2019
DOI: 10.1016/j.ijpharm.2019.02.041
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A comparison of the immune responses induced by antigens in three different archaeosome-based vaccine formulations

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Cited by 39 publications
(56 citation statements)
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“…We have shown, in previous studies, that both lipid formulations are capable of inducing comparable immune responses to numerous antigens [11,18,23]. Most recently, we compared different archaeosome vaccine formulations and discovered that admixing antigen and archaeosomes induced similar or superior immune responses to an encapsulated formulation [26]. In a prophylactic vaccination influenza challenge model, we compared formulations that were composed of empty archaeosomes admixed with antigen with the conventional antigen entrapped archaeosomes and again observed comparable immune responses as well as similar protection from the influenza challenge [11].…”
Section: Discussionmentioning
confidence: 91%
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“…We have shown, in previous studies, that both lipid formulations are capable of inducing comparable immune responses to numerous antigens [11,18,23]. Most recently, we compared different archaeosome vaccine formulations and discovered that admixing antigen and archaeosomes induced similar or superior immune responses to an encapsulated formulation [26]. In a prophylactic vaccination influenza challenge model, we compared formulations that were composed of empty archaeosomes admixed with antigen with the conventional antigen entrapped archaeosomes and again observed comparable immune responses as well as similar protection from the influenza challenge [11].…”
Section: Discussionmentioning
confidence: 91%
“…Archaeal lipid adjuvants are a good potential candidate for use in combination with CPI's, as evidenced by their proven safety and efficacy in mice [19,44]. In multiple pre-clinical studies, they have been shown to activate antigen-specific CD8 + T cell responses [15,19,26,27] and generate protective immunity in tumor models, e.g., B16-OVA melanoma [7,13,19,23,26,27], and against multiple infectious diseases, e.g., H1N1 influenza [11], Listeria monocytogenes [7,12], Trypanosoma cruzi [13] and Mycobacterium tuberculosis [14]. When compared to commonly used commercial adjuvants, such as Poly(I:C) or Montanide, archaeal lipid vaccines were found to elicit equal or greater antigen specific CD8 + T cell-mediated cytotoxicity and IgG responses [10].…”
Section: Discussionmentioning
confidence: 99%
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“…A recent comparison of SLA to a wide panel of commercial adjuvants (e.g., aluminum salts, TLR agonists, and water/oil emulsions) when paired with the model antigens ovalbumin and HBsAg demonstrated that SLA archaeosome formulations had robust adjuvant activity that was superior to many of the other tested adjuvants [10]. Interestingly, a novel SLA archaeosome formulation, whereby the antigen is simply admixed with preformed SLA archaeosomes, has also been shown to stimulate equal or superior antigen-specific responses as formulations where the antigen is entrapped within the archaeosome [20]. As the efficiency of antigen entrapment within archaeosomes formulations is typically variable and relatively low (5-40%) [21,22], this new admixed formulation provides a convenient easy to mix format with no loss of antigen during the formulation process, thereby reducing costs and standardizing the amount of archaeal lipid in the final vaccine formulations.…”
Section: Introductionmentioning
confidence: 99%