A comparison of the pathological, clinical and radiographical, features of cryptogenic organising pneumonia, acute fibrinous and organising pneumonia and granulomatous organising pneumonia

Feinstein, Marc B.; DeSouza, Shilpa A.; Moreira, André L.; Stover, Diane E.; Heelan, Robert T.; Iyriboz, Tunc; Taur, Ying; Travis, William D.

doi:10.1136/jclinpath-2014-202626

Cited by 47 publications

(53 citation statements)

References 17 publications

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“…Poor outcomes are associated with patients requiring mechanical ventilation [1]. Of the 51 deaths reported in the literature, 6 were unrelated to AFOP [1,2,9,13,[19][20][21]26,27,35,44,46]. Of those that died, 12 required mechanical ventilation; in 37 cases, the use of mechanical ventilation was not specified.…”

Section: Discussionmentioning

confidence: 99%

Life after acute fibrinous and organizing pneumonia: a case report of a patient 30 months after diagnosis and review of the literature

Kuza

Matheos

Kathman

et al. 2016

Journal of Critical Care

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Acute fibrinous and organizing pneumonia (AFOP) is a rare histologic interstitial pneumonia pattern recently described in the literature with fewer than 120 cases published. AFOP is often difficult to diagnose and may be mistaken for other pulmonary disorders such as interstitial pneumonias or pneumonitides. Patients often present with vague symptoms of cough, dyspnea, hemoptysis, fatigue, and occasionally respiratory failure. Radiological findings show diffuse patchy opacities and ground glass appearance of the lungs. On histologic examination, intra-alveolar fibrin balls are observed. We discuss a case of a man who presented with hemoptysis and dyspnea and whose open lung biopsy revealed AFOP. We will describe the presentation, diagnosis, and post-discharge course, and review the current literature. There are only 4 cases which have reported the patients' course of disease after 1 year, the longest being 2 years. To our knowledge, this is the only case of AFOP in the literature that describes the course of a patient more than 2 years after the diagnosis of AFOP, and is the most comprehensive review of the current literature.

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Section: Discussionmentioning

confidence: 99%

Life after acute fibrinous and organizing pneumonia: a case report of a patient 30 months after diagnosis and review of the literature

Kuza

Matheos

Kathman

et al. 2016

Journal of Critical Care

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“…More recently, Feinstein et al . compared 10 patients with a histological pattern of AFOP with 36 patients with cryptogenic organizing pneumonia (COP) . Four AFOP patients were male; the mean age was 59.6 years.…”

Section: Afopmentioning

confidence: 99%

“…However, in some cases, focal or diffuse organizing pneumonia predominates, in keeping with the outcome dichotomy described above. Traction bronchiectasis and fibrosis can also develop . AFOP manifesting as a solitary mass has been reported .…”

Section: Afopmentioning

confidence: 99%

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Rare idiopathic interstitial pneumonias: LIP and PPFE and rare histologic patterns of interstitial pneumonias: AFOP and BPIP

et al. 2015

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In the 2013 reclassification of the idiopathic interstitial pneumonias (IIPs), two rare IIPs (idiopathic lymphoid interstitial pneumonia (LIP), idiopathic pleuroparenchymal fibroelastosis (IPPFE)) and two rare histologic patterns (acute fibrinous and organizing pneumonia (AFOP), bronchiolocentric pattern of interstitial pneumonia (BPIP)) are described. All these entities are rare with small series published to date, mostly containing primary and secondary forms of disease. LIP is histologically characterized by diffuse polyclonal lymphoid cell infiltrate surrounding the airways and expanding the interstitium. Thin-walled cysts and diffuse ground glass are considered the typical radiologic features. The clinical course is highly variable with corticosteroid responsiveness evident in approximately half of cases. IPPFE is defined histologically by coexisting upper lobe pleural and intraalveolar fibrosis with elastosis. Dense subpleural irregular fibrosis and consolidation are the cardinal radiologic features. A history of recurrent lower respiratory tract infection is frequent. Responses to immunomodulation have not been reported and the rate of progression appears to be highly variable. AFOP is a rare histologic pattern lying within the spectrum of acute/subacute lung injury, characterized by organizing pneumonia and intra-alveolar fibrin deposition without hyaline membranes. BPIP is characterized histologically by fibrosis and/or inflammation confined to the alveolar interstitium around bronchovascular bundles, overlapping with peribronchial metaplasia and fibrosis in some series. Currently, AFOP and BPIP are both best viewed as histological entities rather than true clinical disorders, in the absence of characteristic associated imaging patterns and clinical features.

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“…The CT findings include symmetric, bilateral ground-glass opacity, and nodular areas of consolidation. 44 These findings may be seen in isolation or in combination. These radiographic findings mirror those of both DAD and OP (Fig.…”

Section: Acute Fibrinous Organizing Pneumoniamentioning

confidence: 99%

Imaging of Acute Lung Injury

Elicker¹,

Jones

Naeger

et al. 2016

Radiologic Clinics of North America

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A comparison of the pathological, clinical and radiographical, features of cryptogenic organising pneumonia, acute fibrinous and organising pneumonia and granulomatous organising pneumonia

Abstract: AFOP and GOP, a newly described OP form, possess clinical and pathological findings that set it apart from a COP, suggesting an emerging spectrum of OP.

Cited by 47 publications

References 17 publications

Life after acute fibrinous and organizing pneumonia: a case report of a patient 30 months after diagnosis and review of the literature

Life after acute fibrinous and organizing pneumonia: a case report of a patient 30 months after diagnosis and review of the literature

Rare idiopathic interstitial pneumonias: LIP and PPFE and rare histologic patterns of interstitial pneumonias: AFOP and BPIP

Imaging of Acute Lung Injury

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