This paper focuses on sustainable mobility city planning as a process that innovates and develops cities.The indications laid down by the European Union (UE) urge us to review urban spaces in order to transform degraded areas into smart areas and, therefore, restart a process of rebalancing and sustainability, with the goal of transforming cities into smart cities. The planning activity supports the social, economic, and technological change processes. The regeneration of disused areas creates opportunities for sustainable growth. This paper presents the issue of urban regeneration. A project of an urban distribution center, in a city logistics system, is designed for a disused railway area, located near the harbour in Reggio Calabria. The case study has tested the application of a model of urban regeneration, through the design of innovation zones, according to European Union strategies to encourage the development of a smart city.