A comparison of tumour size measurements with palpation, ultrasound and mammography in male breast cancer: first results of the prospective register study

Streng, Martin; Ignatov, Atanas; Reinisch, Mattea; Costa, Serban-Dan; Eggemann, Holm

doi:10.1007/s00432-017-2554-8

Cited by 5 publications

(2 citation statements)

References 26 publications

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“…The last update was in May 2020. Other studies conducted on the basis of this database have already been published [ 7 , 21 , 22 ]. Formalin-fixed, paraffin-embedded tumour samples from 161 patients were available for this retrospective analysis.…”

Section: Methodsmentioning

confidence: 99%

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The impact of G protein-coupled oestrogen receptor 1 on male breast cancer: a retrospective analysis

Maiwald¹,

Sprung²,

Czapiewski³

et al. 2021

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Introduction: The G protein-coupled oestrogen receptor 1 (GPER-1) is a potential prognostic marker in breast cancer. However, its role in male breast cancer (MBC) is still unknown. This study evaluates the expression of GPER-1 in MBC samples and correlates these data with clinical and pathological parameters including patients' survival. Material and methods: For this retrospective analysis of a prospectively maintained cohort of patients with MBC, we examined 161 specimens for GPER-1 expression using immunohistochemistry. An immunoreactive score (IRS) was calculated based on staining intensity and the percentage of positive tumour cells. Then, we correlated GPER-1 IRS with clinical and pathological parameters, and overall and relapse-free survival. Results: About 40% of MBC samples were positive for GPER-1 expression (IRS ≥ 4). There was no significant correlation with clinicopathological parameters, such as hormone receptor status or grading. However, a statistical trend was observed for tumour size (≥ 2 cm, p = 0.093). Kaplan-Meier survival analysis revealed no significant correlation with relapse-free survival. However, there was a significant correlation with overall survival, but when we adjusted the log-rank p-value to compensate for the cut-off point optimization method, it rose above 0.1. Additionally, GPER-1-positive patients were older at diagnosis. When adjusted for age by multivariable Cox regression analysis, the significance of GPER-1 status for survival was further reduced. Conclusions: We found no significant prognostic value of GPER-1 in this MBC cohort as anticipated from studies on female BC. Future studies with higher sample size are needed to further verify a potential sex-specific role of GPER-1.

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Section: Methodsmentioning

confidence: 99%

“…More than 90% of MBC cases are oestrogen receptor (ER)-positive, and 80-90% progesterone receptor (PR)-positive. Compared to female breast cancer (FBC), these frequencies are higher [5][6][7]. HER-2/neu is expressed in 5-29% of MBC cases compared to 15-25% in FBC cases [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

The impact of G protein-coupled oestrogen receptor 1 on male breast cancer: a retrospective analysis

Maiwald¹,

Sprung²,

Czapiewski³

et al. 2021

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Patterns of Discordance Between Clinical and Pathologic Stage in Head and Neck Cancer

Hondorp,

Punjabi,

Macias

et al. 2024

The Laryngoscope

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ObjectiveTo enhance understanding in patterns of discordance between clinical and pathological T and N staging in multiple sites of head and neck squamous cell cancer.MethodsA retrospective cohort of 580 newly diagnosed and surgically treated head and neck squamous cell carcinoma patients from a single institution over a 10‐year period are presented. Clinical and pathologic staging are compared.ResultsNotably, 33% of cases had staging discordance. Overall Cohen's kappa agreement was κ = 0.55 (moderate agreement). Highly discordant site stages with κ < 0.45 included: T2 oral cavity, T2 oropharynx, T3 larynx, and N1 lymph node. T2‐4 oral cavity cancers were often overstaged, and more than one‐third of T3 larynx cancers were understaged. Highly concordant site stages with κ>0.65 included: T1 larynx, T4 oropharynx, N0 lymph node, and N3 lymph node.ConclusionThere exists a quantifiable and, in certain sites, clinically relevant pattern of discordance between clinical and pathologic staging. Tumor board multidisciplinary evaluation can highlight these discrepancies and aide in limiting effects on treatment decisions. However, discordant staging can affect the interpretation and application of prognostication, treatment, and data accuracy. Further investigation is warranted to improve clinical staging accuracy in areas of highest discordance.Level of Evidence3 Laryngoscope, 2024

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Prediction of tumor size in patients with invasive ductal carcinoma using FT-IR spectroscopy combined with chemometrics: a preliminary study

et al. 2021

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A comparison of tumour size measurements with palpation, ultrasound and mammography in male breast cancer: first results of the prospective register study

Cited by 5 publications

References 26 publications

The impact of G protein-coupled oestrogen receptor 1 on male breast cancer: a retrospective analysis

The impact of G protein-coupled oestrogen receptor 1 on male breast cancer: a retrospective analysis

Patterns of Discordance Between Clinical and Pathologic Stage in Head and Neck Cancer

Prediction of tumor size in patients with invasive ductal carcinoma using FT-IR spectroscopy combined with chemometrics: a preliminary study

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