A comparison of ranitidine, droperidol or placebo in the prevention of nausea and vomiting after hysterectomy

Cozanitis, D. A.; Asantila, R.; Eklund, P.; Paloheimo, Markku

doi:10.1007/bf03011249

Cited by 9 publications

(4 citation statements)

References 11 publications

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“…Although speculative, we hypothesized that these drugs are included in the suicide kit to reduce emesis and therefore to increase ingestion and tolerance to sodium nitrite. 27,28 In conclusion, based on the results of the forensic, toxicological, and death scene investigation, the cause of death was due asphyxia resulting from methemoglobinemia induced by sodium nitrite overdose. Although, poor health condition or pre-existing disease, such as anemia, acidosis, respiratory compromise, and cardiac disease, increases the susceptibility to the fatal consequences of nitrite poisoning, 9 autopsy did not reveal any remarkable signs of previous disease.…”

Section: Discussionmentioning

confidence: 98%

A fatal case by a suicide kit containing sodium nitrite ordered on the internet

Durão

Pedrosa

Dinis-Oliveira

2020

Journal of Forensic and Legal Medicine

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Fatal sodium nitrite poisonings are rare in the forensic context. The present work describes a first fatal case of sodium nitrite contained in a suicide kit that the victim acquired over the internet. The results of the autopsy showed general signs of asphyxia, such as intense cyanosis of the extremities, brown-gray-blue-red livor mortis, and some Tardieu petechiae in addition to intense visceral congestion. It is clear that forensic experts must be aware of the proliferation of this market and the risks of improper selling of these substances through suicide support networks available on the internet. The lack of knowledge of this reality may become unidentifiable, when toxicological analysis contemplates only the most classical and frequent substances involved in poisoning and reinforce the importance of a careful analysis of the death scene.

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Section: Discussionmentioning

confidence: 98%

A fatal case by a suicide kit containing sodium nitrite ordered on the internet

Durão

Pedrosa

Dinis-Oliveira

2020

Journal of Forensic and Legal Medicine

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“…Six trials (295 patients received droperidol 0.25-0.75 mg) reported on a composite nausea and vomiting endpoint only. [11][12][13]17,18,22 These data were not analysed further.…”

Section: Antiemetic Efficacymentioning

confidence: 99%

“…Significantly fewer patients treated with droperidol were reported to have a headache postoperatively; the NNT point estimate was 24 ( Table 3, Supplemental Digital Content 5, http://links.lww.com/EJA/A26). 1,6,[13][14][15]17,21,22,[24][25][26]30 Significantly more patients receiving droperidol were restless; the number needed to harm was nine ( Table 3, Supplemental Digital Content 6, http:// links.lww.com/EJA/A26). For both outcomes, there was no evidence of dose-responsiveness.…”

Section: Further Beneficial and Harmful Effectsmentioning

confidence: 99%

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Low-dose droperidol (≤1 mg or ≤15 μg kg−1) for the prevention of postoperative nausea and vomiting in adults

Schaub

Lysakowski

Elia

et al. 2012

European Journal of Anaesthesiology

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Drugs for preventing postoperative nausea and vomiting

Carlisle

Stevenson²

2006

Cochrane Database of Systematic Reviews

227

133

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Either nausea or vomiting is reported to affect, at most, 80 out of 100 people after surgery. If all 100 of these people are given one of the listed drugs, about 28 would benefit and 72 would not. Nausea and vomiting are usually less common and, therefore, drugs are less useful. For 100 people, of whom 30 would vomit or feel sick after surgery if given placebo, 10 people would benefit from a drug and 90 would not. Between one to five patients out of every 100 people may experience a mild side effect, such as sedation or headache, when given an antiemetic drug. Collaborative research should focus on determining whether antiemetic drugs cause more severe, probably rare, side effects. Further comparison of the antiemetic effect of one drug versus another is not a research priority.

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A comparison of ranitidine, droperidol or placebo in the prevention of nausea and vomiting after hysterectomy

Abstract: Pirkko Eklund MD, Markku Paloheimo MO PHDPurpose: The effect of ranitidine on postoperative nausea and vomiting (PONV) Although 5-HT 3 receptor antagonist drugs such as ondansetron may. be effective anti-emetics after anaes-CAN J ANAESTH 1996/43:2 Ippl06-9

Cited by 9 publications

References 11 publications

A fatal case by a suicide kit containing sodium nitrite ordered on the internet

A fatal case by a suicide kit containing sodium nitrite ordered on the internet

Low-dose droperidol (≤1 mg or ≤15 μg kg−1) for the prevention of postoperative nausea and vomiting in adults

Drugs for preventing postoperative nausea and vomiting

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