A comparison of three histological grading systems in endometrial cancer

Abstract

Grades of the tumors often change when different grading systems are used. Postoperative treatment should be considered when at least one of the grading systems indicates poor differentiation.

Impact of histological grade on oncologic outcomes in clinical stage I patients with endometrial carcinoma patients after definitive primary radiation therapy

“…It is important to note that National Cancer Database histological grading reported in this study is based on nuclear grade and not FIGO grade. Studies on association between nuclear grade and FIGO grade have been mixed, with up to 80% concordance in one study20 and no statistical correlation in another 21. However, patient outcomes, such as progression-free survival and overall survival are similar between FIGO grade and nuclear grade 20 22.…”

ORIGINAL ARTICLE: Medical and surgical management of reproductive neoplasia in two western lowland gorillas (Gorilla gorilla gorilla)

“…These include architectural grading, based on the proportion of glandular and solid portions of the tumor, nuclear grading, based on nuclear morphology, and a combination of these two systems. The latter was adopted by FIGO in 1988 [4]. The FIGO grading system was utilized in this case.…”

“…Grade 2 adenocarcinoma has solid areas occupying 5–50% of the lesion, irregular oval nuclei, chromatin clumping, and moderate sized nucleoli. Grade 3 adenocarcinoma has solid areas >50% of the lesion, large pleomorphic nuclei, coarse chromatin, and large irregular nucleoli [4]. Five‐year survival rates in women with grade 1, 2, and 3 tumors according to the FIGO grading system were 96%, 91.7%, and 81%, respectively [4].…”

“…Invasiveness could not be assessed because the biopsy did not contain any adjacent tissue. An initial diagnosis of endometrial adenocarcinoma Grade 2 was made based on the International Federation of Gynecology and Obstetrics (FIGO) grading scheme [4], which incorporates both the overall architecture of the mass and the nuclear morphology.…”