A comparison of the effects of desflurane, sevoflurane and propofol on QT, QTc, and P dispersion on ECG

Kazancı, Dilek; Ünver, Süheyla; Karadeniz, Ümit; Iyican, D.; Koruk, Senem; Yilmaz, Mehmet Birhan; Erdemli, Özcan

doi:10.4103/0971-9784.51361

Cited by 41 publications

(34 citation statements)

References 30 publications

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“…The general anesthetic sevofl urane has been reported to prolong Pwd, while desfl urane has no effect on it, and propofol shortens it 1,48,49 . Pwd intervals also extend after laryngoscopy and tracheal intubation 1 .…”

Section: Discussionmentioning

confidence: 99%

Efeitos de esmolol, lidocaína e fentanil nos intervalos dispersão da onda P, QT, QTc e respostas hemodinâmicas à intubação endotraqueal durante indução com propofol: um estudo comparativo

Hancı¹,

Yurtlu²,

Karabağ³

et al. 2013

Rev. Bras. Anestesiol.

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Background and objectives: In our study we aimed to investigate the effect of esmolol, lidocaine and fentanyl on P-wave dispersion (Pwd), QT and corrected QT (QTc) durations and hemodynamic responses to endotracheal intubation during propofol induction. Methods: A total of eighty adult patients, American Society of Anesthesiologists (ASA) Physical Status I or II aged 18 to 60 years were included in this prospective, randomised, double-blind study. All patients had control electrocardiograms (ECGs) done before anesthesia induction. The patients were randomised into four equal groups. The control group (Group C) received saline 5 mL, the esmolol group (Group E) received esmolol 0.5 mg.kg -1 , the fentanyl group (Group F) received fentanyl 2 µg.kg -1 and the lidocaine group (Group L) received lidocaine 1.5 mg.kg -1 before

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Section: Discussionmentioning

confidence: 99%

Efeitos de esmolol, lidocaína e fentanil nos intervalos dispersão da onda P, QT, QTc e respostas hemodinâmicas à intubação endotraqueal durante indução com propofol: um estudo comparativo

Hancı¹,

Yurtlu²,

Karabağ³

et al. 2013

Rev. Bras. Anestesiol.

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“…Similar to our study, Higashijima et al 33 did a study on 50 spinal surgery patients, where he compared thiamylal and propofol for induction, and reported a significant shortage of QT intervals caused by propofol. Kazanci et al compared propofol, sevoflurane and desflurane in their study for induction on 46 general surgery patients and reported that propofol significantly shortens QT intervals 34 . There were no studies available that analyze QT intervals with the propofol doses we used.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Sedative Agents Used in Intensive Care Unit on Qt Interval

Avcı¹,

Gürsoy²,

Kaygusuz³

et al. 2017

Cumhuriyet Medical Journal

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SUMMARYObjective: The aim of this research is the effects of sedative drugs which are used on intensive care unit (ICU) patients on QT interval. Method: 90 patients who were hospitalized at ICU due to respiratory insufficiency and connected to mechanic ventilator were included. After the respiratory and cardiac monitorizations were enabled on patient with respiratory insufficiency in ICU, 12 derivations ECG's were recorded, systolic blood pressure (SBP), diastolic blood pressure(DBP), mean arterial blood pressure(MABP), heart rate(HR) and peripheric oxygen saturation (SpO2) values were recorded simultaneously. These values were used as base. At 1st and 12th hours of sedation (midazolam, propofol or dexmedetomidin), 12 derivations ECG's were recorded and again, SBP, DBP, MBP, HR and SpO2 values were recorded. ECG's were recorded at the speed of 25mm/s and at the height of 1 mV. Among the derivations in ECG recordings, the longest QT interval was measured by 2 anesthesiologists who don't know the groups and by measuring the RR interval on the same derivation, QTc (corrected QT) interval was measured with Bazzet formula. (QTc=QT intervali / √ RR interval) .Measured QT and QTc values were recorded. Results: When HR's at 12th hour were evaluated, HR at dexmedetomidin group was lower than both midazolam and propofol groups' HR and this was statistically significant (p<0,05). When MABP's at 12th hour were evaluated, MABP in propofol group was lower than dexmedetomidin group and this was statistically significant (p<0,05). When SpO2 values at 12th hour were evaluated, SpO2 values in midazolam group was significantly lower than the other 2 groups' SpO2 values. (p<0,05). For QT interval; dexmedetomidin prolonged the interval more than the other 2 agents both at 1st and 12th hours and this was statistically significant (p<0,05). There was statistically significant difference in QT intervals between propofol and midazolam groups at 12th hours (p<0,05). When QTc intervals were evaluated; only QTc values at 12th hour were different between different sedative agents and the QTc values in these groups belong to these different sedative agents were different each other and this was statistically different (p<0,05). Dexmedetomidin prolonged QTc mostly however propofol shows favorable efficacy by shortening the QTc interval. Conclusions: In our opinion, propofol is a good alternative sedative agent for dexmedetomidin and midazolam in patients with long QT interval because it shortens the QT interval however dexmedetomidin and midazolam can cause cardiac arrhythmia by prolonging QT interval. When making drug choice for sedation in ICU, patient's clinical situation, hemodynamic parameters and cardiac monitorization must be considered. Keywords: Propofol, midazolam, dexmedetomidine, sedation, QT interval, . 418ÖZET Amaç: Bu çalışmanın amacı, yoğun bakım ünitelerinde (YBÜ) kullanılan sedatif ajanların QT intervali üzerine olan etkilerini araştırmaktır. Yöntem: Çalışmaya solunum yetmezliği nedeniyle yoğun bakım ünitesine alınmış, mekan...

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“…The general anesthetic sevofl urane has been reported to prolong Pwd, desfl urane to have no effect on it, and propofol to shorten it [22][23][24] . At the same time, our literature survey found no study that investigated the effects of local or spinal anesthesia on Pwd.…”

Section: Discussionmentioning

confidence: 99%

Efeito de levobupivacaína e bupivacaína nas dispersões da onda P, QT e QT corrigido (QTc) em cesariana

Deniz¹,

Okyay²,

Hancı³

et al. 2013

Rev. Bras. Anestesiol.

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Background and Objectives: In our study we aimed to investigate the effect of bupivacaine and levobupivacaine on QT, corrected QT (QTc), and P wave dispersion durations during spinal anesthesia in cesarean section. Methods: Sixty parturients scheduled for elective cesarean section in ASA I-II risk groups were included in the study. Baseline electrocardiographic (ECG) records of the patients were obtained in the operation room. Heart rate (HR), non-invasive blood pressure (NIBP), peripheral oxygen saturation (SpO 2 ) and respiration rates (RR) were recorded. Venous cannulation was performed with 18G cannula and fl uid preload made with 10 mL.kg -1. Lactated Ringer solution. After fl uid preload, second ECG recordings were taken and the patients were randomly separated into two groups. Group B (n = 30) received 10 mg of bupivacaine and Group L (n = 30) received 10 mg of levobupivacaine for spinal anesthesia. ECG recordings were repeated at 1, 5 and 10 minutes after spinal block. HR, NIBP, SpO 2 , RR and sensory block levels were also recorded at the same time intervals. At predetermined time intervals of spinal anesthesia, P wave dispersion (Pwd), QT dispersion (QTd), and QTc dispersion (QTcd) durations were measured from ECG records. QT and QTc durations are calculated with Bazzett formula.

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A comparison of the effects of desflurane, sevoflurane and propofol on QT, QTc, and P dispersion on ECG

Cited by 41 publications

References 30 publications

Efeitos de esmolol, lidocaína e fentanil nos intervalos dispersão da onda P, QT, QTc e respostas hemodinâmicas à intubação endotraqueal durante indução com propofol: um estudo comparativo

Efeitos de esmolol, lidocaína e fentanil nos intervalos dispersão da onda P, QT, QTc e respostas hemodinâmicas à intubação endotraqueal durante indução com propofol: um estudo comparativo

The Effects of Sedative Agents Used in Intensive Care Unit on Qt Interval

Efeito de levobupivacaína e bupivacaína nas dispersões da onda P, QT e QT corrigido (QTc) em cesariana

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