A comparison of the sedative, hemodynamic, and respiratory effects of dexmedetomidine and propofol in children undergoing magnetic resonance imaging

Abstract

Aim:To compare the sedative, hemodynamic, and respiratory effects of dexmedetomidine and propofol in children undergoing magnetic resonance imaging procedures.Methods:Sixty children between the age of 1 to 7 years were randomly distributed into two groups: The dexmedetomidine (D) group received 1 μg/kg initial dose followed by continuous infusion of 0.5 μg/kg/h, and the propofol group (P) received 3 mg/kg initial dose, followed by a continuous infusion of 100 μg/kg/min. Inadequate sedation was defined as difficulty in completing the procedure because of the child's movement during magnetic resonance imaging. Mean arterial pressure (MAP), heart rate, peripheral oxygen saturation, and respiratory rate (RR) were recorded during the study.Result:The onset of sedation, recovery, and discharge time were significantly shorter in group P than in group D. MAP, heart rate, and RR decreased during sedation from the baseline values in both groups. MAP and RR were significantly lower in group P than in group D during sedation. Dexmedetomidine and propofol provided adequate sedation in most of the children.Conclusion:We conclude that although propofol provided faster anesthetic induction and recovery times, it caused hypotension and desaturation. Dexmedetomidine could be an alternative, reliable sedative drug to propofol in selected patients.

Intraoperative sedation during regional anaesthesia (Caudal epidural anaesthesia) in paediatric patients: Role of intravenous dexemedetomidine

“…1 Since then it has been widely being used in adult population. But there are few studies available which explored its use in paediatric population [1][2][3]5 which have used it for noninvasive procedural like MRI, 2 ICU, 1 EEG 3 ), procedural sedation like Cardiac catheterization, 4 endoscopy, 5 fibreoptic intubation 6 ) and for premedication purpose. 8 Different doses of dexemedetomidine were studied.…”

“…1 Dexemedetomidine is widely used for sedation in adult population, but in paediatric patients such data are sparse. However, the studies [1][2][3][4] have evaluated the sedative property of dexemedetomidine in children for sedation in the ICU, 1 invasive and noninvasive procedures such as MRI, 2 EEG, 3 nuclear medicine studies, cardiac catheterization, 4 endoscopy, 5 fibreoptic intubation 6 etc. But they all studied it for procedural sedation.…”

Procedural sedation in children and adolescents: recommendations based on grade system

“…As evidências são insuficientes para recomendar um medicamento em superioridade a outro (2C). [18][19][20][21][22][23][24] Por isso, a escolha do sedativo deve ser feita caso a caso, prevendo eventos adversos associados a cada droga e de acordo com estado clínico basal, comorbidades de cada paciente e experiência do médico.…”

Caveat lector

“…[1] The article described a study performed by Drs. Jaydev Dave and Sandip Vaghela, from the MP Shah Medical College, in Jamnagar, India, assessing the effects of dexmedetomidine and propofol in children undergoing magnetic resonance imaging (MRI) scanning.…”

“…On January 13, 2012, it came to the attention of the Editorial Board of the Saudi Journal of Anesthesia that the journal had published a fraudulent manuscript. [ 1 ] The article described a study performed by Drs. Jaydev Dave and Sandip Vaghela, from the MP Shah Medical College, in Jamnagar, India, assessing the effects of dexmedetomidine and propofol in children undergoing magnetic resonance imaging (MRI) scanning.…”