A Comparison of Rheumatoid Arthritis Patients in Kuwait with Other Populations: Results from the KRRD Registry

Al‐Herz, Adeeba; Al-Awadhi, Adel; Saleh, Khulood; Al-Kandari, W.; Hasan, Eman; Ghanem, A.; Abutiban, Fatemah; Alenizi, Ahmad; Hussain, M.; Ali, Yousef; Khadrawy, Ahmad; Fazal, Ammad; Mokaddem, Khaled; Aftab, Beena; Haider, Najaf; Zaman, A.; Mazloum, Ghada; Bartella, Youssef; Hamed, Sally; Alsaber, Ahmad

doi:10.9734/bjmmr/2016/24673

Cited by 8 publications

(8 citation statements)

References 50 publications

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“…In this study, the finding that there was no association between RN and positivity for RF and ACPA was in contrast to a previous study [24] that reported such an association in spite of the similar prevalence of RF and ACPA in patients with RA in Kuwait compared to other populations [25] . This may raise questions regarding the previously proposed role of autoantibodies in the formation of RN in patients with RA.…”

Section: Discussioncontrasting

confidence: 99%

Low Prevalence of Nodules in Rheumatoid Arthritis Patients in Kuwait: A Description and a Comparison of Patients from the Kuwait Registry for Rheumatic Diseases

Al‐Herz

Al-Awadhi²,

Saleh³

et al. 2016

Med Princ Pract

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Objectives: To describe the prevalence of rheumatoid nodules (RN) in patients with rheumatoid arthritis (RA) and to compare their features with those of patients without RN. Subjects and Methods: Adult RA patients (n = 952) in the Kuwait Registry for Rheumatic Diseases from February 2013 to December 2015 were evaluated for RN. Demographic and serological features and disease activity and severity were obtained from the registry. Results: Of the 952 RA patients, 22 (2.3%) had RN and 930 (97.7%) did not. Age, sex, disease duration, smoking, and family history of an autoimmune rheumatic disease were similar. Obesity was more prevalent in the RN group, i.e. 11 (50%) vs. 326 (35.1%), p = 0.016. There was no difference in rheumatoid factor (RF) or anti-cyclic citrullinated peptide antibody positivity. Patients with RN had more sicca symptoms, i.e. 8 (36.4%) vs. 152 (16.3%), p = 0.025, a higher mean score on the visual analogue scale pain (3 ± 2.9 vs. 2 ± 2.7, p < 0.001), more tender joints (6.4 ± 8.8 vs. 4.2 ± 7.2, p = 0.001), a higher patient global assessment of disease activity (3.3 ± 2.7 vs. 2.3 ± 2.7, p < 0.001), and more deformities, i.e. 3 (13.6%) vs. 74 (8%), p = 0.034. The mean health assessment questionnaire score in RN patients was 1.1 versus 0.9 in patients without RN (p = 0.08). Patients with RN had a low disease activity (means: disease activity score [DAS-28], 3.02; clinical disease activity index, 7.7; and simple disease activity index, 10.4), similar to the other group. While the rates of methotrexate treatment were comparable, biologic therapy was administered more in patients with RN (i.e. 15 [68.2%] vs. 478 [51.4%], p < 0.001). Conclusion: In Kuwait, the prevalence of RN is low among RA patients. Patients with and without RN are similar in terms of demographics and serologic features, except for more obesity. However, patients with RN have more sicca symptoms, joint deformities, and painful and tender joints. Disease activity scores are low with more frequent biologic therapy.

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Section: Discussioncontrasting

confidence: 99%

Low Prevalence of Nodules in Rheumatoid Arthritis Patients in Kuwait: A Description and a Comparison of Patients from the Kuwait Registry for Rheumatic Diseases

Al‐Herz

Al-Awadhi²,

Saleh³

et al. 2016

Med Princ Pract

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“…The mean age (females: 49.6 ± 13.6 years; males: 50 ± 15.6 years) of the participants observed in the present study was very similar to what was reported in a Kuwaiti cohort (50.6 ± 12 years) [4]. However, a previous study from the UAE showed a younger age of the participants by approximately seven years (42.2 ± 14.3) [5].…”

Section: Discussionsupporting

confidence: 87%

“…Data on comorbidities in RA patients from Gulf countries is reported in the Kuwait cohort [4]. There was a significant difference in the prevalence of comorbidities among the 2 countries.…”

Section: Discussionmentioning

confidence: 99%

Demographic and Clinical Patterns of Rheumatoid Arthritis in an Emirati Cohort from United Arab Emirates

Namas

Joshi

Ali

et al. 2019

International Journal of Rheumatology

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This retrospective cohort study aimed to assess the demographic and clinical characteristics of rheumatoid arthritis (RA) in Emirati patients attending Cleveland Clinic Abu Dhabi, a large tertiary center in the Middle East. In this study, 414 Emirati patients with RA were evaluated over a 3-year period from April 2015 to April 2018. All patients fulfilled the 2010 RA ACR/EULAR criteria and were assessed for demographic and clinical characteristics. The estimated RA prevalence rate in our population cohort was 2.72%. Females showed predominance (80%) with a higher body mass index (31.4 ± 6.61, P = 0.0001) compared to males (28.8 ± 6.03, P = 0.0001). The most frequent comorbidity observed was dyslipidemia (43.5%) followed by hypertension (37.9%), diabetes mellitus (34.5%), and gastroesophageal reflux disease (33.1%). Xerophthalmia was the most frequent extra-articular manifestation. Rheumatoid factor and anti-citrullinated peptide were detected in 63.3% and 41.5% patients, respectively, while both were present in 33.3% of patients. Methotrexate, adalimumab, and rituximab were the most frequently prescribed disease modifying agents. In this study, we describe disease features that are unique to United Arab Emirates (UAE) patients and demonstrate that RA has a significant disease burden. Our findings highlight the need for a RA national registry to improve the quality of care of these patients in UAE.

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“…Multiple attempts have been made to establish RA patient registries in Saudi Arabia, the most recent being the Rheumatoid Arthritis Saudi Database (RASD), from which data are beginning to emerge [ 35 , 36 ]. Where available, registries such as the Kuwait Registry for Rheumatic Diseases [KRRD] and the Dubai Private Database, facilitate our understanding of patient characteristics, such as the mean age at diagnosis (49 years), prevalence of family history of rheumatic autoimmune disease (13%), the women:men ratio (3:1) [ 37 ], and main reasons for discontinuation of biologics (loss of efficacy and patient choice) [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

A Review of the Prevalence and Unmet Needs in the Management of Rheumatoid Arthritis in Africa and the Middle East

et al. 2020

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Estimates of the global prevalence of rheumatoid arthritis (RA) range from 0.24 to 1%, but vary considerably around the globe. A variation in RA prevalence is also expected across Africa and the Middle East, due to ethnic, climate, and socioeconomic differences. To assess the prevalence of RA in Africa and the Middle East, we searched Medline (via PubMed) and databases of major rheumatology conferences. Seventeen journal articles and 0 abstracts met the inclusion criteria. Estimated prevalence ranged from 0.06 to 3.4%. Most studies reported values near or below 0.25%. Consistent with data from other regions, RA was more prevalent among urban than rural populations, and among women than men. The women:men prevalence ratio ranged from 1.3:1 to 12.5:1, which suggests notable differences from the global average of 2:1. Relative increases in prevalence were observed in North Africa and the Middle East (13% since 1990) and Western Sub-Saharan Africa (14%), whereas rates in Eastern, Central, and Southern Sub-Saharan Africa show decreases (4-12%). Low disease awareness, delays to visit rheumatologists, and socioeconomic factors appear to hinder early diagnosis and aggressive treatment. Few countries have developed RA-specific treatment guidelines, and many physicians and patients face limited access to even basic treatments. An improved understanding of the epidemiology and management of RA, and the related socioeconomic consequences is necessary, so that targeted attempts can be made to encourage early diagnosis and treatment.

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A Comparison of Rheumatoid Arthritis Patients in Kuwait with Other Populations: Results from the KRRD Registry

Cited by 8 publications

References 50 publications

Low Prevalence of Nodules in Rheumatoid Arthritis Patients in Kuwait: A Description and a Comparison of Patients from the Kuwait Registry for Rheumatic Diseases

Low Prevalence of Nodules in Rheumatoid Arthritis Patients in Kuwait: A Description and a Comparison of Patients from the Kuwait Registry for Rheumatic Diseases

Demographic and Clinical Patterns of Rheumatoid Arthritis in an Emirati Cohort from United Arab Emirates

A Review of the Prevalence and Unmet Needs in the Management of Rheumatoid Arthritis in Africa and the Middle East

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