A Comparison of VerifyNow® with PlateletMapping® -Detected Aspirin Resistance and Correlation with Urinary Thromboxane

Carroll, Roger C.; Craft, Robert M.; Snider, Carolyn C.; Aligeti, Venkata R.; Wortham, Dale C.

doi:10.1213/ane.0b013e318277de06

Cited by 8 publications

(4 citation statements)

References 19 publications

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“…This finding of normal platelet function and lack of inhibition by TEG-PM testing raises two pertinent questions regarding (1) the sensitivity and ability of TEG-PM to evaluate platelet inhibition in the setting of ASA and (2) the ability of ASA to provide lasting platelet inhibition in children requiring prophylaxis prior to surgery. The TEG-PM has been shown to demonstrate good correlation with urinary thromboxane B2 levels 11,38 and with light transmittance platelet aggregation (LTA). 11,39 The LTA 40 and urinary 11dehydrothromboxane B2 levels 41 are considered to be the two standards in the evaluation of ASA responsiveness via the AA pathway.…”

Section: Discussionmentioning

confidence: 99%

Antiplatelet Effect of Ketorolac in Children After Congenital Cardiac Surgery

Kim

Kaufman

Patel

et al. 2018

World J Pediatr Congenit Heart Surg

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Background: Ketorolac is used for pediatric analgesia after surgery despite its known platelet inhibition via the arachidonic acid (AA) pathway. The degree of platelet inhibitory effect after cardiac surgery is not well characterized. Thromboelastography with platelet mapping (TEG-PM) is emerging as a frequently used test to evaluate platelet inhibition via the AA pathway. Methods: Post hoc analysis of a data set collected in a prospective observational cohort study evaluating platelet inhibition in children after congenital heart surgery with cardiopulmonary bypass (CPB). Categorization into two groups: (1) received ketorolac and (2) did not receive ketorolac for analgesia after surgery. The TEG-PM was evaluated at two time points (prior to surgery and 12-48 hours after CPB). Results: Fifty-three children were studied; mean age was 6.6 (range: 0.07-16.7) years and 45% (n ¼ 24) were female. Participants were distributed into two groups by ketorolac use, 41 within the ketorolac group and 12 in the no ketorolac group. All 41 participants who received ketorolac had platelet inhibition and 11 (91.7%) of 12 participants who did not receive ketorolac had normal platelet function after surgery (P < .0001). There was no difference in patient characteristics or clinical data between the two groups. Conclusions: Ketorolac use in a cohort of children after congenital cardiac surgery was associated with platelet inhibition via the AA pathway when evaluated by TEG-PM.

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Section: Discussionmentioning

confidence: 99%

Antiplatelet Effect of Ketorolac in Children After Congenital Cardiac Surgery

Kim

Kaufman

Patel

et al. 2018

World J Pediatr Congenit Heart Surg

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“…The TEG offers an assay called PlateletMapping®, FDA-cleared, that uses maximum amplitude to detect ALR and CLR. 22 ROTEM assays for ALR and CLR await FDA clearance. Diagnostica Stago, Inc, offers the research use only intracellular vasodilator-stimulated phosphoprotein (VASP) phosphorylation enzyme immunoassay, Cy -Quant VASP/P2Y12.…”

Section: Platelet Function Testingmentioning

confidence: 99%

Managing Antiplatelet Therapy

Fritsma¹

2015

Clin Lab Sci

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“…PM shows good sensitivity for detecting aspirin resistance and has been used to demonstrate that reversal of platelet inhibition by aspirin or clopidogrel (Plavix) begins about 3 days after stoppage [Carroll et al., ; Cattano et al., ]. Mahla et al.…”

Section: Teg®/platelet Mappingmentioning

confidence: 99%

“…Verify Now has agonists to examine the antiplatelet activity of GPIIb/IIIa inhibitors, ASA, and clopidogrel, and is able to report and quantify the degree of platelet inhibition with good correlation to laboratory‐based LTA [Malinin et al., ; Gremmel et al., ; Grove et al., ]. The system may be less sensitive than Platelet Mapping for assessment of aspirin resistance [Carroll et al., ].…”

Section: Verify Nowmentioning

confidence: 99%

Point of Care Testing in Cardiac Surgery: Diagnostic Modalities to Assess Coagulation and Platelet Function

Stafford

Weitzel

2013

Drug Development Research

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Point of Care testing in the perioperative arena is a high priority topic, specifically in cardiac surgery where a majority of perioperative blood transfusions occur. Platelet function in particular is of interest in cardiac surgery as cardiopulmonary bypass itself creates known platelet dysfunction, but also because more and more patients are on antiplatelet agents due to coronary stenting procedures. This review will focus on presenting current data relating to platelet function in the perioperative setting, along with a brief review of general coagulation concepts. Drug Dev Res 74 : 418-427, 2013.

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A Comparison of VerifyNow® with PlateletMapping® -Detected Aspirin Resistance and Correlation with Urinary Thromboxane

Abstract: These results indicate that PlateletMapping could be a useful point-of-care assay to identify aspirin-resistant patients for better perioperative risk stratification and management.

Cited by 8 publications

References 19 publications

Antiplatelet Effect of Ketorolac in Children After Congenital Cardiac Surgery

Antiplatelet Effect of Ketorolac in Children After Congenital Cardiac Surgery

Managing Antiplatelet Therapy

Point of Care Testing in Cardiac Surgery: Diagnostic Modalities to Assess Coagulation and Platelet Function

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