2000
DOI: 10.1034/j.1398-9995.2000.00702.x
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A comparison of the anti‐inflammatory properties of intranasal corticosteroids and antihistamines in allergic rhinitis

Abstract: Allergic rhinitis manifests itself clinically due to the local release of mediators from activated cells within the nasal mucosa. Treatment strategies aim either to reduce the effects of these mediators on the sensory neural and vascular end organs, or to reduce the tissue accumulation of the activated cells that generate them. Corticosteroids intervene at a number of steps in the inflammatory pathway, and, by reducing the release of cytokines and chemokines, inhibit cell recruitment and activation. These effe… Show more

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Cited by 16 publications
(11 citation statements)
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“…Experimental studies clearly showed that administration of MMP inhibitor into mice reduces the migration of inflammatory cells through the endothelial and epithelial basement membrane [33]. This inhibitory action of MMP inhibitor on cell migration is also reported to be because of its suppressive effect on the expression of intercellular adhesion molecule 1 and vascular adhesion molecule‐1 [6], which are essential molecules for cell migration into inflammatory tissues and are reported to be over‐expressed in AR [21]. From these reports, the negative suppressive effect of FEX on TIMP‐1 and TIMP‐2 production may contribute, in part, to favourable modification of clinical symptoms, when FEX is administered into patients with AR.…”
Section: Discussionmentioning
confidence: 99%
“…Experimental studies clearly showed that administration of MMP inhibitor into mice reduces the migration of inflammatory cells through the endothelial and epithelial basement membrane [33]. This inhibitory action of MMP inhibitor on cell migration is also reported to be because of its suppressive effect on the expression of intercellular adhesion molecule 1 and vascular adhesion molecule‐1 [6], which are essential molecules for cell migration into inflammatory tissues and are reported to be over‐expressed in AR [21]. From these reports, the negative suppressive effect of FEX on TIMP‐1 and TIMP‐2 production may contribute, in part, to favourable modification of clinical symptoms, when FEX is administered into patients with AR.…”
Section: Discussionmentioning
confidence: 99%
“…A review by Howarth [3] observed that there was no evidence from ‘limited studies available’ to support superiority of combination therapy compared with topical corticosteroid alone.…”
Section: Introductionmentioning
confidence: 99%
“…Hence, treatment of long-term ongoing allergic inflammation with H 1 receptor antagonists can be regarded as an attractive approach, in view of their prospective long-term safety in the clinic. There have been several studies addressed to identification of novel anti-inflammatory properties for this class of drugs [17, 18]. Anti-allergic and anti-inflammatory effects of antihistamines observed in vitro are generally recognized at concentrations that are several hundred-fold higher than would be expected to occur in vivo [19, 20].…”
Section: Introductionmentioning
confidence: 99%