A comparison of the behavior of vitamin K1 and K2 monolayers at the air–water interface

The ability of sterols other than cholesterol (CHOL) to support membrane functions in membranes that normally contain CHOL as the primary, if not sole, sterol may be due, in part, to how well such sterols can mimic CHOL's behavior and physical properties in membranes. We compared the mixing properties of CHOL, 7-dehydrocholesterol (7DHC), and desmosterol (DES) in egg phosphatidylcholine-sterol monolayer films containing 10, 20, and 30 mol percent sterol, measuring pressure-area isotherms on a Langmuir-Blodgett trough with the aqueous, buffered subphase maintained at 37 degrees C. Under the conditions employed, the pressure-area isotherms for all three sterols were similar, with 7DHC exhibiting slightly larger molecular areas on the water surface at all compositions. These results are discussed in the context of the ability of sterols such as 7DHC and DES to substitute structurally and functionally for CHOL in biological membranes.

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2005

Dictionary of Nutraceuticals and Functional Foods

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A comparison of the behavior of vitamin K1 and K2 monolayers at the air–water interface

Cited by 3 publications

References 7 publications

New trends in encapsulation of liposoluble vitamins

New trends in encapsulation of liposoluble vitamins

Comparative behavior of sterols in phosphatidylcholine-sterol monolayer films

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