A Comparison of Proteinoid and Aldocyanoin Microsystems as Models of the Primordial Protocell

Kenyon, Dean H.

doi:10.1007/978-1-4684-4640-1_13

Cited by 3 publications

(3 citation statements)

References 49 publications

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“…Exposing thermal proteinoid polymers directly to chloroform at a concentration of 25mg/L caused significant but controlled changes in the patterns of emerging excitation waves (Fig. [9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28]. Average spike amplitude detected 0.065±0.009 mV -demonstrating 90% attenuation relative to baseline (Fig.…”

Section: Solvated Chloroform Response Dynamicsmentioning

confidence: 99%

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On effect of chloroform on electrical activity of proteinoids

Mougkogiannis,

Adamatzky

2023

Preprint

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Proteinoids, or thermal proteins, produce hollow microspheres in aqueous solution. Ensembles of the microspheres produce endogenous spikes of electrical activity, similar to that of neurons. To make a first step towards evaluation of the mechanisms of such electrical behaviour we decided to expose proteinoids to chloroform. We found that while chloroform does not inhibit the electrical oscillations of proteinoids it causes substantial changes in the patterns of electrical activity. Namely, incremental chloroform exposure strongly affect proteinoid microsphere electrical activity across multiple metrics. As chloroform levels rise, the spike potential drops from 0.9 mV under control conditions to 0.1~mV at 25 mg/mL. This progressive spike potential decrease suggests chloroform suppresses proteinoid electrical activity. The time between spikes, the interspike period, follows a similar pattern. Minimal chloroform exposure does not change the average interspike period, while higher exposures do. It drops from 23.2~min under control experiments to 3.8~min at 25 mg/mL chloroform, indicating increased frequency of the electrical activity. These findings might leads to deeper understanding of the electrical activity of proteinoids and their potential application in the domain of bioelectronics.

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Section: Solvated Chloroform Response Dynamicsmentioning

confidence: 99%

“…Proteinoids exhibit a specific susceptibility to chemical stimuli that cause alterations in their morphology [26, 27, 28]. Changes in both the structural and electrostatic binding affect the tertiary conformations and likely the properties of ion permeability [29, 30].…”

Section: Introductionmentioning

confidence: 99%

On effect of chloroform on electrical activity of proteinoids

Mougkogiannis,

Adamatzky

2023

Preprint

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“…Proteinoids exhibit a specific susceptibility to chemical stimuli that causes alterations in their morphology [26][27][28]. Changes in both the structural and electrostatic binding affect the tertiary conformations and likely the properties of ion permeability [29,30].…”

Section: Introductionmentioning

confidence: 99%

On Effect of Chloroform on Electrical Activity of Proteinoids

Mougkogiannis,

Adamatzky

2024

Biomimetics

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Proteinoids, or thermal proteins, produce hollow microspheres in aqueous solutions. Ensembles of the microspheres produce endogenous spikes of electrical activity, similar to that of neurons. To make the first step toward the evaluation of the mechanisms of such electrical behaviour, we decided to expose proteinoids to chloroform. We found that while chloroform does not inhibit the electrical oscillations of proteinoids, it causes substantial changes in the patterns of electrical activity. Namely, incremental chloroform exposure strongly affects proteinoid microsphere electrical activity across multiple metrics. As chloroform levels rise, the spike potential drops from 0.9 mV under control conditions to 0.1 mV at 25 mg/mL. This progressive spike potential decrease suggests chloroform suppresses proteinoid electrical activity. The time between spikes, the interspike period, follows a similar pattern. Minimal chloroform exposure does not change the average interspike period, while higher exposures do. It drops from 23.2 min under control experiments to 3.8 min at 25 mg/mL chloroform, indicating increased frequency of the electrical activity. These findings might lead to a deeper understanding of the electrical activity of proteinoids and their potential application in the domain of bioelectronics.

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The Emergence of Living Functions from Molecules

Fox

1990

Symmetries in Science IV

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A Comparison of Proteinoid and Aldocyanoin Microsystems as Models of the Primordial Protocell

Cited by 3 publications

References 49 publications

On effect of chloroform on electrical activity of proteinoids

On effect of chloroform on electrical activity of proteinoids

On Effect of Chloroform on Electrical Activity of Proteinoids

The Emergence of Living Functions from Molecules

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