A comparison of radiographic and bone scan findings in histiocytosis X

Abstract

In 17 patients with histologically proven histiocytosis X radiographs and bone scans were compared. The radiographic skeletal survey is superior to bone scanning for the primary detection of bony lesions. In contrast, skeletal scans are more reliable in follow-up examinations and for the detection of recurrences.

Clinico-biologic profile of Langerhans cell histiocytosis: A single institutional study

“…[10,12,13] Radionuclide scanning provided no additional benefit as against its suggested complementary role in recent studies. [14][15][16][17] Dermal involvement (25%) was less common in contrast to 35-50% cases in most series. [12,17] This is likely to be due to underdiagnosis of minor lesions such as seborrheic dermatitis.…”

Radiographic skeletal survey and radionuclide bone scan in Langerhans cell histiocytosis of bone

“…Patients with isolated bone lesions generally have an excellent prognosis, and spontaneous healing usually occurs. Furthermore, local treatment of areas susceptible to fracture may be required [9,12,13], and these areas must be identified. They stress the self-limiting character of the disease and plead for a moderate approach to treatment [1,[6][7][8][9][10].…”

“…They stress the self-limiting character of the disease and plead for a moderate approach to treatment [1,[6][7][8][9][10]. The use of RBS for detecting LCH bone lesions in childhood has been disputed ever since it was first reported [11,13,[15][16][17][18][19][20][21][22]. It is thus mandatory to assess the osseous extent of the disease in the initial work-up to guarantee a correct therapeutic decision and appropriate follow-up [11].…”

“…In our institution, the presence of more than three progressive LCH bone lesions is generally considered as a requirement for chemotherapy. The reported sensitivity of RBS varies between 35 % and 94 % [11,13,[15][16][17][18][19][20][21][22], reaching 100 % in cases of a single bone lesion in two studies [20,22]. Furthermore, local treatment of areas susceptible to fracture may be required [9,12,13], and these areas must be identified.…”

Paediatric nuclear medicine

“…Skeletal scintigraphy is recommended in cases of benign bone tumours, especially if the following problems are in question: diagnosis of osteoid osteoma (Smith et al 1980;Omojola et al 1981;); evidence of growth activity of cartilaginous exostosis (Sneppen et al 1978;Hudson et al /983;Lange et al 1984); expansive bone lesions on radiography to differentiate between aneurysmal bone cysts and a malignant change (Buirsky et al 1984;Hudson 1984); determination of the activity and expansion in fibrous dysplasia (Fitzer 1977;Doppelfeld etal. 1980;Crone-Mfinzebrock and Brassow 1983;Schaub et al/983, 1987). 1980;Crone-Mfinzebrock and Brassow 1983;Schaub et al/983, 1987).…”