1999
DOI: 10.1002/(sici)1099-1263(199907/08)19:4<261::aid-jat572>3.3.co;2-x
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A comparison of statistical approaches to the derivation of EC3 values from local lymph node assay dose responses

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Cited by 23 publications
(40 citation statements)
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“…In each case, a stimulation index (SI) relative to the concurrent vehicle-treated control value was derived. The estimated concentration of chemical required to induce an SI of 3 relative to concurrent vehicle-treated controls, or EC3 value, was derived by linear interpolation of doseresponse data, as described previously (4). The EC3 value was calculated by interpolating between 2 points on the SI axis, one immediately above, and the other immediately below, the SI value of 3.…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…In each case, a stimulation index (SI) relative to the concurrent vehicle-treated control value was derived. The estimated concentration of chemical required to induce an SI of 3 relative to concurrent vehicle-treated controls, or EC3 value, was derived by linear interpolation of doseresponse data, as described previously (4). The EC3 value was calculated by interpolating between 2 points on the SI axis, one immediately above, and the other immediately below, the SI value of 3.…”
Section: Methodsmentioning
confidence: 99%
“…The local lymph node assay (LLNA) is the only validated alternative to the historical guinea-pig predictive assays for the identification of potentially skin-sensitizing chemicals (1). However, an additional benefit accruing from the LLNA is its ability to provide quantitative measurements of the relative potency of contact allergens via estimation of the concentration of a chemical required to stimulate a threshold positive response, the EC3 value (2)(3)(4). EC3 values for a range of substances have been shown to correlate closely with what is understood concerning their allergic potency in man (5)(6)(7).…”
mentioning
confidence: 99%
“…Test materials that at 1 or more concentrations caused an SI greater than 3 were considered to be positive in the LLNA. EC3 values (the estimated concentration required to induce an SI of 3) were calculated by linear interpolation and used to compare the sensitizing capacity of the different test materials (13). The sensitizing potency of the test substances was classified according to the following: EC3 < 0.1%, extreme; EC3 !…”
Section: Sensitization Experiments In Micementioning
confidence: 99%
“…That this is the case has been fully demonstrated. [10][11][12][13][14] Perhaps the most important of the points is the demonstration that EC3 values derived from the LLNA correlate with what is understood about the relative potency of skin allergens in humans. Several publications have already indicated that this is indeed the case, [15][16][17] and the currently available data are summarized in Table 1.…”
Section: Llna: Risk Assessmentmentioning
confidence: 99%