A comparison of the effects of buspirone and diazepam on plasma corticosterone levels in rat

Matheson, G.K.; Gage, Deanna; White, Gary W.; Dixon, Vanessa; Gipson, Debbie S.

doi:10.1016/0028-3908(88)90098-6

Cited by 45 publications

(13 citation statements)

References 37 publications

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“…These enhancements of the stress-induced elevations in circulating CORT concur with previous reports that circulating ACTH and CORT concentrations are elevated by acute administration of these drugs (Marc and Morselli, 1969;Matheson et al, 1988). Accordingly, the association between the emotional (anxiolytic vs anxiogenic) and hormonal effects of these drugs is not straightforward, and the HPA axis-activating properties do not specifically predict the emotional effects of these drugs after acute administration.…”

Section: Anxiogenic Action Of N/ofqsupporting

confidence: 87%

“…In fact, when we initially reported that N/OFQ increases circulating ACTH and CORT concentrations in unstressed and mildly stressed rats (Devine et al, 2001), we reconciled our hormonal findings with the published behavioral data (Jenck et al, 1997;Griebel et al, 1999) on the basis that a variety of drugs that are anxiolytic can also increase circulating CORT concentrations in unstressed or mildly stressed rats (Ellis, 1966;Kakihana et al, 1968;Marc and Morselli, 1969;Tabakoff et al, 1978;Rivier et al, 1984;Matheson et al, 1988Matheson et al, , 1997ade Boer et al, 1991). However, the current findings indicate that the behavioral and hormonal effects of N/OFQ resemble the effects of drugs like FG 7142 File, 1985, 1986), yohimbine (Smythe et al, 1983;Suemaru et al, 1989), amphetamine (Knych and Eisenberg, 1979;, and caffeine (Spindel et al, 1983;Fall of which are anxiogenic in neophobic tests of anxiety, and all of which elevate circulating ACTH and/or CORT concentrations after acute administration.…”

Section: Anxiogenic Action Of N/ofqsupporting

confidence: 53%

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Nociceptin/Orphanin FQ Increases Anxiety-Related Behavior and Circulating Levels of Corticosterone During Neophobic Tests of Anxiety

Fernandez

Misilmeri

Felger

et al. 2003

Neuropsychopharmacol

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Intracranial administration of nociceptin/orphanin FQ (N/OFQ) increases circulating concentrations of adrenocorticotrophic hormone and corticosterone in unstressed rats, and elevates the responsiveness of these hormones during mild stress. Furthermore, N/OFQ and its cognate receptor are both abundant in a variety of limbic nuclei, and stress exposure decreases neuronal N/OFQ content in forebrain neurons. In light of these and other findings, we examined the potential involvement of N/OFQ in regulation of anxiety-related behaviors in rats. In the open field, elevated plus maze, and dark-light neophobic tests, intracerebroventricular N/OFQ (1.0 pmole-1.0 nmole) increased the expression of anxiety-related behaviors. Specifically, N/OFQ increased the latency to enter, decreased the number of entries into, and decreased the time spent in the exposed or brightly lit environments of all three tests. N/OFQ also enhanced thigmotactic responses in the open field test. The effects of diazepam and of the benzodiazepine inverse agonist FG 7142 were also assessed in independent groups of rats. In all three tests, the behavioral effects of N/OFQ resembled the anxiogenic actions of FG 7142, and contrasted with the anxiolytic actions of diazepam. N/OFQ administration also increased circulating concentrations of corticosterone during anxiety testing, in comparison with the concentrations in vehicle-treated controls. We conclude that N/OFQ administration is anxiogenic, and elevates responsiveness of the hypothalamic pituitary-adrenal axis during neophobic tests of anxiety. This supports the possibility that N/OFQ neurotransmission participates in processing of emotionally-salient and stressful stimuli, and suggests that normal functioning of the N/OFQ system may be important in physiological and psychological well-being.

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Section: Anxiogenic Action Of N/ofqsupporting

confidence: 87%

Section: Anxiogenic Action Of N/ofqsupporting

confidence: 53%

Nociceptin/Orphanin FQ Increases Anxiety-Related Behavior and Circulating Levels of Corticosterone During Neophobic Tests of Anxiety

Fernandez

Misilmeri

Felger

et al. 2003

Neuropsychopharmacol

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“…The role of benzodiazepines on basal corticosteroid release is complex, and even though it has been extensively studied over the last three decades, there is still a lot of controversy in the literature. Benzodiazepines have, under basal conditions, been shown to stimulate [15][16][17], to inhibit [18,19], and to be ineffective [20] on CORT release.…”

Section: Introductionmentioning

confidence: 99%

Cannabinoids and Their Interactions with Diazepam on Modulation of Serum Corticosterone Concentration in Male Mice

et al. 2009

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Experimental results indicate a mutual interaction between cannabinoidergic and GABAergic systems; however, the interaction between these systems on corticosterone release has not been fully investigated. In this study, we treated male mice with either cannabinoid compounds alone or in combination with diazepam. Blood samples were collected at 60 min post-injection. The serum corticosterone (CORT) level was measured using ELISA technique. Acute treatment of mice by cannabinoid receptor agonist WIN55212-2 (2.5 mg/kg; i.p.) resulted in a significant reduction of CORT, while treatment with either endocannabinoid reuptake inhibitor AM404 or endocannabinoid degradation enzyme inhibitor URB597 increased CORT compared to control group. Co-administration of AM404 or URB597 with cannabinoid CB1 receptor antagonist AM251 blocked the effect of these compounds on CORT. Treatment of mice with different doses of diazepam alone did not alter CORT compared to control group. However, co-administration of diazepam and either AM404 or WIN55212-2 significantly reduced CORT compared to the respective group treated with cannabinoid compound alone. Co-administration of ineffective dose of URB597 and ineffective dose of diazepam increased CORT level compared to groups treated with each compound alone. In conclusion, our findings suggest that the endogenous cannabinoid system is active as a modulator of CORT in mice and diazepam can alter the effect of cannabinoid system in the modulation of neuroendocrine functions.

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“…Plasma was stored at -2 0°C until assayed. Duplicate plasma samples were analyzed by a sulfuric acid-induced fluo rescence method for corticosterone content from each blood sample [8], Circadian HPA effects were limited by restricting blood collection to the hours between 09.00 and 10.30 and between 15.00 and 16.30 h. Corticosterone levels measured between the beginning and the end of these periods were not significantly different. Each data point represents the mean plasma corticosterone level ±SEM collected from 8 animals.…”

Section: Experimental Designmentioning

confidence: 99%

Modification of Hypothalamic- Pituitary-Adrenocortical Activity by Serotonergic Agents in the Rat

Matheson¹,

Knowles²,

Gage³

et al. 1997

Pharmacology

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The effects of tandospirone, enciprazine, gepirone, buspirone (5-HT_1A agents) and carvotroline (5-HT₂) on hypothalamic-pituitary-adrenocortical activity (HPA) activity were studied. These drugs increased the plasma corticosterone levels in a dose-dependent manner. Their ED₅₀ values were 3.8, 31.8, 3.1, 3.4 and 7.0 mg/kg, respectively. Drug effects peaked between 30 min and 1 h, and plasma corticosterone levels returned to control levels after 2 h. When the drugs were given in conjunction with a rotatory stress, gepirone and enciprazine increased and carvotroline decreased plasma corticosterone levels. Dexamethasone (0.1 mg/kg) pretreatment reduced drug-activated HPA axis activity.

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A comparison of the effects of buspirone and diazepam on plasma corticosterone levels in rat

Cited by 45 publications

References 37 publications

Nociceptin/Orphanin FQ Increases Anxiety-Related Behavior and Circulating Levels of Corticosterone During Neophobic Tests of Anxiety

Nociceptin/Orphanin FQ Increases Anxiety-Related Behavior and Circulating Levels of Corticosterone During Neophobic Tests of Anxiety

Cannabinoids and Their Interactions with Diazepam on Modulation of Serum Corticosterone Concentration in Male Mice

Modification of Hypothalamic- Pituitary-Adrenocortical Activity by Serotonergic Agents in the Rat

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