A comparison of tissue-engineered bone from adipose-derived stem cell with autogenous bone repair in maxillary alveolar cleft model in dogs

Pourebrahim, Nematollah; Hashemibeni, Batool; Shahnaseri, Shirin; Torabinia, Nakisa; Mousavi, B.; Adibi, Sadaf; Heidari, Fariba; Alavi, Mousa

doi:10.1016/j.ijom.2012.10.012

Cited by 69 publications

(75 citation statements)

References 21 publications

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“…A study showed that after a 3 month healing period, the addition of ASCs to plateletrich plasma (PRP) enhanced the amount of n-ewly formed dog alveolar bone [67], and other studies came to thesimilar conclusions [68,69]. One study compared the use of ASCs and autogenous bone grafts in dogs, bone formation in the maxillary alveolar cleft was higher in the autograft group [70]. More long-term experiments examining the safety of ASCs transplantation in appropriate animal models are required before advanced studies in patients.…”

Section: Latest Results and Achievementsmentioning

confidence: 99%

Perspectives on regeneration of alveolar bone defects

et al. 2013

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Section: Latest Results and Achievementsmentioning

confidence: 99%

Perspectives on regeneration of alveolar bone defects

et al. 2013

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“…In another study, autografts and tissue-engineered bone were used for bone regeneration. Bone formation on the autograft sides was higher than on the stem cell sides, demonstrating that autograft is still the gold standard for bone regeneration and tissue engineered bone may provide an acceptable alternative [132].…”

Section: Cleft Palatementioning

confidence: 95%

“…4 studies reported success of alveolar defect repair using DPSC [132], BMSC/PRF [130], Adipose derived stem cells [131] and mesenchymal stem cells derived from iliac bone [133].…”

Section: Cleft Palatementioning

confidence: 99%

The Current Status of Stem Cell Regeneration in Intra Oral Applications—A Systematic Review

Kanwal¹,

D’souza²,

Muthiah³

et al. 2017

OJST

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Aim: 1) To review the literature of various applications of stem cell regeneration in dentistry from 2010 to 2016. 2) To review these studies and to summarize the current status of stem cell regeneration in intra oral applications.3) To present the available successful data with regard to stem cell regeneration in dentistry and to highlight the future trends. Materials and Methods: Search Protocol: A systematic search was made in the PubMed database with the key words gingiva, papillary reconstruction, periodontal ligament, dental pulp, salivary gland, enamel re-mineralization, dentin, cementum, bone, whole tooth, cleft palate, regeneration and stem cells. All articles from 2010 to 2016, relevant to the topic were included. After the search a total of 1826 articles were obtained which were screened and categorized by three independent reviewers as review papers, in vitro, animal and human studies, pertaining to stem cell regeneration in intra oral applications. On the basis of the extracted data and outcome measures, conclusions were drawn. Results: Maximum number of animal studies has been done to regenerate periodontal tissues, bone, dentin and pulp tissues. Few human studies have been done till date. Although clinically, researchers have been able to regenerate periodontal-like tissue, bone and pulp-like tissue, they still haven't been able to regenerate tissues that completely resemble tissues in their natural form. Conclusion: The future of stem cell therapy in dental applications looks promising. The predictability and efficacy of outcomes, as well as safety concerns of stem cell therapy is yet to be fully established. Ongoing research and development of newer scaffolds, understanding various signaling molecules and their cues, understanding gene expression and proteomics of stem cells are the future directions that will take us a step forward to achieving successful regeneration.

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“…Currently, autogenous mesenchymal stem cells (MSCs) are regarded as the optimum choice for in vivo osteogenic reconstructions; these can come from umbilical cord blood, Wharton's jelly, and even the patient's own bone marrow [26]. Tissue regenerative-specific repair of CL/P has been demonstrated with some success, and some are now advocating for in depth considering of its potential to replace traditional autogenous grafting procedures [27].…”

Section: The Future Of Cl/p Therapymentioning

confidence: 99%

A Review of Orofacial Clefting and Current Genetic Mouse Models

Keteyian¹,

Mishina²

2017

Designing Strategies for Cleft Lip and Palate Care

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The prevalence of orofacial clefts (OFCs) is nearly 10.2 per 10,000 births in the United States and 9.9 per 10,000 births worldwide. OFCs occur as a result of a break (nonfusion) of orofacial structures during development. This can occur due to a variety of reasons;prenatal exposure to many drugs and environmental factors as well as genetic factors which are implicated in the development of OFCs. While approximately 15 types of clefts have been identified, there are at least four distinct classifications of OFCs. These include complete cleft palate with cleft lip; cleft of the anterior palate, which may/may not involve cleft lip; cleft of the posterior palate; and submucosal cleft. A number of candidate genes have been identified, including transforming growth factor beta (TGFβ) and homeobox genes (e.g., MSX1), among many others. What follows is a review of mouse models currently used in research and the classification of their overall contribution to known OFCs.

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A comparison of tissue-engineered bone from adipose-derived stem cell with autogenous bone repair in maxillary alveolar cleft model in dogs

Cited by 69 publications

References 21 publications

Perspectives on regeneration of alveolar bone defects

Perspectives on regeneration of alveolar bone defects

The Current Status of Stem Cell Regeneration in Intra Oral Applications—A Systematic Review

A Review of Orofacial Clefting and Current Genetic Mouse Models

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