1995
DOI: 10.1007/bf00202165
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A comparison of the effects of prednisolone and mianserin on ventilatory, exercise and psychometric parameters in patients with chronic obstructive pulmonary disease

Abstract: There is controversy as to whether effects on mood play a role in mediating the response to corticosteroids in chronic obstructive pulmonary disease (COPD). If alterations in mood are important, it is conceivable that psychotropic drugs such as mianserin might produce similar responses to prednisolone in patients with COPD. Twelve patients age 62.5 y, with FEV1 29% of predicted and < 15% reversibility to salbutamol completed a randomised, double-blind crossover study. After an initial three week placebo run-in… Show more

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Cited by 5 publications
(1 citation statement)
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“…Procedures that may evaluate (not exclusively) carotid body function are “6 mins walking test” and hypoxic ventilatory response ( Grove et al, 1995 ; Niewinski et al, 2021 ), which are well-validated, and newer tests are being proposed ( Bhattacharyya et al, 2020 ). In addition, hypoxic pulmonary vasoconstriction and hypoxic or high-altitude bronchoconstriction depend (also) on serotonin release and the activation of pulmonary neuroendocrine cells, for which a specific test is lacking.…”
Section: Clinical Testing Of Chemosensory Functionsmentioning
confidence: 99%
“…Procedures that may evaluate (not exclusively) carotid body function are “6 mins walking test” and hypoxic ventilatory response ( Grove et al, 1995 ; Niewinski et al, 2021 ), which are well-validated, and newer tests are being proposed ( Bhattacharyya et al, 2020 ). In addition, hypoxic pulmonary vasoconstriction and hypoxic or high-altitude bronchoconstriction depend (also) on serotonin release and the activation of pulmonary neuroendocrine cells, for which a specific test is lacking.…”
Section: Clinical Testing Of Chemosensory Functionsmentioning
confidence: 99%