A Comparison of the Effects of Ten, 5-Substituted Benzimidazolyl Carbamates on Larval Development of Three Hymenolepidid Tapeworms

An investigation of the chemotherapeutic effects of 2 anthelmintics, albendazole (ABZ, methyl 5-[propylthio]benzimidazole-2- carbamate) and mebendazole (MBZ, methyl 5-[benzoyl]benzimidazole-2-carbamate), on Hymenolepis microstoma and Hymenolepis diminuta in experimentally infected mice and rats is reported. Single (50 mg/kg) or multiple daily oral doses (50 mg kg-1 day-1 for 3 consecutive days) of MBZ had no effect on H. microstoma; at necropsy, the drug treated mice harbored appreciable numbers of the parasite in the bile duct and biliary passages. ABZ was also inactive when given as a single oral 50 mg/kg dose on day 27 PI. Better results were obtained when ABZ was administered at a dosage of 50 mg kg-1 day-1 for 3 consecutive days; the reduction in worm burden obtained with this treatment regimen was 50%. These results are in marked contrast to those obtained with the same anthelmintics against enteral H. diminuta in rats which succumbed at lower dosages. A review was made of the published reports on the pharmacokinetic behavior of these benzimidazole carbamate anthelmintics and a hypothesis for the inactivity of MBZ against H. microstoma is proposed.

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Efficacy of albendazole and mebendazole againstHymenolepis microstoma andHymenolepis diminuta

McCracken

Lipkowitz

Dronen

1992

Parasitol Res

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Comparison of the effects of imidazo[1,2-a]pyridine-2-carbamates and benzimidazole-2-carbamates on the development ofHymenolepis nana inTribolium confusum

Novak

Blackburn

1985

Experientia

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Interspecific variation of isoenzyme patterns in four Hymenolepis species (Cestoda)

Novak¹,

Taylor²,

Pip³

1989

Can. J. Zool.

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Starch gel protein electrophoresis of mass homogenates of Hymenolepis microstoma, H. diminuta, H. citelli, and H. nana revealed a large degree of isoenzymic variation in the 11 enzyme systems tested in these species. Whereas the majority of the 68 bands found in total were species specific, 23 were shared between at least two species, and 1 band was common to all four species. Cluster analysis suggested that H. microstoma is the most dissimilar of the four species and may have diverged the earliest from the common ancestral line, whereas H. citelli and H. nana were the two most similar species and may have diverged more recently. Hymenolepis diminuta was intermediate in position, but demonstrated closer affinities with H. citelli and H. nana than with H. microstoma.

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A Comparison of the Effects of Ten, 5-Substituted Benzimidazolyl Carbamates on Larval Development of Three Hymenolepidid Tapeworms

Cited by 4 publications

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Efficacy of albendazole and mebendazole againstHymenolepis microstoma andHymenolepis diminuta

Efficacy of albendazole and mebendazole againstHymenolepis microstoma andHymenolepis diminuta

Comparison of the effects of imidazo[1,2-a]pyridine-2-carbamates and benzimidazole-2-carbamates on the development ofHymenolepis nana inTribolium confusum

Interspecific variation of isoenzyme patterns in four Hymenolepis species (Cestoda)

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