A comparison of the sedative and analgesic properties of pethidine (meperidine) and butorphanol in dogs

Vettorato, Enzo; Bacco, S.

doi:10.1111/j.1748-5827.2011.01085.x

Cited by 28 publications

(19 citation statements)

References 42 publications

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“…Peak plasma meloxicam levels are reached in dogs only 2-3 h after SC injection (Leece et al 2005), and this drug has a long half-life of between 10 and 24 h. As described above, meloxicam can adequately control postoperative pain in dogs undergoing surgery for osteoarthritis or laparotomy (for splenectomy or cystotomy) (Mathews et al 2001;Vettorato and Bacco 2011). In the present study, although one of dogs in group M did require rescue analgesia, our data indicate that adequate postoperative analgesia was achieved using meloxicam for 24 h. Previous studies have shown that tolfenamic acid effectively controls postoperative pain for up to 24 h in dogs (Fonda and Perini 2000;Grandemange et al 2007), and our data corroborate this duration of effective analgesia for dogs undergoing ovariohysterectomy.…”

Section: Discussionmentioning

confidence: 99%

“…Current available evidence suggests that meloxicam is safe and efficacious (Cross et al 1997;Mathews et al 2001;Brainard et al 2007). Meloxicam has also been reported to produce adequate analgesia in dogs pre-medicated with acepromazine in combination with pethidine or butorphanol (Vettorato and Bacco 2011), as has been used to control acute postoperative pain in dogs undergoing splenectomy or cystotomy (Mathews et al 2001).…”

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confidence: 99%

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Tolfenamic acid and meloxicam both provide an adequate degree of postoperative analgesia in dogs undergoing ovariohysterectomy

Hu¹,

Luan²,

Guan³

et al. 2017

Vet. Med. - Czech

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This study was aimed at comparing the postoperative analgesic effects of tolfenamic acid and meloxicam in dogs undergoing ovariohysterectomy. Ovariohysterectomy was performed in 24 female dogs. All dogs were administered pre-anaesthetic medication comprised of 0.02 mg/kg i.m. acepromazine, and general anaesthesia was induced with i.v. propofol (4-6 mg/kg) and maintained with 1.5-2.0% isoflurane. Dogs were divided into three groups (n = 8). Following induction of anaesthesia, group C received 0.05 ml/kg sterile saline i.m.; group T received 4 mg/kg tolfenamic acid i.m.; group M received 0.2 mg/kg meloxicam s.c. Heart rate, respiratory rate, rectal temperature, mean arterial pressure and arterial oxygen saturation of haemoglobin were monitored intraoperatively. Pain was assessed using the short form of the Glasgow composite pain scale (SF-GCPS) by two observers who were blinded to the treatment groups; pain was assessed at the time of pre-medication (baseline), and at 2, 4, 6, 8, 12 and 24 h after extubation. Rescue analgesia (0.2 mg/kg i.m. methadone) was administered to any dog with an SF-GCPS score of greater than or equal to six during postoperative monitoring. The pain score in group C was significantly higher compared with group T and group M at 4, 6 and 8 h, while there were no significant differences between the two treatment groups. The mean pain score in group C was also higher than that in group M at 2 h. Rescue analgesia was first administered at 4 h in group C. Rescue analgesia was required by significantly more dogs in group C (n = 8) compared with groups T (n = 0) and M (n = 1), but there was no significant difference between the two treatment groups. Thus, tolfenamic acid and meloxicam provide adequate postoperative analgesia to similar degrees over 24 h in healthy dogs undergoing ovariohysterectomy.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Tolfenamic acid and meloxicam both provide an adequate degree of postoperative analgesia in dogs undergoing ovariohysterectomy

Hu¹,

Luan²,

Guan³

et al. 2017

Vet. Med. - Czech

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“…23 Although the present study did not evaluate MAC, the amount of isoflurane required to maintain anesthesia in both groups (1.0 ± 0.3% and 0.9 ± 0.2% for the methadone and butorphanol groups, respectively) was less than the MAC. [25][26][27][28][29] The present study used a partially validated multidimensional composite scale for assessing postoperative pain in cats undergoing ovariohysterectomy. [2][3][4]13,15,24 In cats, the degree of MAC reduction that occurs with the perioperative use of opioids is a balance between the antinociceptive qualities of opioids, which promote MAC reduction, and the excitatory characteristics of opioids, which oppose MAC reduction and sedation.…”

Section: Discussionmentioning

confidence: 99%

Comparison of perioperative analgesic efficacy between methadone and butorphanol in cats

Warne¹,

Beths²,

Holm³

et al. 2013

javma

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“…Opioides, como a meperidina, e os fenotiazínicos, como a acepromazina, são substâncias amplamente utilizadas na medicina veterinária e possuem poucos efeitos cardiovasculares (Spinosa et al, 2011). Entretanto, a acepromazina pode causar hipotensão e depressão do centro vasomotor (Alvaides et al, 2008;Saponaro et al, 2013;Tranquilli et al, 2014) e a meperidina pode provocar efeito inotrópico negativo (Tranquilli et al, 2014) e cronotrópico positivo (Spinosa et al, 2011;Vettorato e Bacco, 2011).…”

Section: Introductionunclassified

Parâmetros ecocardiográficos em cães saudáveis tratados com acepromazina, meperidina e sua associação

Reis

Aptekmann²,

Egert

et al. 2017

Arq. Bras. Med. Vet. Zootec.

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RESUMO Objetivou-se avaliar os efeitos da tranquilização com meperidina, acepromazina e de sua associação sobre os parâmetros ecocardiográficos em cães. Foram utilizados 12 cães adultos, da raça Rottweiler, submetidos ao exame ecocardiográfico sem utilização de sedação (controle -TC) e a três protocolos de tratamento, utilizando-se meperidina (TM), acepromazina (TA) e a associação dos medicamentos (TMA). As variáveis foram analisadas pelo teste de Tukey (P<0,05). Observou-se que as médias obtidas na onda A do fluxo mitral em TA e TMA diminuíram significativamente com relação ao TM, que não diferiu do TC. Houve uma diminuição significativa no valor de movimento anular mitral (MAM) e excursão sistólica do plano anular tricúspide (ESPAT) no TA. Não houve diferença significativa para os valores de fração de encurtamento (FE) entre TA e os demais tratamentos. Entretanto, observou-se que 57,3% dos cães apresentaram valores de FE abaixo da normalidade. As alterações encontradas podem ser decorrentes dos efeitos hipotensores da acepromazina utilizada de forma isolada. Conclui-se que a meperidina ou sua associação com acepromazina não alteram os parâmetros ecocardiográficos em cães saudáveis e que a acepromazina, utilizada isoladamente, causa alteração nos parâmetros de função sistólica dos cães, não sendo recomendada para a contenção química dos cães submetidos ao ecocardiograma, o que poderia levar à má interpretação do exame. Palavras-chave: cardiologia, tranquilização, neuroleptoanalgesia ABSTRACT The aim of this study was to evaluate the effects of sedation with meperidine, acepromazine and its association on the echocardiographic parameters in dogs. Twelve adult Rottweilers were used and subjected to the echocardiography examination without the use of sedation (control -CT) and subjected to three treatment protocols using meperidine (MT), acepromazine (AT), and the combination of drugs (MAT). Variables were analyzed by Tukey test (p<0,05). The averages obtained in A-wave of mitral inflow in AT and

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A comparison of the sedative and analgesic properties of pethidine (meperidine) and butorphanol in dogs

Abstract: Either butorphanol and pethidine, combined with acepromazine, produced reliable sedation and analgesia up to 4 hours after intramuscular injection in dogs.

Cited by 28 publications

References 42 publications

Tolfenamic acid and meloxicam both provide an adequate degree of postoperative analgesia in dogs undergoing ovariohysterectomy

Tolfenamic acid and meloxicam both provide an adequate degree of postoperative analgesia in dogs undergoing ovariohysterectomy

Comparison of perioperative analgesic efficacy between methadone and butorphanol in cats

Parâmetros ecocardiográficos em cães saudáveis tratados com acepromazina, meperidina e sua associação

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