A comparison of the half-life of inorganic and organic tin in the mouse

Brown, Richard A.; Nazario, Cruz M.; Tirado, R.S. de; Castrillon, Jose; Agard, E.T.

doi:10.1016/0013-9351(77)90004-4

Cited by 30 publications

(9 citation statements)

References 10 publications

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“…This is quite conceivable because Sn when given orally will be absorbed in the gastrointestinal tract only poorly ( Johnson and Greger 1982), and absorbed tin would be excreted into faeces rather than urine (Hiles 1974). It should also be taken into account that the biological half-life for excretion of tin, being in the order of days in experimental animals (Hiles 1974;Brown et al 1977), may suggest that time would be too short for Sn-U to respond to the Sn-D taken on the previous day (note that urine samples were collected on the next day of food duplicate collection). Jiang et al (2000) recently reported elevated level of total tin in the urine of the victims of tin poisoning, but the causative agents were organo-tin compounds (of which precise chemical names were not reported).…”

Section: Discussionmentioning

confidence: 98%

Dietary intake of tin in Japan, and the effects on intake of canned food and beverage consumption

Shimbo¹,

Matsuda‐Inoguchi²,

Watanabe³

et al. 2007

Food Additives and Contaminants

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The study reported herein was initiated to examine dietary tin intake (Sn-D) in Japan to elucidate the possible effects of consumption of canned food (including beverages) on Sn-D, and to compare the intake among regions and between the two sexes in reference to the current provisional tolerable weekly intake and intake in other countries. Urinary tin levels (Sn-U) were also studied. Duplicate diet samples (24 h) together with records of food intake were collected in 1999-2004 from 111 adult residents in four areas of Japan. After exclusion of incomplete samples, 95 valid samples were subjected to determination of tin by inductively coupled plasma mass spectrometry (ICP-MS) after acid digestion. Among the 95 cases, 37 women additionally provided urine samples. Distribution of Sn-D was markedly skewed. Median Sn-D was 5.6 microg day(-1) for total subjects, which was about one-tenth of the values previously reported for the Japanese population; the difference was most probably attributable to the difference in the methods of determination. Consumption of canned foods led to a substantial increase in Sn-D. Thus, the median Sn-D for canned food consumers of 35.7 microg day(-1), was eight-fold higher than the median Sn-D for non-consumers of 4.5 microg day(-1). Sn-U (as corrected for creatinine concentration) distributed log-normally with a geometric mean of 2.0 microg (g cr)(-1). No effect of canned food consumption was evident on Sn-U. When compared internationally, Sn-D for the Japanese population was substantially lower than Sn-D for populations in other industrialized countries.

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Section: Discussionmentioning

confidence: 98%

Dietary intake of tin in Japan, and the effects on intake of canned food and beverage consumption

Shimbo¹,

Matsuda‐Inoguchi²,

Watanabe³

et al. 2007

Food Additives and Contaminants

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“…Inorganic tin (Sn) is a unique metal in the sense that it has been considered least toxic to humans [1], possibly because absorption from the gastrointestinal (GI) tract is limited and passage through the tract is rapid [2] and accumulation in the tissue is low [3], although the half life is substantially long, e.g., 29 days in mice [4]. Sn may, however, cause acute GI tract problems, such as abdominal distension, pain and vomiting both in experimental animals [5] and in humans [6] when ingested at a high dose [7].…”

Section: Introductionmentioning

confidence: 99%

Dietary tin intake and association with canned food consumption in Japanese preschool children

Shimbo

Watanabe

Nakatsuka

et al. 2012

Environ Health Prev Med

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Canned foods were the major source of dietary Sn intake for preschool children studied. Thus, median Sn-D was higher for the canned food consumers (10.6 μg/day) than for non-consumers of canned foods (2.5 μg/day). Sn-D by canned food-consuming children was, however, substantially lower than the provisional tolerable weekly intake. No difference was detected in Sn levels in urine between canned food-consuming and non-consuming children.

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“…The disappearance of radioactivity following intraperitoneal injection of a tracer of 113 SnCl 2 into 5 Swiss mice was followed by whole body counting. The biological half life of tin was estimated as 29 days (Brown et al, 1977). Intravenous injection of single bolus doses of 2 mg/kg body weight of either Sn 2+ or Sn 4+ (citrate and fluoride) resulted in the excretion of 30% of the dose in the urine, with 11% and 0% of Sn 2+ and Sn 4+ eliminated in the bile (Hiles, 1974).…”

Section: Animalsmentioning

confidence: 99%

Opinion of the Scientific Panel on Dietetic products, nutrition and allergies [NDA] related to the tolerable upper intake level of tin

2005

EFSA Journal

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A comparison of the half-life of inorganic and organic tin in the mouse

Cited by 30 publications

References 10 publications

Dietary intake of tin in Japan, and the effects on intake of canned food and beverage consumption

Dietary intake of tin in Japan, and the effects on intake of canned food and beverage consumption

Dietary tin intake and association with canned food consumption in Japanese preschool children

Opinion of the Scientific Panel on Dietetic products, nutrition and allergies [NDA] related to the tolerable upper intake level of tin

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