (AF) is one of the most common causes of hospital admission, with a prevalence of up to 5% of the population, increasing with advancing age. Emergency direct current cardioversion is the therapy of choice when arrhythmia leads to hemodynamic compromise, but in patients who are hemodynamically stable, antiarrhythmic drugs are usually given to restore sinus rhythm.Hypothesis: The study was undertaken to assess the efficacy of intravenous amiodarone in cardioversion of recent-onset paroxysmal atrial fibrillation (AF). No standard antiarrhythmic therapy has been accepted for pharmacologic cardioversion of AF. Amiodarone seems to be a promising candidate, but only few randomized trials are available and the results are inconsistent.Methods: In all, 160 patients with AF lasting < 24 h were randomly assigned (2:1 fashion) to the amiodarone group (n = 106) receiving 5 mg/kg as a 30 min intravenous (IV) infusion, followed by IV infusion of 10 mg/kg during 20 h diluted in 1000 ml of 10% glucose with 20 IU of rapid-action insulin, 80 mEq of potassium chloride, and 8 g of magnesium sulphate (GIKM), or to the control group (n = 54) receiving 1000 ml of

show abstract

Section: Conversion Ratementioning

confidence: 46%

Section: Conversion Ratementioning

confidence: 99%

See 1 more Smart Citation

Intravenous amiodarone for cardioversion of recent‐onset atrial fibrillation

Cybulski

Kułakowski

Budaj

et al. 2003

Clinical Cardiology

View full text Add to dashboard Cite

show abstract

“…Propafenone Versus Other Drugs. The effectiveness of propafenone for the treatment of recentonset AF has been compared with that of flecainide (64,73,95), amiodarone (68,76,82), quinidine (95), digoxin (80,90,96), and verapamil (73,81).…”

Section: Intravenousmentioning

confidence: 99%

“…Intravenous amiodarone (68,76,82) and the combination of quinidine with digoxin (95) have been shown to be slower-acting and less effective, or equally effective (76), than propafenone in this setting. A recent placebo-controlled, crossover comparison between propafenone and digoxin given intravenously to patients with AF of less than 72 hours, showed, as expected, higher conversion rates after propafenone treatment (90).…”

Section: Intravenousmentioning

confidence: 99%