A Comparison of the Antifertility Effects of Alkylating Agents and Vinca Alkaloids in Male Rats

Cooke, Robin A.; Nikles, A.; Roeser, H. P.

doi:10.1111/j.1476-5381.1978.tb17282.x

Cited by 10 publications

(1 citation statement)

References 11 publications

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“…Isolation of cucurbitane triterpenoids from M. charantia were also reported by Harinantenaina et al 2005 [45]. Triterpene isolated from Eugenia jambolana flowers and cytotoxic alkaloids from vinca are reported to have anti-fertility potential in male rats [46,47]. Triterpene Lupeol acetate isolated from benzene extract of Alstonia scholaressis has showed antifertility effect on male rats by decreasing spermatogenesis [48].…”

Section: Papiya Et Al 2012mentioning

confidence: 67%

Antifertility Activity of Momordica Charantia Descourt Pulp and Seed Hydroalcoholic Extract

Jerald¹,

Pandey²,

Bigoniya³

et al. 2012

J App Pharm

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Momordica charantia Descourt (Cucurbetaceae) known as Karela is an extremely bitter vegetable, commonly found in India. M. charantia had reported anticancer, antidiabetic, antihypertensive, anti-inflammation and antioxidant properties. It is used as antifertility agent in folklore; however no studies have been done on its antifertility action. Anti-fertility potential of the M. charantia hydroalcoholic extracts of seed and pulp was explored on in vitro spermicidal, antiovulatory, in vivo estrogenic and anti-estrogenic activity along with uterus histopathology. Data were presented as M  SEM and analyzed with ANOVA followed by t-test. MCHS and MCHP are tested for its antifertility activity at doses of 200 mg/kg and 400 mg/kg, orally as it was found safe on acute dosing of 2000 mg/kg. Pulp extract at 1280 µg/ml concentration caused significant damage to the sperm membrane integrity as evidenced by the reduction in sperm viability and tail curling. Administration of pulp extract at 400 mg/kg dose caused significant (p < 0.001) increases in uterine weight in immature rats while co-administration with ethinylestradiol decreased the uterus weight and increased the height of luminal epithelium with stimulated glands. Pulp extract at 400 mg/kg dose also caused significant (p < 0.001) prolongation estrous cycle and diestrous phase. Among the two extracts tested at two different doses, the hydroalcoholic pulp extract of M. charantia at 400 mg/kg was found to exhibit antifertility activity may be due to rich presence of triterpenoidal glycosides, flavonoids and alkaloids.

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Section: Papiya Et Al 2012mentioning

confidence: 67%

Antifertility Activity of Momordica Charantia Descourt Pulp and Seed Hydroalcoholic Extract

Jerald¹,

Pandey²,

Bigoniya³

et al. 2012

J App Pharm

View full text Add to dashboard Cite

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Antimitotic Drugs (Cyclophosphamide and Vinblastine) in the Male Rat Deaths and Behavioral Abnormalities in the Offspring

Auroux¹,

Dulioust²,

Nawar

et al. 1986

Journal of Andrology

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The spermatogenesis and the offspring of male rats treated either with cyclophosphamide alone, or with both cyclophosphamide and vinblastine were investigated. The offspring were evaluated for the mean number of pups per litter, sex ratio, the frequency of apparent external malformations and, within the first 4 months of life, growth and mortality. When they reached adulthood and were between 12 and 16 weeks of age, the offspring were also examined for spontaneous activity and learning capacity. Treatment with cyclophosphamide or cyclophosphamide and vinblastine resulted in a decrease in the number of both primary spermatocytes and spermatids; the effect, however, lasted longer for the combined drug regimen. At birth, the animals sired by the treated males did not show any apparent malformations. However, compared with the control population the mortality rate of the offspring was significantly higher within the first 40 days of life; at adult age, the proportion of animals that failed in the learning ability test was significantly increased and those that did succeed showed impaired learning capacity. The difference, however, was significant only in the male offspring. Finally, the offspring's spontaneous activity was significantly decreased. No difference was found in mortality or behavior between the animals born of the cyclophosphamide or cyclophosphamide plus vinblastine-treated males. The behavioral disorders shown in the adult offspring confirm the existence of a long-term risk of paternal origin. This risk, essentially functional and independent of any morphologic pathology, should be taken into account in the context of environmental genotoxicity.

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Antimitotic Drugs in the Male Rat Behavioral Abnormalities in the Second Generation

Auroux

Dulioust

Nawar

et al. 1988

Journal of Andrology

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The second generation descended from rats treated either with cyclophosphamide alone or with both cyclophosphamide and vinblastine were investigated. As in the first generation, the offspring were evaluated for mean litter size, sex ratio, frequency of gross external malformations and, within the first 4 months of life, growth and mortality. When they reached adulthood, between 12 and 16 weeks of age, the offspring were also tested for spontaneous activity and learning capacity. At birth, the progeny of the treated grandfathers did not show malformations or any other obvious disorder. However, when compared with the control population, the experimental animals showed significantly decreased success rates in a learning task, whatever the learning performance of their parents. Furthermore, decreased spontaneous activity was observed in the male subjects from unsuccessful parents. The similarities between the anomalies found in the first and the second generations argue for the induction of mutations by antimitotic drugs. This hypothesis and the subtle differences between generations and between sexes are discussed.

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A Comparison of the Antifertility Effects of Alkylating Agents and Vinca Alkaloids in Male Rats

Cited by 10 publications

References 11 publications

Antifertility Activity of Momordica Charantia Descourt Pulp and Seed Hydroalcoholic Extract

Antifertility Activity of Momordica Charantia Descourt Pulp and Seed Hydroalcoholic Extract

Antimitotic Drugs (Cyclophosphamide and Vinblastine) in the Male Rat Deaths and Behavioral Abnormalities in the Offspring

Antimitotic Drugs in the Male Rat Behavioral Abnormalities in the Second Generation

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