A comparison of the effects of Ketamine-Midazolam and Ketamine-Propofol combinations on vital signs of uncooperative children with dental diseases in a crossover study with repeated measurements: The Bayesian approach

Abstract

Background: To calm non-cooperative children needing dental treatment, sedatives are used. Vital parameters must be monitored during sedation. This study aimed to evaluate the effects of Ketamine-Midazolam (KM) and Ketamine-Propofol (KP) combinations on the heart rate (HR) and oxygen saturation (SPO2) of uncooperative children. The model parameters were estimated using the Bayesian approach. Methods: The data were collected in a double-blind crossover study with repeated measurements (CSWRM). Twenty-two 3-6-year-old uncooperative children were included, and the linear mixed model was adopted for data analysis. Results: A significant difference of 4.47 beats per minute (bpm) was found in the mean HR of KM recipients compared to KP recipients. The mean HR in KP was lower than that of KM, but it did not make a difference in SPO2. Conclusions: Although there was no difference in the two drug combinations regarding SPO2, they differed in HR. As such, the KP combination is recommended. The study was registered in the Iranian Registry of Clinical Trials (IRCT20090506001882N10) at the date of 2021-03-08.