A comparison of the biocompatibility of three absorbable hemostatic agents in the rat middle ear

Liening, Douglas A.; Lundy, Larry; Silberberg, Boris; Finstuen, Kenn

doi:10.1016/s0194-5998(97)70294-8

Cited by 41 publications

(37 citation statements)

References 13 publications

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“…Several trials have suggested that Gelfoam are biocompatible [11] and, in addition, Gelfoam packing has been long used in surgery of chronic otitis media without any complications. Some human studies suggest that absorbable gelatin film may predispose toward the formation of granulation tissue [16,17], whereas others suggest the opposite [17,18]. The present study showed no difference of granulation tissue between Gelfoam packing and no packing.…”

Section: Discussioncontrasting

confidence: 54%

Comparison between Gelfoam packing and no packing after endoscopic sinus surgery in the same patients

Wee

Lee

Rhee

et al. 2011

Eur Arch Otorhinolaryngol

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After functional endoscopic sinus surgery (FESS), nasal packing may be necessary and a packing material which has benefits in both cost and efficacy would be required. This study aimed to determine the efficacy of Gelfoam packing on hemostasis and wound healing after FESS. Patients who underwent bilateral FESS due to chronic bilateral rhinosinusitis were enrolled. Randomly, one side was selected for Gelfoam packing and the other side for no packing. Subjective symptoms and objective findings such as synechia, granulation, pus discharge, edema, stenosis, and crust were evaluated. A total of 21 patients (17 men and 4 women; mean age 39.7 years ranging from 12 to 75 years) were included. There were no statistical significant differences between two groups regarding both subjective symptoms and objective findings during 4 months after surgery. Three patients had postoperative bleeding in the no packing side. Gelfoam packing may be recommendable in terms of efficacy and cost-benefit after FESS.

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Section: Discussioncontrasting

confidence: 54%

Comparison between Gelfoam packing and no packing after endoscopic sinus surgery in the same patients

Wee

Lee

Rhee

et al. 2011

Eur Arch Otorhinolaryngol

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“…Gelfoam® has a long history of use as a hemostatic agent [24]. Gelfoam® has also been tested in bone repair [25, 26].…”

Section: Discussionmentioning

confidence: 99%

Biomimetic nanofibrous gelatin/apatite composite scaffolds for bone tissue engineering

et al. 2009

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Mimicking certain features (e.g. nanoscale topography and biological cues) of natural extracellular matrix (ECM) is advantageous for the successful regeneration of damaged tissue. In this study, nanofibrous gelatin/apatite (NF-gelatin/apatite) composite scaffolds have been fabricated to mimic both the physical architecture and chemical composition of natural bone ECM. A thermally induced phase separation (TIPS) technique was developed to prepare nanofibrous gelatin (NF-gelatin) matrix. The NF-gelatin matrix mimicked natural collagen fibers and had an average fiber diameter of about 150 nm. By integrating the TIPS method with porogen leaching, three-dimensional NF-gelatin scaffolds with well-defined macropores were fabricated. In comparison to Gelfoam® (a commercial gelatin foam) with similar pore size and porosity, the NF-gelatin scaffolds exhibited a much higher surface area and mechanical strength. The surface area and compressive modulus of NF-gelatin scaffolds were more than 700 times and 10 times higher than that of Gelfoam®, respectively. The NF-gelatin scaffolds also showed excellent biocompatibility and mechanical stability. To further enhance pre-osteoblast cell differentiation as well as improving mechanical strength, bone-like apatite particles (< 2 μm) were incorporated onto the surface of NF-gelatin scaffolds via a simulated body fluid (SBF) incubation process. The NF-gelatin/apatite scaffolds showed significantly higher mechanical strength than NF-gelatin scaffolds 5 days after SBF treatment. Furthermore, the incorporated apatite in the NF-gelatin/apatite composite scaffold enhanced the ostgeogenic differentiation. The expression of BSP and OCN in the osteoblast-(NF-gelatin/apatite composite) constructs was about 5 times and 2 times higher than in the osteoblast-(NF-gelatin) constructs 4 week after cell culture. The biomimetic NF-gelatin/apatite scaffolds are, therefore, excellent for bone tissue engineering.

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“…Gelfoam, a highly porous, gelatin sponge derived from porcine skin, is a material potentially suitable as a delivery vehicle for MSCs in cartilage regeneration therapy. It has a long history of use as a hemostatic agent 30 and also has been tested in bone repair, 31 both alone 32 and in conjunction with cytokines. 33,34 Gelfoam also has been shown to be supportive of chondrogenic matrix production in vitro when seeded with bovine chondrocytes.…”

Section: Introductionmentioning

confidence: 99%

Gelatin-based resorbable sponge as a carrier matrix for human mesenchymal stem cells in cartilage regeneration therapy

Ponticiello

Schinagl

Kadiyala

et al. 2000

J. Biomed. Mater. Res.

314

189

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Adult mesenchymal stem cells (MSCs), found in the bone marrow, have the potential to differentiate into multiple connective tissue types, including cartilage. In this study, we examined the potential of a porous gelatin sponge, Gelfoam, for use as a delivery vehicle for MSCs in cartilage regeneration therapy. Adult human MSCs (hMSCs) were seeded throughout the gelatin sponge after a 2-h incubation period. When cultured for 21 days in vitro in a defined medium supplemented with 10 ng/mL of TGF-beta 3, hMSC/Gelfoam constructs produced a cartilage-like extracellular matrix containing sulfated glycosaminoglycans (s-GAGs) and type-II collagen, as evident upon histologic evaluation. Constructs loaded with a cell suspension of 12 x 10(6) cells/mL produced an extracellular matrix containing 21 microg of s-GAG/microg of DNA after 21 days of culture. This production was more efficient than constructs loaded at higher or lower cell densities, indicating that the initial seeding density influences the ability of cells to produce extracellular matrix. When implanted in an osteochondral defect in the rabbit femoral condyle, Gelfoam cylinders were observed to be very biocompatible, with no evidence of immune response or lymphocytic infiltration at the site. Based on these observations we conclude that Gelfoam resorbable gelatin sponge is a promising candidate as a carrier matrix for MSC-based cartilage regeneration therapies.

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A comparison of the biocompatibility of three absorbable hemostatic agents in the rat middle ear

Cited by 41 publications

References 13 publications

Comparison between Gelfoam packing and no packing after endoscopic sinus surgery in the same patients

Comparison between Gelfoam packing and no packing after endoscopic sinus surgery in the same patients

Biomimetic nanofibrous gelatin/apatite composite scaffolds for bone tissue engineering

Gelatin-based resorbable sponge as a carrier matrix for human mesenchymal stem cells in cartilage regeneration therapy

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