A Comparison of the Direct Fick and the Grollman Methods for Determination of the Cardiac Output in Man

Werkö, Lars; Berseus, S; Lagerlof, H

doi:10.1172/jci102098

Cited by 31 publications

(5 citation statements)

References 19 publications

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“…The values obtained (8 to 14 seconds) agree well with those obtained by others using different techniques: Gladstone (10 seconds), 23 Werko and coworkers (10 to 15 seconds), 6 and Chapman et al (12 seconds). 7 In particular, the results obtained by detecting recirculation as an upward deviation in the expiratory limb of the N 2 0 continuous record confirm the observations of Gladstone 23 and of Cander and Forster, 24 who plotted the fraction of the test gas in alveolar samples against the times at which the alveolar samples were collected.…”

Section: Early Becirculation Of the Test Gas In The Lungssupporting

confidence: 89%

Determination of the Pulmonary Capillary Blood Flow in Man

Rigatto

Fishman

1961

Circulation Research

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A method is described for the measurement of the pulmonary capillary blood flow in human subjects with normal lungs. The method depends on the performance of a vital capacity maneuver using nitrous oxide as the test gas. It attempts to circumvent the deficiencies of previous respiratory methods by using an infrared analyzer for the continuous measurement of the concentration of N 2 O in expired air, by ensuring that the respiratory maneuver is completed before recirculation occurs, and by determining simultaneously the values involved in the formula used for the calculation of the flow. As a basis for the method, the pulmonary recirculation time and the rate of N 2 O absorption by the lungs were measured separately. The values for the pul monary capillary blood flow obtained by the N 2 O method correlate well with those obtained by the direct Fick method: in 12 subjects, the average value by the N 2 O method was 5.65 L./min. in comparison with 5.55 L./min. by the direct Pick method; the mean Percentile deviation between the values obtained by the two methods in each subject was 11 per cent. The results obtained by the N 2 O method were also shown to be reproducible : In 14 subjects, successive measurements on the same occasion showed a mean percentile deviation of 6 per cent.

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Section: Early Becirculation Of the Test Gas In The Lungssupporting

confidence: 89%

Determination of the Pulmonary Capillary Blood Flow in Man

Rigatto

Fishman

1961

Circulation Research

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“…The recirculation times in our experiments are in agreement with those reported in the literature for inert gases [8,10,12,28,30,34] and are longer than those found with the use of tracers that do not leave the vascular system. Sutton et al [33], with tagged erythrocytes found a recirculation time of 8.5 sec in man and Starr and Collins [32], with dye injection, reported that in dogs 21 % of the cardiac output had recirculated in 10 sec.…”

Section: Discussionsupporting

confidence: 91%

Determination of Pulmonary Blood Flow by Rebreathing of Soluble Inert Gases

et al. 1974

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The rate of disappearance of acetylene or nitrous oxide from the alveolar gas during rebreathing was studied in dogs and in man. The subjects, hyperventilating in steady state, were connected at end-expiration to a re breathing bag for 30 sec. After the initial 2-4 breaths the alveolar inert gas concentration followed a single exponential course until the beginning of recirculation. From the slope and intercept of this exponential at zero time the capillary blood flow and the tissue volume of the lung were calculated. Simultaneous determinations of the cardiac output were made with direct Fick method for oxygen in dogs and indirect Fick method in man. A good correlation was found between both methods. A theory is represented which takes into consideration the effect of ventilation limitation upon inert gas transfer within the rebreathing system

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“…The values obtained for CVN20 are comparable to those reported by other authors during pulmonary artery catheterization (Werko, Berseus & Lagerlof, 1949;Chapman et al 1950). The use of values of CVN2O obtained by our method in Fick's equation gives estimates of cardiac output during recirculation which are similar to those obtained before recirculation.…”

supporting

confidence: 89%

Proceedings of the Physiological Society, 20 May 1967, Cambridge Meeting: Demonstrations

1967

The Journal of Physiology

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A Comparison of the Direct Fick and the Grollman Methods for Determination of the Cardiac Output in Man

Cited by 31 publications

References 19 publications

Determination of the Pulmonary Capillary Blood Flow in Man

Determination of the Pulmonary Capillary Blood Flow in Man

Determination of Pulmonary Blood Flow by Rebreathing of Soluble Inert Gases

Proceedings of the Physiological Society, 20 May 1967, Cambridge Meeting: Demonstrations

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