A comparison of the effects of dietary spray-dried bovine colostrum and animal plasma on growth and intestinal histology in weaner pigs

King, Melanie; Morel, P. C. H.; Pluske, J.R.; Hendriks, W.H.

doi:10.1016/j.livsci.2008.04.001

Cited by 26 publications

(30 citation statements)

References 18 publications

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“…FDOI-based diets have also been shown to increase villi and crypt goblet cell numbers throughout the gut in healthy rats (Balan, 2010). A decline in goblet cell numbers after infection has also been reported in a murine model infected with Citrobacter rodentium (King et al, 2008;Lindé n et al, 2008). …”

Section: Discussionmentioning

confidence: 66%

Dietary supplementation with ovine serum immunoglobulin attenuates acute effects on growth, organ weights, gut morphology and intestinal mucin production in the growing rat challenged with Salmonella enteritidis

Balan

Han

Rutherfurd

et al. 2011

Animal

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The aim was to determine the effect of orally administered ovine serum immunoglobulin (Ig) on growth performance, organ weight, gut morphology and mucin production in the Salmonella enteritidis -gavaged growing rat. Four groups consisted of non-gavaged rats fed a casein-based control basal diet (BD) and three groups of rats gavaged with 1 3 10 7 CFU S. enteritidis and fed a casein-based diet, a diet containing freeze-dried ovine Ig (FDOI) or a casein-based diet containing inactivated ovine Ig (IOI). The rats were randomly allocated to one of the four groups (n 5 15/group) and received their respective diets for an 18-day experimental study. Gavaging took place on day 15. Average daily gain and body gain : feed ratio (post-gavage, 3 days) were significantly (P , 0.05) higher for the Salmonella-challenged rats fed the FDOI diet compared to those fed the BD and IOI diets. At the end of the study, the small intestine and colon were significantly (P , 0.05) heavier for the gavaged rats fed the FDOI diet compared to the gavaged rats fed either the BD or IOI diet. Moreover, the relative weights of the caecum, liver and spleen of the gavaged rats fed the BD or IOI diet were significantly (P , 0.05) heavier compared to the gavaged rats fed the FDOI diet. Generally, the gavaged rats fed the FDOI diet had significantly (P , 0.05) higher goblet cell counts and luminal mucin protein contents than the gavaged rats fed either the BD or IOI diet and had a more functional gut morphology. Overall, the FDOI fraction prevented the acute effects of S. enteritidis.

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Section: Discussionmentioning

confidence: 66%

Dietary supplementation with ovine serum immunoglobulin attenuates acute effects on growth, organ weights, gut morphology and intestinal mucin production in the growing rat challenged with Salmonella enteritidis

Balan

Han

Rutherfurd

et al. 2011

Animal

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“…Mucins are produced in the gut by specialized goblet cells and an enhanced presence of goblet Other investigators (Sherman et al, 1985) have shown that chronic protein depletion or protein-energy undernutrition decrease the number of goblet cells and mucin synthesis in the proximal small intestine of rodents and piglets. Recently, King et al (2008) reported that feeding pigs with either colostrum or dried plasma resulted in an increase of villus and crypt goblet cells.…”

Section: Discussionmentioning

confidence: 99%

“…Animal plasma or colostrum (a major source of Ig) fed pigs have been shown to have a higher number of intestinal goblet cells (King et al, 2008). Recently, we have reported that rats receiving FDOI had a relative increase in probiotic bacteria such as Lactobacillus species in the gut digesta (Balan, 2011).…”

Section: Discussionmentioning

confidence: 99%

“…The mucus layer is affected by numerous dietary components and the reported beneficial effects of dietary Ig on gut health may be due, at least in part, to effects -E-mail: p.j.moughan@massey.ac.nz on the mucus layer (Claustre et al, 2002;Dock-Nascimento et al, 2007;Han et al, 2008;King et al, 2008). Recently, we have reported that feeding a freeze-dried ovine serum Ig preparation selectively improves growth performance, the weight of some digestive organs and gut morphology in the growing rat (Balan et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

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Dietary supplementation with ovine serum immunoglobulin is associated with an increased gut luminal mucin concentration in the growing rat

Balan

Han

Singh

et al. 2011

Animal

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The mucus layer covering the gut epithelium is pivotal to host defence and is affected by various dietary components. Part of the reported beneficial effect of dietary immunoglobulins (Igs) on gut health may be due to effects on the gut mucus layer. The aim was to determine whether orally administered ovine serum Ig influence goblet cell count, mucin gene expression and digesta mucin protein content in the gut of the growing rat. Fourteen Sprague-Dawley male growing rats were used in a 21-day study and were fed either a casein-based control diet (CON; no Ig) or a similar diet but containing freeze-dried ovine Ig (FDOI). Daily food intake and growth rate were not affected by the dietary treatments. When compared to the rats consuming CON diet, those consuming the FDOI diet had significantly (P , 0.05) more intact and cavitated goblet cells in the intestinal villi. A similar result was found for crypt goblet cells in the small intestine and colon. Ileal Muc2, Muc3, Muc4 and stomach Muc5Ac mRNA expressions for the FDOI animals were higher (P , 0.05) compared to the the CON animals. Mucin protein content was higher (P , 0.05) in the stomach, ileum and colonic digesta of rats fed the FDOI diet. In conclusion, orally administered FDOI influenced gut mucins in the growing rat as evidenced by increased mucin gene expression and digesta mucin protein concentrations as well as an increased goblet cell count.

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“…Com as vilosidades menores e as criptas mais profundas, temse menor absorção e maior secreção, o que predispõe o leitão à diarréia pós-desmame (HAMPSON, 1986). As imunoglobulinas e a albumina podem atuar como fatores de crescimento da epiderme e contribuir para a redução da atrofia das vilosidades intestinais (KING et al, 2008), assim, o plasma sanguíneo (LORA GRAÑA et al, 2010), probióticos (CORREIA et al, 2010), prébióticos (BARROS et al, 2008, o leite em pó e a gema de ovo podem atuar de maneira trófica nas vilosidades do intestino delgado. Este tipo de mecanismo tem sido relatado com leitões desmamados aos 21 dias de idade ou menos.…”

Section: Introductionunclassified

Efeitos de plasma sanguíneo sobre vilosidades, desenvolvimento bacteriano e desempenho de leitões criados em condições de desafio pós-desmame aos 35 dias

Barbosa

Silva

Ferreira

et al. 2012

Rev. bras. saúde prod. anim.

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Rev. Bras. Saúde Prod. Anim., Salvador, v.13, n. SUMMARYWith the objective to determine the effects of spray-dried plasma on intestinal villi and bacterial growth in the small intestine, as well as on performance of piglets weaned at 35 days old, 24 piglets were randomly assigned in an experimental block design with four treatments (0.0; 2.5; 5.0, and 7.5% spray dried plasma), six replicates and one piglet per experimental unit. Differences were observed among treatments with respect to weight gain, feed conversion, E. coli colony-forming units, and villus height. Pigs fed diets containing spray dried plasma gained more weight and had less E. coli in the small intestine than piglets fed the control diet. The piglets fed the diets containing 5.0 or 7.5% plasma showed better feed conversion compared to those receiving the control diet. Piglets fed the diets containing 2.5; 5.0 or 7.5% plasma received 45.0; 75.0, and 70.0% lesser doses of antibiotics compared to piglets in the control treatment. The levels of 2.5% and 7.5% plasma in the diet resulted in increases in villus height in the duodenum and jejunum. The inclusion of spray-dried plasma in diets for health challenged piglets weaned at 35 days of age has a direct effect on the formation of E.

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A comparison of the effects of dietary spray-dried bovine colostrum and animal plasma on growth and intestinal histology in weaner pigs

Cited by 26 publications

References 18 publications

Dietary supplementation with ovine serum immunoglobulin attenuates acute effects on growth, organ weights, gut morphology and intestinal mucin production in the growing rat challenged with Salmonella enteritidis

Dietary supplementation with ovine serum immunoglobulin attenuates acute effects on growth, organ weights, gut morphology and intestinal mucin production in the growing rat challenged with Salmonella enteritidis

Dietary supplementation with ovine serum immunoglobulin is associated with an increased gut luminal mucin concentration in the growing rat

Efeitos de plasma sanguíneo sobre vilosidades, desenvolvimento bacteriano e desempenho de leitões criados em condições de desafio pós-desmame aos 35 dias

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