A Comparison of the Efficacy of 4% Articaine with 1:100,000 Epinephrine and 2% Lidocaine with 1:80,000 Epinephrine in Achieving Pulpal Anesthesia in Maxillary Teeth with Irreversible Pulpitis

A Prospective Randomized Trial of Different Supplementary Local Anesthetic Techniques after Failure of Inferior Alveolar Nerve Block in Patients with Irreversible Pulpitis in Mandibular Teeth

“…The current study produced similar success for both treatments after supplementary techniques, and this suggests that success is not affected by the selection of treatment in patients with irreversible pulpitis in mandibular permanent teeth. This is in contrast to the maxilla, in which the success of infiltration anesthesia in teeth with irreversible pulpitis has been shown to be greater for extraction compared with pulp extirpation (27). This might be the result of the extra local anesthetic dose given in the palatal region for maxillary teeth before extraction; however, inherent differences between regional block and infiltration techniques could also have an influence.…”

Does Articaine Provide an Advantage over Lidocaine in Patients with Symptomatic Irreversible Pulpitis? A Systematic Review and Meta-analysis

“…Seven studies were excluded because they did not meet the inclusion criteria: not a randomized double-blind study (28)(29)(30)(31), did not compare articaine and lidocaine (29,32,33), or did not provide dichotomous data (34). The remaining 10 studies met the inclusion criteria and were included in the meta-analysis (35)(36)(37)(38)(39)(40)(41)(42)(43)(44).…”

The impact of cardiovascular drugs on the efficacy of local anesthesia in dentistry

“…Local clinical parameters of anesthesia were monitored only in healthy subjects through comparative analysis of two different anesthetics given by the same anesthetic technique or two different anesthetic techniques using the same anesthetic 12,13 . Two in vitro studies have recently demonstrated that antihypertensives propranolol and verapamil cause local anesthesia 14,15 .…”