A comparison of the combined effect of cryotherapy and corticosteroid injections versus corticosteroids and cryotherapy alone on keloids: a controlled study

Abstract

Combined injection of intralesional steroids with cryotherapy appears to be superior to other current modalities.

The Efficacy of Triamcinolone Acetonide in Keloid Treatment: A Systematic Review and Meta-analysis

“…No data on reduction in scar size or overall scar improvement could be extracted from the studies of Layton et al (17), Sproat et al (18), and Kelemen et al (19). Finally, eight studies were included in this meta-analysis (11, 16, 20–25). The characteristics of these eight studies were shown in Table 1.…”

“…Since the studies of Yosipovitch et al (20) and Tan et al (11) were not RCT, they were judged as high risk for random sequence generation. Four studies (22–25) provided the method used to generate random sequence and were judged to be at low risk of random sequence generation.…”

“…Two studies (16, 21) did not report the method of generating random sequence and we judged them at unclear risk. Allocation concealment was not reported in all of the eight studies (11, 16, 20–25), and we judged all trials as unclear for allocation concealment. Two single-blinded trials (16, 24) were judged as high risk for blinding of participants and personnel.…”

“…Two single-blinded trials (16, 24) were judged as high risk for blinding of participants and personnel. Complete information on the blinding processes was not shown by the left six studies (11, 20–23, 25) and we judged them at unclear risk for performance bias. Two studies (16, 25) employed blinded observer to assess outcomes and were judged at low risk of detection bias.…”

“…Two studies (16, 25) employed blinded observer to assess outcomes and were judged at low risk of detection bias. The left six trials (11, 20–24) were judged as unclear risk due to no report on blinding of outcome assessment. Four trials (11, 16, 20, 24) were judged at high risk for incomplete outcome data because the numbers lost to follow up were high and no reasons were given for the losses.…”