A comparison of the wound healing process after the application of three dermal substitutes with or without basic fibroblast growth factor impregnation in diabetic mice

Notodihardjo, Sharon Claudia; Morimoto, Naoki; Munisso, Maria Chiara; Le, Tien Minh; Mitsui, Toshihito; Kakudo, Natsuko; Kusumoto, Kenji

doi:10.1016/j.bjps.2020.01.031

Cited by 28 publications

(21 citation statements)

References 24 publications

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“…Since, a one-step skin grafting and a split-thickness skin graft approach to cover the wound at the same time is desirable, numerous bi-layer skin substitutes have been developed for the management of full-thickness skin defects, such as Alloderm ® [ 19 , 20 ], Integra ® [ 21 ], Pelnac ® [ 22 ], and Matriderm ® [ 23 , 24 ]. These commercial matrices are all produced with collagen of bovine, porcine, and equine origin.…”

Section: Introductionmentioning

confidence: 99%

A Prototype Skin Substitute, Made of Recycled Marine Collagen, Improves the Skin Regeneration of Sheep

Melotti

Martinello

Perazzi

et al. 2021

Animals

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Skin wound healing is a complex and dynamic process that aims to restore lesioned tissues. Collagen-based skin substitutes are a promising treatment to promote wound healing by mimicking the native skin structure. Recently, collagen from marine organisms has gained interest as a source for producing biomaterials for skin regenerative strategies. This preliminary study aimed to describe the application of a collagen-based skin-like scaffold (CBSS), manufactured with collagen extracted from sea urchin food waste, to treat experimental skin wounds in a large animal. The wound-healing process was assessed over different time points by the means of clinical, histopathological, and molecular analysis. The CBSS treatment improved wound re-epithelialization along with cell proliferation, gene expression of growth factors (VEGF-A), and development of skin adnexa throughout the healing process. Furthermore, it regulated the gene expression of collagen type I and III, thus enhancing the maturation of the granulation tissue into a mature dermis without any signs of scarring as observed in untreated wounds. The observed results (reduced inflammation, better re-epithelialization, proper development of mature dermis and skin adnexa) suggest that sea urchin-derived CBSS is a promising biomaterial for skin wound healing in a “blue biotechnologies” perspective for animals of Veterinary interest.

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Section: Introductionmentioning

confidence: 99%

A Prototype Skin Substitute, Made of Recycled Marine Collagen, Improves the Skin Regeneration of Sheep

Melotti

Martinello

Perazzi

et al. 2021

Animals

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“… 9 Moreover, an in vivo study showed that Pelnac Gplus impregnated with bFGF accelerates capillary formation, granulation tissue formation, and epithelialization. 10 We hypothesize that combination with negative pressure wound therapy could obtain even faster tissue granulation.…”

Section: Discussionmentioning

confidence: 99%

Less-invasive Treatment for Group A Streptococcal Fasciitis with Rapid Antigen Detection Test and Collagen/Gelatin Sponge

Tsuge

Matsui

Takeda

et al. 2021

Plastic and Reconstructive Surgery - Global Open

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Summary: Patients with severe group A Streptococcus (GAS) induced necrotizing soft tissue infection sometimes develop Streptococcal toxic shock syndrome, which is a life-threatening condition with an extremely high fatality rate. Obtaining survival is the most important goal; however, an early diagnosis for debridement surgery and quick granulation formation for skin grafting surgery can better preserve the extremity functions. The patient was a 47-year-old man with a history of atopic dermatitis who presented with GAS-induced necrotizing soft tissue infection in his left lower extremity. His vital signs indicated shock, and he was diagnosed with streptococcal toxic shock syndrome. Emergency surgery was performed with his body pressure maintained with noradrenaline. Intraoperatively, rapid antigen detection tests (RADTs) were negative in the medial thigh and positive in the lower leg, which helped in decision-making regarding the area of aggressive debridement surgery. The wound culture results matched the intraoperative rapid antigen detection test results. A collagen/gelatin sponge with the sustained release of basic fibroblast growth factor was used as an artificial dermis before skin grafting. Excellent granulation was obtained, and skin grafting surgery was performed on the 11th day after collagen/gelatin sponge placement. He was discharged home on the 42nd day with normal lower extremity functions. First, an intraoperative diagnosis using GAS-rapid antigen detection tests with an appropriate sampling method from small incisions avoided excessive surgical debridement. Second, collagen/gelatin sponge with the sustained release of basic fibroblast growth factor promoted quick granulation tissue formation for wound bed preparation. These efforts resulted in the successful less-invasive treatment of a patient with streptococcal toxic shock syndrome caused by GAS-induced necrotizing soft tissue infection.

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“…Integra® Dermal Regeneration Template (Integra Life Sciences Corporation, Plainsboro, New Jersey, US) was the first dermal skin substitute product approved by the US Food and Drug Administration (FDA). It consists of a porous matrix of cross-linked bovine tendon collagen type I, shark chondroitin-6-sulfate GAG and covered by a semi-permeable silicone membrane [47,[49][50][51][52][53]. Chondroitin-6-sulfate GAG has been shown to have antiinflammatory effect on macrophages; however, when the effects of Integra® on macrophage phenotype was analysed, a temporal down-regulation of 'M2a' macrophages (ECM deposition macrophages) was observed [54,55].…”

Section: Skin Substitutesmentioning

confidence: 99%

Wound dressings: curbing inflammation in chronic wound healing

Verdolino

Thomason

Fotticchia

et al. 2021

Emerging Topics in Life Sciences

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Chronic wounds represent an economic burden to healthcare systems worldwide and a societal burden to patients, deeply impacting their quality of life. The incidence of recalcitrant wounds has been steadily increasing since the population more susceptible, the elderly and diabetic, are rapidly growing. Chronic wounds are characterised by a delayed wound healing process that takes longer to heal under standard of care than acute (i.e. healthy) wounds. Two of the most common problems associated with chronic wounds are inflammation and infection, with the latter usually exacerbating the former. With this in mind, researchers and wound care companies have developed and marketed a wide variety of wound dressings presenting different compositions but all aimed at promoting healing. This makes it harder for physicians to choose the correct therapy, especially given a lack of public quantitative data to support the manufacturers’ claims. This review aims at giving a brief introduction to the clinical need for chronic wound dressings, focusing on inflammation and evaluating how bio-derived and synthetic dressings may control excess inflammation and promote healing.

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A comparison of the wound healing process after the application of three dermal substitutes with or without basic fibroblast growth factor impregnation in diabetic mice

Cited by 28 publications

References 24 publications

A Prototype Skin Substitute, Made of Recycled Marine Collagen, Improves the Skin Regeneration of Sheep

A Prototype Skin Substitute, Made of Recycled Marine Collagen, Improves the Skin Regeneration of Sheep

Less-invasive Treatment for Group A Streptococcal Fasciitis with Rapid Antigen Detection Test and Collagen/Gelatin Sponge

Wound dressings: curbing inflammation in chronic wound healing

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