Neurological Research

2016

DOI: 10.1080/01616412.2016.1215032

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A comparison of risk factors and prognosis between intra and extracranial acute atherosclerotic stroke in the Turkish population: a prospective study

Sezgin Keheya¹,

²

,

³

et al.

Abstract: The prevalence of risk factors differs between ICAS and ECAS, and their influence differs for stroke severity and prognosis.

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Cited by 4 publications

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“…Also, a significant association relationship was found between the female gender and rate of change of the NIHSS, indicating that women showed significantly more descends in the NIHSS compared to men. This differs from studies in Turkey and North America where Keheya and colleagues and Williams and colleagues, respectively, found that the female gender was associated with less-favorable functional outcome among ischemic stroke patients due to more severe strokes and older age at stroke onset and that also females were at higher risk for ischemic strokes among patients with symptomatic intracranial atherosclerosis [24,[26][27][28][29].…”

Section: Discussioncontrasting

confidence: 69%

Predictors of the functional outcome after thrombolysis in an Egyptian patients’ sample

¹

,

²

,

³

et al. 2021

Egypt J Neurol Psychiatry Neurosurg

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Background About 6.2 million individuals worldwide and approximately 200 Egyptians/100,000 citizens have cerebrovascular stroke annually, and only less than 1% of stroke patients received intravenous (IV) thrombolysis in 2014. Outcome of the ischemic stroke after IV thrombolysis varies, and there is lack of data about the predicting factors that contributes to the outcome of ischemic strokes after IV thrombolysis in Egypt. Objective The aim of this work is to study the predictors of the functional outcome of ischemic cerebrovascular stroke after IV thrombolysis in Egyptian patients. Patients and methods This is a prospective study that includes acute ischemic stroke patients who received IV thrombolysis at the Alexandria University Hospital during the year from February 2017 to February 2018, and they were evaluated initially by Rapid Arterial Occlusion Evaluation (RACE) scale and followed-up serially for 6 months after thrombolysis using the National Institutes of Health Stroke Scale (NIHSS) and modified ranking score (mRS). Results Forty-five patients are included; 56% had favorable functional outcome (mRS 0–2) after 6 months, 68% had ≥ 4 points improvement in NIHSS after 6 months, and 13% had hemorrhagic conversion with 18% mortality rate. High initial RACE scale and long hospital stay are associated with poor functional outcome 6 months after thrombolysis. Conclusion Stroke severity demonstrated by high initial RACE and the duration of hospital stay are the two most significant predictors with an impact on the functional outcome of ischemic cerebrovascular stroke after thrombolysis.

“…Also, a significant association relationship was found between the female gender and rate of change of the NIHSS, indicating that women showed significantly more descends in the NIHSS compared to men. This differs from studies in Turkey and North America where Keheya and colleagues and Williams and colleagues, respectively, found that the female gender was associated with less-favorable functional outcome among ischemic stroke patients due to more severe strokes and older age at stroke onset and that also females were at higher risk for ischemic strokes among patients with symptomatic intracranial atherosclerosis [24,[26][27][28][29].…”

Section: Discussioncontrasting

confidence: 69%

Predictors of the functional outcome after thrombolysis in an Egyptian patients’ sample

¹

,

²

,

³

et al. 2021

Egypt J Neurol Psychiatry Neurosurg

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Background About 6.2 million individuals worldwide and approximately 200 Egyptians/100,000 citizens have cerebrovascular stroke annually, and only less than 1% of stroke patients received intravenous (IV) thrombolysis in 2014. Outcome of the ischemic stroke after IV thrombolysis varies, and there is lack of data about the predicting factors that contributes to the outcome of ischemic strokes after IV thrombolysis in Egypt. Objective The aim of this work is to study the predictors of the functional outcome of ischemic cerebrovascular stroke after IV thrombolysis in Egyptian patients. Patients and methods This is a prospective study that includes acute ischemic stroke patients who received IV thrombolysis at the Alexandria University Hospital during the year from February 2017 to February 2018, and they were evaluated initially by Rapid Arterial Occlusion Evaluation (RACE) scale and followed-up serially for 6 months after thrombolysis using the National Institutes of Health Stroke Scale (NIHSS) and modified ranking score (mRS). Results Forty-five patients are included; 56% had favorable functional outcome (mRS 0–2) after 6 months, 68% had ≥ 4 points improvement in NIHSS after 6 months, and 13% had hemorrhagic conversion with 18% mortality rate. High initial RACE scale and long hospital stay are associated with poor functional outcome 6 months after thrombolysis. Conclusion Stroke severity demonstrated by high initial RACE and the duration of hospital stay are the two most significant predictors with an impact on the functional outcome of ischemic cerebrovascular stroke after thrombolysis.

“…Previous studies have shown gender differences in outcomes among IS patients with ICAS. For example, a recent prospective study conducted at a single hospital in Turkey showed that female gender was associated with severity and poor outcomes among IS patients with ICAS [5]. However, nationwide or multicenter large studies on gender differences in outcomes among symptomatic patients with ICAS have rarely been reported.…”

Section: Disclosure Statementmentioning

confidence: 99%

Gender Differences and Stroke Outcomes

2017

Neuroepidemiology

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No abstract

“…In this study, non‐HDLC is indicated as an independent risk factor for asymptomatic EICAS, especially in patients with hypertension. Previous studies revealed hyperlipidemia favoring for ECAS compared with ICAS . In the APAC study series, a positive relationship between non‐HDLC and the prevalence of asymptomatic ICAS has already been found (OR 1.15, 95% CI 1.08–1.23) .…”

Section: Discussionmentioning

confidence: 84%

Association between non‐high‐density lipoprotein cholesterol levels and the prevalence of asymptomatic extracranial internal carotid artery stenosis in a Chinese community‐based study

Wu¹,

Wang²,

et al. 2019

Euro J of Neurology

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Background and purpose Extracranial internal carotid artery thromboembolism is one major cause of ischaemic stroke and the predictive value of non‐high‐density lipoprotein cholesterol (non‐HDLC) is superior to low‐density lipoprotein cholesterol (LDLC). This study aimed to assess the association between non‐HDLC levels and the prevalence of asymptomatic extracranial internal carotid artery stenosis (EICAS) as well as the predictive value of non‐HDLC over LDLC on EICAS presence. Methods The Asymptomatic Polyvascular Abnormalities Community study is a subset of the Kailuan study emphasizing asymptomatic polyvascular abnormalities in Chinese adults. A total of 5351 participants, aged ≥40, without history of cardiovascular disease were enrolled in this study. Carotid duplex ultrasonography was carried out for the detection of EICAS. Results Of the 5351 patients, 2.5% (131/5351) were diagnosed with EICAS (stenosis ≥50%). Univariate analysis showed that non‐HDLC is an independent indicator for asymptomatic EICAS [odds ratio (OR) 1.49, 95% confidence interval (CI) 1.17–1.91]; the same result was reached in multivariate analysis after adjustment for confounding factors (OR 1.32, 95% CI 1.00–1.75), especially for people with hypertension (OR 1.52, 95% CI 1.11–2.08), whilst non‐HDLC failed to show better predictive value of EICAS than LDLC (OR 1.45, 95% CI 1.02–2.05). Conclusions Non‐HDLC is an independent risk factor for EICAS prevalence, especially for hypertension patients. Although the predictive value of non‐HDLC was no better than LDLC on EICAS presence, non‐HDLC is still a powerful atherogenic factor and potential therapeutic target for EICAS.

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