In attention/hyperactivity and aggressive behavior problems were measured in 335 children from school entry throughout adolescence, at 3-year intervals. Children were participants in a high-risk prospective study of substance use disorders and comorbid problems. A parallel process latent growth model found aggressive behavior decreasing throughout childhood and adolescence, whereas inattentive/hyperactive behavior levels were constant. Growth mixture modeling, in which developmental trajectories are statistically classified, found two classes for inattention/hyperactivity and two for aggressive behavior, resulting in a total of four trajectory classes. Different influences of the family environment predicted development of the two types of behavior problems when the other behavior problem was held constant. Lower emotional support and lower intellectual stimulation by the parents in early childhood predicted membership in the high problem class of inattention/hyperactivity when the trajectory of aggression was held constant. Conversely, conflict and lack of cohesiveness in the family environment predicted membership in a worse developmental trajectory of aggressive behavior when the inattention/hyperactivity trajectories were held constant. The implications of these findings for the development of inattention/hyperactivity and for the development of risk for the emergence of substance use disorders are discussed.A cluster of child problems including inattention, disorganization, hyperactivity, and impulsivity present serious dilemmas for our society. These problems tend to co-occur and, when sufficiently severe, are diagnosed clinically as attention-deficit/hyperactivity disorder (ADHD; American Psychiatric Association [APA], 2000). Clinical diagnosis of ADHD is associated with serious impairment in multiple domains (Johnston, Murray, Hinshaw, Pelham, & Hoza, 2002) and risk for poor long-term outcome (Klein & Mannuzza, 1991) including development of later substance use disorders (Zucker & Gomberg, 1986). Treatment of attention problems and hyperactivity has led to increased rates of medication of children in the United States (Robison, Sclar, Skaer, & Galin, 1999) and associated controversy (Searight & McLaren, 1998). As a result, understanding the antecedents of these problems is an important priority.Yet the determinants of this cluster of childhood problems are far from well understood. Twin and adoption studies indicate that heritability of normal and severe levels of these behavior problems is substantial (Loney, Paternite, Schwartz, & Roberts, 1997) and neuropsychological correlates are becoming more clearly delineated (Nigg, 2001). At the same time, it is recognized that epigenetic processes, including family context effects, must also be better understood to
NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript fully account for the developmental trajectory of these difficulties (Whalen & Henker, 1999). Indeed, even heritable processes are likely to exert at least part of the...