A comparison of the effects of muscarinic and nicotinic anticholinergic drugs on habituation and fear conditioning in rats

Avis, Harry H.; Pert, Agu

doi:10.1007/bf00421962

Cited by 16 publications

(4 citation statements)

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“…The nicotinic antagonist mecamylamine has been found to impair memory performance of rodents in several tasks including passive avoidance and the working memory version of the radial-arm maze (Oliverio 1966;Diltz and Berry 1967;Chiappeta and Jarvik 1969;Goldberg et al 1971;Glick and Greenstein 1972;Avis and Pert 1974;Hodges etal. 1991b;Levin etal.…”

Section: Nicotinic Antagonist Effectsmentioning

confidence: 96%

Nicotinic systems and cognitive function

1992

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Nicotinic acetylcholine receptors have been found to be important for maintaining optimal performance on a variety of cognitive tasks. In humans, nicotine-induced improvement of rapid information processing is particularly well documented. In experimental animals nicotine has been found to improve learning and memory on a variety of tasks, while the nicotinic antagonist mecamylamine has been found to impair memory performance. Nicotine has been found to be effective in attenuating memory deficits resulting from lesions of the septohippocampal pathway or aging in experimental animals. Nicotinic receptors are decreased in the cortex of patients with Alzheimer's disease. Preliminary studies have found that some aspects of the cognitive deficit in Alzheimer's disease can be attenuated by nicotine. Nicotine may prove to be useful therapeutic treatment for this and other types of dementia.

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Section: Nicotinic Antagonist Effectsmentioning

confidence: 96%

Nicotinic systems and cognitive function

1992

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“…First, the two cross-dissociation groups which were tested under either scopolamine (MEC-SCOP) or mecamylamine (SCOP-MEC) did not show an appreci able increase in drinking times . Second , we have previously shown (Avis & Pert, 1974) that scopolamine and mecamylamine, at the dosages employed in this study, have no effect on the consumption of diluted sweetened condensed milk.…”

Section: Resultsmentioning

confidence: 59%

“…been impaired by mecamylamine (Goldberg et al, 1971) , an effect similar to that reported for scopolamine (Meyers, Roberts, Riciputi, & Domino, 1964 ;Suits & Isaacson, 1968). Differences, however, have appeared between the effects of these two drugs in the acquisition of two-way active avoidance (Bignami, Amarico, Frontale, & Rosie, 1971;Oliverio, 1966Oliverio, , 1967Suits & Isaacson, 1968) and in habituation (Avis & Pert , 1974).…”

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confidence: 61%

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Dissociation between scopolamine and mecamylamine during fear conditioning in rats

Pert

Avis

1974

Psychobiology

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State-dependent (dissociated) learning has been reported for both scopolamine (muscarinic anticholinergic) and mecamylamine (nicotinic anticholinergic). The purpose of this series of experiments was to ascertain whether dissociation would occur between these two anticholinergic compounds in a conditioned suppression task. In Experiment I, food-deprived rats were trained to drink sweetened condensed milk in a test chamber for 8 days. On Day 9, all rats received a single electric shock in the same chamber 20 min after injections of scopolamine, mecamylamine, or saline. Three days later, subgroups were tested for conditioned suppression under the same drug condition, the other drug condition, or saline. Conditioned suppression was found in all groups except those trained under scopolamine or mecamylamine and tested under saline or the other drug condition. Experiment II controlled for some of the variables which may have produced dissociation in the first experiment. The findings are interpreted to imply the existence of two separate cholinergic (nicotinic and muscarinic) pathways which mediate fear conditioning.

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Applications and Limitations of the Drug Discrimination Method for the Study Of Drug Abuse

Overton

1987

Methods of Assessing the Reinforcing Properties of Abused Drugs

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A comparison of the effects of muscarinic and nicotinic anticholinergic drugs on habituation and fear conditioning in rats

Cited by 16 publications

References 39 publications

Nicotinic systems and cognitive function

Nicotinic systems and cognitive function

Dissociation between scopolamine and mecamylamine during fear conditioning in rats

Applications and Limitations of the Drug Discrimination Method for the Study Of Drug Abuse

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