2007
DOI: 10.1111/j.1538-7836.2007.02677.x
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A comparison of the associations between seven hemostatic or inflammatory variables and coronary heart disease

Abstract: Summary. Background: While meta-analyses of prospective studies have established that plasma levels of several hemostatic variables are associated with the risk of coronary heart disease (CHD), these have been suggested to be acute-phase reactant proteins. This study examines their associations with inflammatory markers [C-reactive protein (CRP) and interleukin-6 (IL-6)] and the effect of adjustment on their associations with CHD risk. Methods and results: In a nested case-control study, 247 CHD cases and 473 … Show more

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Cited by 62 publications
(48 citation statements)
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“…We found a significant association between the inflammatory and hemostasis parameters and severity of the disease, thus indicating a significant interaction between inflammation and hemostasis mechanisms in the pathogenesis of AMI in concordance with a study conducted by Woodward et al [20]. In two recent studies [20,21], Lowe et al [21] and Yuan et al [22] reported a similar positive correlation between CRP and D-dimer as observed by us in their study on patients with ischemic heart disease.…”
Section: Discussionsupporting
confidence: 79%
See 1 more Smart Citation
“…We found a significant association between the inflammatory and hemostasis parameters and severity of the disease, thus indicating a significant interaction between inflammation and hemostasis mechanisms in the pathogenesis of AMI in concordance with a study conducted by Woodward et al [20]. In two recent studies [20,21], Lowe et al [21] and Yuan et al [22] reported a similar positive correlation between CRP and D-dimer as observed by us in their study on patients with ischemic heart disease.…”
Section: Discussionsupporting
confidence: 79%
“…In two recent studies [20,21], Lowe et al [21] and Yuan et al [22] reported a similar positive correlation between CRP and D-dimer as observed by us in their study on patients with ischemic heart disease. The statistically significant correlation observed between the inflammatory markers namely CRP and TNF-a with the hemostasis marker-D dimer suggests a possible interplay between inflammation and thrombotic pathways in laying the foundation of the molecular perturbations which finally lead to the consequences inherent to atherosclerosis.…”
Section: Discussionsupporting
confidence: 70%
“…In addition, hsCRP values increase with age (98 ). hsCRP concentration is also associated with sociodemographic indicators measured across the lifetime (42 ) and with a wide range of "emerging" cardiovascular risk factors (e.g., fibrinogen, adiponectin, type 1 plasminogen activator inhibitor, triglycerides, and others) (51,99,100 ). In the third National Health and Nutrition Examination Survey (NHANES), a high hsCRP concentration could be attributed to one or Reviews more borderline or abnormal levels of a number of factors (smoking, total cholesterol concentration, HDL-C concentration, triglyceride concentration, BP, fasting glucose concentration, and body mass index) in up to 78% of men and 67% of women (101 ).…”
Section: Existing and Forthcoming Evidence From Population-based Obsementioning
confidence: 99%
“…There may be other reasons, however. CRP is associated not only with BP, HDL-C, age, and sex, but also with diabetes, smoking, left ventricular hypertrophy, and atrial fibrillation (42,51,70,(85)(86)(87)(88), all of which already contribute to the Framingham risk model. Thus, the incremental information provided in a CRP measurement above that provided by the panel of variables included in the Framingham risk equation may be limited.…”
Section: Discriminationmentioning
confidence: 99%
“…The proposition that thrombosis is "hemostasis in the wrong place", 8,9 implies that the major processes leading to thrombin generation during pathologic coagulation are similar to those involved in hemostasis, perhaps differing only in intensity or location. In line with this reasonable hypothesis, most anticoagulants target thrombin, or plasma proteases such as factor Xa that are required for thrombin generation.…”
mentioning
confidence: 99%