A Comparison of Recombinant Urokinase with Vascular Surgery as Initial Treatment for Acute Arterial Occlusion of the Legs

Ouriel, Kenneth; Veith, Frank J.; Sasahara, Arthur A.

doi:10.1056/nejm199804163381603

Cited by 650 publications

(451 citation statements)

References 11 publications

Supporting

Mentioning

387

Contrasting

Unclassified

Order By: Relevance

“…The TOPAS trial was designed to evaluate patients with ALLI [13]. It recruited 544 patients randomly assigned to the surgery and thrombolysis arms of the study.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Treatment of acute lower limb ischaemia

Łukasiewicz

2016

Vasa

View full text Add to dashboard Cite

Summary: Acute lower limb ischaemia poses a major threat to limb survival. For many years surgical thromboembolectomy was the mainstay of treatment. Recent years have brought an endovascular revolution in the management of acute lower limb ischaemia. A wide range of endovascular procedures can nowadays be employed, providing results at least as good as the traditional surgical approach. This paper is an overview of currently utilised endovascular options as well as recent modifi cations of standard surgical techniques.

show abstract

“…The TOPAS trial was designed to evaluate patients with ALLI [13]. It recruited 544 patients randomly assigned to the surgery and thrombolysis arms of the study.…”

Section: Resultsmentioning

confidence: 99%

“…In large RCTs performed in the 1990s, mortality in surgical cohorts exceeded 5 %, major morbidity aff ected more than 25 % of patients and amputation rate reached 25 % after 6 months [13,14]. No signifi cant improvement has been observed in recent years [15 -18].…”

Section: Hybrid Treatmentmentioning

confidence: 99%

Treatment of acute lower limb ischaemia

Łukasiewicz

2016

Vasa

View full text Add to dashboard Cite

show abstract

“…The introduction of catheter-directed locally-administered thrombolytic agents has challenged three decades of dominance of the Fogarty catheter thrombectomy. Thrombolysis with such agents as urokinase, rt-PA, streptokinase, and reteplase has been investigated in uncontrolled trials as a therapeutic alternative to operation for http://www.mjms.mk/ http://www.id-press.eu/mjms/ acute peripheral arterial occlusion [7,[12][13][14][15][16][17].…”

Section: Discussionmentioning

confidence: 99%

Acute Iliac and Femoral Arterial Thrombosis Secondary to Total Hip Arthroplasty

Fatić

Zornić

Radojević

et al. 2014

Open Access Maced J Med Sci

View full text Add to dashboard Cite

In the presented case report, we evaluated the mechanism of the external iliac, the common femoral and the superficial femoral arterial thrombosis secondary to total hip arthroplasty. A 75-year-old female sufferd from 5.5 cm shorter left lower limb and same sade coxarthritis. Next day after arthroplasty and eqalisation of the lower limbs, an acute ishemia of the treated leg was presented. Multyscan CT angiography revealed the presence of the external iliac, the common femoral and the superficial femoral arterial thrombosis. From the best of our knowledge, it seems to be the only case of this arterial segment thrombosis after total hip arthroplasty and equalistaion of the lower limbs reported

show abstract

“…Se han podido detectar diferencias en el comportamiento de la placa ateromatosa en relación con la localización anatómica. Las placas de alto riesgo de las arterias de las extremidades inferiores son muy estenóticas y fibrosas (32). Dicha estenosis, asociada con un estado de hipercoagulabilidad, contribuye de manera decisiva al desarrollo de eventos agudos.…”

Section: Evolución Cronológicaunclassified

Efecto del alprostadil en los cultivos de músculo esquelético isquémico. Estudio proteómico comparativo frente a músculo sano

et al. 2014

View full text Add to dashboard Cite

El presente trabajo reúne las condiciones de rigor y originalidad científica para ser presentada como tesis doctoral.Y para que conste a los efectos oportunos firmo la presente certificación en El presente trabajo reúne las condiciones de rigor y originalidad científica para ser presentada como tesis doctoral.Y para que conste a los efectos oportunos firmo la presente certificación en ABREVIATURAS• ADP: Adenosín Difosfato• AC: Actina• ATP: Adenosín Trifosfato• Arg: arginina• BCA: ácido bicinconínico• Bcl-2 :B-cell Lymphoma 2• BSA: albúmina del suero bovino• CE: Célula embrionaria• CHAPS: cholamidopropil-2 hidroxi-1 propanosulfato• CML: Célula madre linfoide• Dl: decilitros• DGºf: Variación de la energía libre de Gibbs estándar de formación• DHAP: Dihidroxiacetona-fosfato• EAP: Enfermedad arterial periférica• EDTA: ácido etilendiaminotetraacético• ESI : del inglés, ElectroSpray Ionization• FAD: Flavín adenina dinucleótido• FADD : factor associated death domain• F-6-P: Fructosa 6 fosfato• FT-MS : del inglés, Fourier Transform ion cyclotron• G3P: Gliceraldehido 3 fosfato• G6P: Gliceraldehido 6 fosfato 20• HDL: Lipoproteina de alta densidad• HEPES: ácido 4-(2-HidroxiEtil)-1-PiperacinaEtanosulfónico.• ITB: Indice tobillo brazo• IPG: del inglés Isoelectric Phocusing Gradient• LDH: lactato deshidrogenasa• LDL: Lipoproteina de baja densidad• Lys: lisina• MALDI : del ingles, Matrix-Assisted Laser Desorption/Ionization• MDH: malato deshidrogenasa• Mcl-1 : Mieloid cell leucemia-1• mg: milígramos• Mi: Miosina• ml: mililitros• mm: milímetros• mmHg: milímetros de Mercurio• mmol: milimol• MS: espectrometría de masas• NAD: Nicotinamida adenina dinucleotido• nm: nanometros• PaO2: presión parcial arterial de oxígeno• PAS: Presión arterial sistólica• PC: piruvato carboxilasa• PCR: Proteina C reactiva• PEP: fosfoenolpirúvico• PGE1: Prostaglandina E1 21• PGE2: Prostaglandina E2• pg: picogramos• PVDF :del inglés polyvinylidene difluoride• SDS-PAGE :del inglés sodium dodecyl sulfate polyacrylamide gel electrophoresis• seg: segundos• SFB: suero fetal bovino• SNC: Sistema Nervioso Central• TNF: Factor de necrosis tumoral• TOF : del inglés, time of flight• TPI: Triosafosfato isomerasa• UAD: Unidades Arbitrarias Densitométricas• μg: nanogramos• 2-DE: del inglés 2-dimensional electrophoresis Cada haz está conformado por miles de fibras, perfectamente separables porque cada una está envuelta por su propia capa de tejido conjuntivo llamada endomisio. El total de fibras que finalmente tendrá el músculo queda establecido ya a los 4 ó 5 meses de vida fetal. El grosor, en cambio, es al nacer la quinta parte de lo que tendrá de adulto. En éste es muy variable, según el músculo de donde se saque la muestra ( a través de una biopsia). En general el grosor va de 10 milimicrones a 100 milimicrones (1 micrón es una parte de mil). Su longitud suele ir a lo largo de todo el recorrido del músculo, alcanzando hasta 30 centímetros en algunos casos.En el interior de cada fibra se encuentran las miofibrillas segmentadas en una estructura histológica conocid...

show abstract

A Comparison of Recombinant Urokinase with Vascular Surgery as Initial Treatment for Acute Arterial Occlusion of the Legs

Abstract: Despite its association with a higher frequency of hemorrhagic complications, intraarterial infusion of urokinase reduced the need for open surgical procedures, with no significantly increased risk of amputation or death.

Cited by 650 publications

References 11 publications

Treatment of acute lower limb ischaemia

Treatment of acute lower limb ischaemia

Acute Iliac and Femoral Arterial Thrombosis Secondary to Total Hip Arthroplasty

Efecto del alprostadil en los cultivos de músculo esquelético isquémico. Estudio proteómico comparativo frente a músculo sano

Contact Info

Product

Resources

About