A Comparison of the Immunologic Responses of Normal and Atopic Individuals to Parenterally Injected, Alum Precipitated Protein Antigen

Salvaggio, John E.; Leskowitz, Sidney

doi:10.1159/000229578

Cited by 25 publications

(9 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In past studies, it has not been possi ble to demonstrate differences between the responses of atopic and non-atopic subjects when overwhelming quantities of antigenic material were injected. In those circum stances, it has been shown that pneumococ cal polysaccharide |5, 15 1. dextran [5] and RNase [13] are capable of sensitizing be tween 60 and 100% of non-atopic subjects. On the other hand, an injection dose of tim othy pollen which sensitized only 3 out of 12 non-atopic subjects was shown by Feinberg et al [3] to be capable of sensitizing all of 13 atopic subjects.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the Atopic Background between Allergic and Non-Allergic Beekeepers

Miyachi

Lessof

Kemeny

et al. 1979

Int Arch Allergy Immunol

View full text Add to dashboard Cite

A study was carried out on beekeepers and their families. 34 subjects with a history of bee sting allergy and also a positive radioallergosorbent test (RAST) to honey bee venom were compared with 47 subjects with neither. 16 subjects in the bee allergy group (47%) had a history of atopic diseases as compared to 6 (13%) in the control group (p < 0.01). 15 in the bee allergy group (44%) had at least one positive RAST to three common inhalant allergens as compared to 5 (11%) in the control group (p < 0.01). These results suggest that, although bee sting allergy frequently affects non-atopic subjects, sensitization among beekeepers and their families occurs more readily in atopies. It is notable that a large proportion of patients injected with foreign proteins (the control group) either never develop venom-specific IgE antibodies or have suppressed their production.

show abstract

Section: Discussionmentioning

confidence: 99%

Comparison of the Atopic Background between Allergic and Non-Allergic Beekeepers

Miyachi

Lessof

Kemeny

et al. 1979

Int Arch Allergy Immunol

View full text Add to dashboard Cite

show abstract

“…Other studies (22,23) showed that asthmatics were more likely to develop detectable circulating antibody after nasal instillation of antigen than were control subjects, but similar levels when the antigen was given subcutaneously, favoring enhanced mucosal absorption. Similar conclusions were reached by Buckle and Cohen (24), who attempted to examine the absorption of antigen across nasal mucosa in * P'io, PI25.…”

Section: Regionalmentioning

confidence: 97%

Respiratory Mucosal Permeability in Asthma

Elwood¹,

Kennedy²,

Belzberg³

et al. 1983

Am Rev Respir Dis

View full text Add to dashboard Cite

The permeability of respiratory mucosa to technetium-labeled diethylenetriamine pentacetic acid (99mTc-DTPA) was measured in 10 clinically stable chronic asthmatics and the results were compared with those in 9 nonasthmatic control subjects. Nonspecific bronchial reactivity was measured using methacholine, and the PC20 was calculated. The intrapulmonary distribution and dose of the inhaled 99mTc-DTPA was determined by a gamma camera and the half-life of the aerosolized label in the lung was calculated. The accumulation of radioactivity in the blood was monitored and a permeability index was calculated at 10, 25, and 60 min after aerosolization. Despite marked differences in airway reactivity, no differences in either parameter of permeability could be detected between the asthmatics and the control group. It is concluded that clinically stable asthmatics do not demonstrate increase mucosal permeability to small solutes when compared with normal subjects.

show abstract

“…This finding might be explained by postulating that immediate wheal and erythema skin reactivity in bagassosis is coincidentally within the framework of the immune response and that mere prolonged exposure to moldy bagasse is sufficient for its development even in the absence of precipitating antibody or overt disease. In other stu dies in which human volunteers were sensitized to purified protein antigens, it was shown that the sequence of response was immediate wheal and flare skin reactivity, followed by symptoms, and detect able circulating antibody (precipitating or nonprecipitating) in that order (17,18). Thus, it is possible that unaffected sugar cane industry workers who manifest positive immediate reactivity to ba gasse extracts will develop symptoms of bagassosis with further ex posure, but this cannot be predicted with any degree of certitude.…”

Section: Discussionmentioning

confidence: 99%