A comparison of protective effects between l-histidine and hypothermia against ischemia-induced neuronal damage in gerbil hippocampus

Adachi, Naoto; Liu, Keyue; Motoki, Atsuko; Hiraga, Norihito; Irisawa, Yumi; Semba, Kazunori; Arai, T.

doi:10.1016/j.ejphar.2006.07.023

Cited by 7 publications

(11 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies of combined L-histidine and thioperamide have found that the neuroprotective effects of L-histidine and thioperamide in ischemic injury are associated with anti-apoptotic processes (Adachi et al, 2006;Motoki et al, 2005). Although apoptosis was present in the brain after surgical brain injury Figure 3), apoptosis appears to play a relatively small role in cell death in this model.…”

Section: Discussionmentioning

confidence: 84%

“…Many of the previous experimental studies of Lhistidine and thioperamide therapy have described neuroprotection in the setting of ischemic brain injury. For example, the combined L-histidine and thioperamide treatment strategy has been used successfully in previous studies of focal ischemia (Motoki et al, 2005) and global ischemia (Adachi et al, 2006) in rodents. Although ischemic injury is present after surgical brain injury, the ischemic component may play a relatively small role in the pathophysiology of the injury Jadhav et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

“…Typical dosing regimens describe combined administration of L-histidine (1000 mg / kg) and thioperamide (5 mg / kg) (Motoki et al, 2005). Previous work has shown that combined L-histidine and thioperamide therapy is neuroprotective in global and focal ischemia (Adachi et al, 2006;Motoki et al, 2005). The neuroprotective mechanisms of L-histidine and thioperamide have only been partially explored to date, although an anti-apoptotic mechanism in the setting of ischemia is likely (Adachi et al, 2006;Motoki et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

“…L-histidine crosses the BBB where it is converted to histamine, and parenteral administration of L-histidine leads directly to elevated brain concentration of histamine (Motoki et al, 2005;Prell et al, 1996). L-histidine is neuroprotective in global ischemia (Adachi et al, 2006), focal cerebral ischemia (Adachi et al, 2004), and in vitro (Tang et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

“…Several studies have examined the therapeutic potential of combined L-histidine and thioperamide treatment in ischemic brain pathology (Adachi et al, 2006;Motoki et al, 2005). Thioperamide is a histamine H3 receptor antagonist.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Role of histamine in brain protection in surgical brain injury in mice

et al. 2008

View full text Add to dashboard Cite

Surgical resection of brain tissue is associated with tissue damage at the resection margin. Studies of ischemic brain injury in rodents have shown that administration of L-histidine and thioperamide reduces ischemic tissue loss, in part by inhibition of apoptotic cell death. In this study we tested administration of L-histidine and thioperamide in surgical brain injury in mice. Mice were randomized to one of three groups: Sham surgery (n=18), surgical brain injury without treatment (SBI) (n=33), and surgical brain injury with combined L-histidine and thioperamide treatment (SBI + H) (n=29). Surgical brain injury was induced via right frontal craniotomy with resection of the right frontal lobe. L-histidine (1000 mg / kg) and thioperamide (5 mg / kg) were administered to the SBI + H group immediately following surgical resection. Postoperative assessment included neurobehavioral scores, Evans blue measurement of blood-brain barrier breakdown, brain water content, Nissl histology, and immunohistochemistry for IgG and cleaved caspase 3. Postoperative findings included equivalent neurobehavioral outcomes at 24 and 72 hours in the SBI and SBI + H groups, similar histological outcomes between SBI and SBI + H, and similar qualitative staining for cleaved caspase 3. SBI + H had increased BBB breakdown on Evans blue analysis and a trend towards increased brain edema which was significant at 72 hours. We conclude that combined treatment with L-histidine and thioperamide leads to increased BBB breakdown and brain edema in surgical brain injury.

show abstract

Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Role of histamine in brain protection in surgical brain injury in mice

et al. 2008

View full text Add to dashboard Cite

show abstract

Suppression of inflammatory cell recruitment by histamine receptor stimulation in ischemic rat brains

Hiraga

Adachi

Liu

et al. 2007

European Journal of Pharmacology

View full text Add to dashboard Cite

Temperature control can abolish anesthesia‐induced tau hyperphosphorylation and partly reverse anesthesia‐induced cognitive impairment in old mice

Xiao

Run

Cao³

et al. 2013

Psychiatry Clin Neurosci

View full text Add to dashboard Cite

Aims: Anesthesia is related to cognitive impairment and the risk for Alzheimer's disease. Hypothermia during anesthesia can lead to abnormal hyperphosphorylation of tau, which has been speculated to be involved in anesthesia-induced cognitive impairment. The aim of this study was to investigate whether maintenance of the tau phosphorylation level by body temperature control during anesthesia could reverse the cognitive dysfunction in C57BL/6 mice.Methods: Eighteen-month-old mice were repeatedly anesthetized during a 2-week period with or without maintenance of body temperature, control mice were treated with normal saline instead of anesthetics. Tau phosphorylation level in mice brain was detected on western blot, and cognitive performance was measured using the Morris water maze (MWM).Results: After anesthesia-induced hypothermia in old mice, tau was hyperphosphorylated and the cognitive performance, measured on MWM, was impaired. When body temperature was controlled during anesthesia, however, the tau hyperphosphorylation was completely avoided, and there was partial recovery in cognitive impairment measured on the MWM. Conclusion:Hyperphosphorylation of tau in the brain after anesthesia is an important event, and it might be, although not solely, responsible for postoperative cognitive decline.

show abstract

A comparison of protective effects between l-histidine and hypothermia against ischemia-induced neuronal damage in gerbil hippocampus

Cited by 7 publications

References 33 publications

Role of histamine in brain protection in surgical brain injury in mice

Role of histamine in brain protection in surgical brain injury in mice

Suppression of inflammatory cell recruitment by histamine receptor stimulation in ischemic rat brains

Temperature control can abolish anesthesia‐induced tau hyperphosphorylation and partly reverse anesthesia‐induced cognitive impairment in old mice

Contact Info

Product

Resources

About