A comparison of stress reactivity between BTBR and C57BL/6J mice: an impact of early-life stress

Ayriyants, Kseniya A.; Ryabushkina, Yulia; Sapronova, Anna A.; Ivanchikhina, Anna V.; Kolesnikova, Maria M.; Bondar, Natalia P.; Reshetnikov, Vasiliy V.

doi:10.1007/s00221-022-06541-1

Cited by 7 publications

(2 citation statements)

References 79 publications

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“…4 These differences in ELA effects on hyper - vs hypo reactivity to future stressors may depend on the timing, intensity, and duration of early adversities. 3,6,61,67 Moreover, ELA effects on CORT responses have been reported to differ between different strains of mice, 50 indicating a potential role for genotypic differences in moderating ELA effects on stress reactivity.…”

Section: Discussionmentioning

confidence: 99%

Resilience to Early Life Adversity Effects on Stress Reactivity by Postnatal Knockdown of 5-HT_1AAutoreceptors

Dixon,

Malave,

Thompson

et al. 2024

Preprint

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Early Life Adversity (ELA) predisposes to stress hypersensitivity in adulthood, but neurobiological mechanisms that can protect from long-lasting effects of ELA are poorly understood. Serotonin 1A (5HT1A) autoreceptors in the raphé nuclei regulate adult stress vulnerability, but if 5HT1Acould be targeted to prevent ELA effects on susceptibility to future stressors is unknown. Here, we exposed mice with postnatal knockdown of 5HT1Aautoreceptors to the limited bedding and nesting model of ELA from postnatal day (P)3-10. We then tested behavioral, neuroendocrine, neurogenic, and neuroinflammatory responses to an acute swim stress in male and female mice in adolescence (P35) and in adulthood (P56). In ELA-exposed females, adult swim stress exposure increased passive coping and despair-like behavior, corticosterone levels at baseline and after stress, and neuronal activity and corticotropin releasing hormone levels in the paraventricular nucleus of the hypothalamus. ELA also reduced neurogenesis and increased microglia activation in the ventral dentate gyrus (DG) of the hippocampus – an important mediator of individual differences in stress susceptibility. These effects of ELA were specific to females, but not males, and manifested predominantly in adulthood, but not earlier on in adolescence. Postnatal 5HT1Aautoreceptor knockdown prevented ELA effects on stress reactivity and on neurogenesis and neuroinflammation in the DG, indicating that reducing 5HT1Aautoreceptors confers resilience to ELA. Our findings demonstrate that ELA induces long-lasting and sex-specific impairments in stress reactivity and ventral DG function across development, and identify 5HT1Aautoreceptors as potential targets to prevent these persistent effects of ELA.

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Section: Discussionmentioning

confidence: 99%

Resilience to Early Life Adversity Effects on Stress Reactivity by Postnatal Knockdown of 5-HT_1AAutoreceptors

Dixon,

Malave,

Thompson

et al. 2024

Preprint

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“…Early life stresses such as maternal separation (MS) stress disrupts the development of the brain and causes neurobehavioral changes in the adulthood; (Ayriyants et al, 2023; Reshetnikov et al, 2021). It has been determined that MS trigger neuroinflammatory response in the brain and consequently leads to negative behavioral effects (Gracia‐Rubio et al, 2016; Lorigooini et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Maternal separation stress through triggering of the neuro‐immune response in the hippocampus induces autistic‐like behaviors in male mice

Reisi‐Vanani,

Lorigooini,

Bijad

et al. 2023

Intl J of Devlp Neuroscience

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Autism spectrum disorder (ASD) is the fastest‐growing neurodevelopmental disease throughout the world. Neuro‐immune responses from prenatal to adulthood stages of life induce developmental defects in synaptic signaling, neurotransmitter imbalance, and even structural changes in the brain. In this study, we aimed to focus on the possible role of neuroinflammatory response in the hippocampus in development of the autistic‐like behaviors following maternal separation (MS) stress in mice. To do this, mice neonates daily separated from their mothers from postnatal day (PND) 2 to PND 14 for 3 h. During PND45–60, behavioral tests related to autistic‐like behaviors including three‐chamber sociability, Morris water maze (MWM), shuttle box, resident‐intruder, and marble burying tests were performed. Then, hippocampi were dissected out, and the gene expression of inflammatory mediators including TNF‐α, IL‐1β, TLR4, HMGB1, and NLRP3 was assessed in the hippocampus using RT‐PCR. Results showed that MS mice exerted impaired sociability preference, repetitive behaviors, impaired passive avoidance, and spatial memories. The gene expression of inflammatory mediators significantly increased in the hippocampi of MS mice. We concluded that MS stress probably via activating of the HMGB1/TLR4 signaling cascade in the hippocampus induced autistic‐like behaviors in mice.

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Mechanisms of Adaptation of the Hypothalamic-Pituitary-Adrenal Axis in Male Mice in Chronic Social Defeat Stress

Sapronova,

Ryabushkina,

Kisaretova

et al. 2024

Neurosci Behav Physi

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A comparison of stress reactivity between BTBR and C57BL/6J mice: an impact of early-life stress

Cited by 7 publications

References 79 publications

Resilience to Early Life Adversity Effects on Stress Reactivity by Postnatal Knockdown of 5-HT_1AAutoreceptors

Resilience to Early Life Adversity Effects on Stress Reactivity by Postnatal Knockdown of 5-HT_1AAutoreceptors

Maternal separation stress through triggering of the neuro‐immune response in the hippocampus induces autistic‐like behaviors in male mice

Mechanisms of Adaptation of the Hypothalamic-Pituitary-Adrenal Axis in Male Mice in Chronic Social Defeat Stress

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A comparison of stress reactivity between BTBR and C57BL/6J mice: an impact of early-life stress

Cited by 7 publications

References 79 publications

Resilience to Early Life Adversity Effects on Stress Reactivity by Postnatal Knockdown of 5-HT1AAutoreceptors

Resilience to Early Life Adversity Effects on Stress Reactivity by Postnatal Knockdown of 5-HT1AAutoreceptors

Maternal separation stress through triggering of the neuro‐immune response in the hippocampus induces autistic‐like behaviors in male mice

Mechanisms of Adaptation of the Hypothalamic-Pituitary-Adrenal Axis in Male Mice in Chronic Social Defeat Stress

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Product

Resources

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Resilience to Early Life Adversity Effects on Stress Reactivity by Postnatal Knockdown of 5-HT_1AAutoreceptors

Resilience to Early Life Adversity Effects on Stress Reactivity by Postnatal Knockdown of 5-HT_1AAutoreceptors