2004
DOI: 10.1016/j.accreview.2003.10.048
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A comparison of two invasive strategies in patients with non-st elevation acute coronary syndromes: results of the early or late intervention in unStable angina (ELISA) pilot study: 2b/3a upstream therapy and acute coronary syndromes

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Cited by 9 publications
(15 citation statements)
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“…This result was supported by many studies which consistently reported better outcomes with upstream or early use of glycoprotein IIb/IIIa inhibitor compared with deferred treatment or other strategies (LOE 1 [452][453][454][455][456][457][458][459][460][461][462][463][464][465][466][467] ; LOE 2 468 -473 ; LOE 3 474 ; LOE 4 [475][476][477][478] ; LOE 5 479 ).…”
Section: Consensus On Sciencesupporting
confidence: 60%
“…This result was supported by many studies which consistently reported better outcomes with upstream or early use of glycoprotein IIb/IIIa inhibitor compared with deferred treatment or other strategies (LOE 1 [452][453][454][455][456][457][458][459][460][461][462][463][464][465][466][467] ; LOE 2 468 -473 ; LOE 3 474 ; LOE 4 [475][476][477][478] ; LOE 5 479 ).…”
Section: Consensus On Sciencesupporting
confidence: 60%
“…Moreover, in the Can Rapid Risk Stratification of Unstable Angina Patients Suppress Adverse Outcomes with Early Implementation of the ACC/AHA Guidelines (CRUSADE) registry, 11 very early intervention was associated with a trend toward a survival benefit. Finally, in a recent multicenter trial, 12 an early (≤24 hours) invasive strategy in NSTEMI patients showed advantage over a delayed invasive 13 only 8% of the patients in the early group has been treated with GP IIb/IIIa inhibitors, and in the ABOARD trial, 14 most of the patients in the deferred intervention were treated very early (≤24 hours from admission). The benefit of a fast invasive treatment may be linked to the high prevalence of basal impaired myocardial perfusion in NSTEMI patients, even with upstream use of GP IIb/IIIa inhibitors.…”
Section: Discussionmentioning
confidence: 99%
“…Both trials randomized patients to routine upstream therapy with tirofiban or selective downstream therapy. The design of ELISA-1 and ELISA-2 differed only with regard to the timing of angiography and the upstream use of clopidogrel [4,5].…”
Section: Methodsmentioning
confidence: 99%
“…In-and exclusion criteria have been described and were the same for both studies [4,5]. In brief, patients with symptoms of chest pain lasting more than 30 min in the previous 24 h before admission and either or both ST segment depression (1 mm or more) or a positive cardiac biomarkers (troponin T or CKMB) were included.…”
Section: Methodsmentioning
confidence: 99%
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