A Comparison of the Effects of Thyrocalcitonin and Glucagon on Plasma Calcium and Phosphate

Tanzer, Francis S.; Kennedy, J. W.; Talmage, Roy V.

doi:10.3181/00379727-133-34506

Cited by 16 publications

(8 citation statements)

References 6 publications

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“…Following the original theory of calcium deposition with fatty acids, in and around the damaged pancreas, in the form of calcium soaps (Edmondson and Fields, 1942), various hypotheses have been invoked to explain the 'hypocalcaemia' of acute pancreatitis. These include the effect of hyperglucagonaemia per se (Paloyan et al, 1967;Tanzer et al, 1970;Cortes, 1971) or its effect in promoting calcitonin secretion (Pickleman et al, 1969;Shieber et al, 1969), hypomagnesaemia (Edmondson et al, 1952) and parathyroid gland insufficiency (Condon et al, 1975;Robertson et al, 1976). Neither the original theory nor any of these hypotheses provides a convincing explanation of the high incidence of hypocalcaemia in acute pancreatitis (Edmondson and Berne, 1944;Leading Article, 1975;Imrie et al, 1976).…”

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confidence: 99%

Serum ionized calcium in acute pancreatitis

Allam

Imrie

1977

Journal of British Surgery

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Measurement of serum ionized calcium was performed daily for 7 days after admission in 8 consecutive patients with acute pancreatitis. The results support the findings of our previous study that the most common cause of the low serum calcium often found in patients with this disease is a low serum albumin; when correction of serum calcium is made for hypo-albuminanemia, most patients are found to be normocalcaemic. The occasional hypocalcaemia as shown by the 'corrected' serum calcium or by serum ionized calcium measurement is usually mild and transient, indicating that the normal homoeostatic mechanisms of the body can efficiently maintain the physiologically active fraction of the serum calcium within, or close to, the normal range. These findings explain the rarity of overt and subclinical tetany in acute pancreatitis. This study has shown that correction of serum calcium for albumin provides similar information to the direct measurement of serum ionized calcium. The value of 'apparent' hypocalcemia in assessing severity of acute pancreatitis requires reappraisal, while greater attention should be directed towards the investigation and management of hypoalbuminaemia in this disease.

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confidence: 99%

Serum ionized calcium in acute pancreatitis

Allam

Imrie

1977

Journal of British Surgery

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“…Evidence to support this possibility was reported by Stern and Bell (1970), who showed that glucagon could inhibit parathyroid-hormone-stimulated bone resorption by a direct effect on the bone of intact and thyroparathyroidectomized rats. The experiments of Tanzer et al (1970), using radiophosphorus labels in rats, also support the concept of a direct action of glucagon on bone. Glucagon may, therefore, have a similar action to mithramycin in Paget's disease-namely, inhibiting resorption while still allowing the anabolic effect of parathyroid hormone on bone to continue (Condon et al, 1971).…”

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confidence: 52%

Glucagon in the Treatment of Paget's Disease of Bone

Condon¹

1971

BMJ

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“…The experiments of Tanzer et al (1970), using radiophosphorus labels in rats, also support the concept of a direct action of glucagon on bone. Glucagon may, therefore, have a similar action to mithramycin in Paget's disease-namely, inhibiting resorption while still allowing the anabolic effect of parathyroid hormone on bone to continue (Condon et al, 1971).…”

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confidence: 52%