A comparison of the relationships of the glucose tolerance test and the glycated haemoglobin assay with diabetic vascular disease in the community. The Islington Diabetes Survey

Point: A Glucose Tolerance Test Is Important for Clinical Practice

“…All three of these studies show that fasting glucose is clearly the least predictive glycemic parameter for mortality. Also, the earlier data from the Islington study in the U.K. are in keeping with this notion (20). M e i g s e t a l .…”

Diagnosing diabetes mellitus - do we need new criteria?

“…In both studies all three measures had similar associations with peripheral vascular disease [46,47]. In Islington however, the 2-h glucose was most strongly associated with major coronary heart disease [46]. In the Paris Prospective Study, the incidence of fatal cardiovascular disease was related to the fasting and 2-h plasma glucose concentrations at a baseline examination.…”

“…The relationships of fasting and 2-h plasma glucose and glycated haemoglobin with macrovascular complications were examined in Islington, UK [46] and in Hoorn, the Netherlands [47]. In both studies all three measures had similar associations with peripheral vascular disease [46,47]. In Islington however, the 2-h glucose was most strongly associated with major coronary heart disease [46].…”

“…In another study of Pima Indians previously diagnosed by WHO criteria, the three measures of glycaemia were also found to be equivalent as predictors of retinopathy [45]. The relationships of fasting and 2-h plasma glucose and glycated haemoglobin with macrovascular complications were examined in Islington, UK [46] and in Hoorn, the Netherlands [47]. In both studies all three measures had similar associations with peripheral vascular disease [46,47].…”

Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus

“…The associations between FPG and 2-h PG and macrovascular disease have been examined in adults without known diabetes (131). The 2-h PG was somewhat more closely associated with major coronary heart disease, but there was no significant difference in the association of the FPG or the 2-h PG with other indexes of macrovascular disease.…”