Abstract:The purpose of this study was to evaluate arterial blood gases in dogs that were given hydromorphone or extended release liposome-encapsulated hydromorphone (LEH). Dogs were randomly administered LEH, n = 6, (2.0 mg kg−1), hydromorphone, n = 6, (0.2 mg kg−1) or a placebo of blank liposomes, n = 3, subcutaneously on separate occasions. Arterial blood samples were drawn at serial time points over a 6-h time period for blood gas analysis. There was no change from baseline values in PaCO2, PaO2, (HCO3−), pH, and S… Show more
“…Mild respiratory depression may be observed, but in healthy animals is rarely of clinical significance. In one study, healthy dogs administered large doses of hydromorphone maintained PaCO 2 values between 43 and 48 mm Hg [27].…”
“…Mild respiratory depression may be observed, but in healthy animals is rarely of clinical significance. In one study, healthy dogs administered large doses of hydromorphone maintained PaCO 2 values between 43 and 48 mm Hg [27].…”
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