A comparison of the effects of electrical stimulation of the amygdala and hippocampus on subpallidal output neurons to the pedunculopontine nucleus

Tsai, C.T.; Mogenson, Gordon J.; Wu, Michael; Yang, C.R.

doi:10.1016/0006-8993(89)90139-x

Cited by 23 publications

(12 citation statements)

References 13 publications

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“…This contextdependent response to sensory information in the PPTg may rely on memory information from the hippocampus. Indeed, there have been studies that have supported the hypothesis that they are functionally connected; Tsai et al showed that a large majority of subpallidal output neurons that are activated by antidromic stimulation of the PPTg are inhibited by hippocampal stimulation (Tsai et al, 1989).…”

Section: Functional Pathways From the Hippocampus To The Vtamentioning

confidence: 97%

Integrative hippocampal and decision-making neurocircuitry during goal-relevant predictions and encoding

Mizumori

Tryon

2015

The Connected Hippocampus

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Section: Functional Pathways From the Hippocampus To The Vtamentioning

confidence: 97%

Integrative hippocampal and decision-making neurocircuitry during goal-relevant predictions and encoding

Mizumori

Tryon

2015

The Connected Hippocampus

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“…Disinhibition of mesencephalic motor pattern generators via the ventral pallidum may initiate ambulatory locomotion, especially forward locomotion, thereby translating activity in the nucleus accumbens into overt goal-directed behavior (discussed in Floresco, 2007). The majority of pallidal neurons that inhibit neurons in the pedunculopontine nucleus are inhibited by hippocampal stimulation (via activation of accumbal output to the ventral pallidum) and activated by amygdala stimulation, suggesting differential influences of limbic centers on locomotor activity (Tsai et al, 1989).…”

Section: Mesencephalic Motor Centersmentioning

confidence: 99%

Situationally appropriate behavior: translating situations into appetitive behavior modes

Behrendt¹

2013

Reviews in the Neurosciences

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“…With respect to population activity, in vivo intracellular recording studies have revealed that DA neurons are constantly bombarded with high-amplitude GABAergic inhibitory postsynaptic potentials (IPSPs) arriving at a rapid pace (Grace and Bunney, 1985). These IPSPs presumably arise from GABAergic afferents derived from the ventral pallidum, a region containing neurons that are GABAergic, fire at rapid rates (Tsai et al, 1989), and project to the midbrain DA neuron population. We have posited that the ventral pallidum, via high discharge rates and direct GABAergic projections to midbrain DA neurons, holds subsets of these neurons in a hyperpolarized, non-firing state (Floresco et al, 2001a).…”

Section: Regulation Of Dopamine System Activitymentioning

confidence: 99%

Dopamine System Dysregulation by the Ventral Subiculum as the Common Pathophysiological Basis for Schizophrenia Psychosis, Psychostimulant Abuse, and Stress

Grace

2010

Neurotox Res

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The dopamine system is under multiple forms of regulation, and in turn provides effective modulation of system responses. Dopamine neurons are known to exist in several states of activity. The population activity, or the proportion of dopamine neurons firing spontaneously, is controlled by the ventral subiculum of the hippocampus. In contrast, burst firing, which is proposed to be the behaviorally salient output of the dopamine system, is driven by the brainstem pedunculopontine tegmentum. When an animal is exposed to a behaviorally salient stimulus, the pedunculopontine tegmentum elicits a burst of action potentials in the dopamine neurons. However, this bursting only occurs in the portion of the dopamine neuron population that is firing spontaneously. This proportion is regulated by the ventral subiculum. Therefore, the ventral subiculum provides the gain, or the amplification factor, for the behaviorally salient stimulus. The ventral subiculum itself is proposed to carry information related to the environmental context. Thus, the ventral subiculum will adjust the responsivity of the dopamine system based on the needs of the organism and the characteristics of the environment. However, this finely tuned system can be disrupted in disease states. In schizophrenia, a disruption of interneuronal regulation of the ventral subiculum is proposed to lead to an overdrive of the dopamine system, rendering the system in a constant hypervigilant state. Moreover, amphetamine sensitization and stressors also appear to cause an abnormal dopaminergic drive. Such an interaction could underlie the risk factors of drug abuse and stress in the precipitation of a psychotic event. On the other hand, this could point to the ventral subiculum as an effective site of therapeutic intervention in the treatment or even the prevention of schizophrenia.

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A comparison of the effects of electrical stimulation of the amygdala and hippocampus on subpallidal output neurons to the pedunculopontine nucleus

Cited by 23 publications

References 13 publications

Integrative hippocampal and decision-making neurocircuitry during goal-relevant predictions and encoding

Integrative hippocampal and decision-making neurocircuitry during goal-relevant predictions and encoding

Situationally appropriate behavior: translating situations into appetitive behavior modes

Dopamine System Dysregulation by the Ventral Subiculum as the Common Pathophysiological Basis for Schizophrenia Psychosis, Psychostimulant Abuse, and Stress

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