A comparison of vertical versus transverse sections in the evaluation of alopecia biopsy specimens

Elston, Dirk M.; Ferringer, Tammie; Dalton, Scott R.; Fillman, Eric P.; Tyler, William

doi:10.1016/j.jaad.2005.03.007

Cited by 63 publications

(73 citation statements)

References 16 publications

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“…LPP'nin kesin tanısı histopatolojik inceleme ile konur [3][4][5][6] . Skalp biyopsi örneklerinin değerlendirmesinde kullanılan transvers ve vertikal kesitlerin tanısal açıdan farklı üstünlükleri vardır 22,23 . Transvers kesitlerde follikül yoğunluğu, folliküler ünite morfolojisi, iç kök kılıfı deskuamasyonu ve anagen/katagen-telogen evredeki terminal folliküllerin oranı daha doğru olarak değerlendirilebilir 24 .…”

Section: Introductionunclassified

“…Transvers kesitlerde follikül yoğunluğu, folliküler ünite morfolojisi, iç kök kılıfı deskuamasyonu ve anagen/katagen-telogen evredeki terminal folliküllerin oranı daha doğru olarak değerlendirilebilir 24 . Vertikal kesitlerde ise dermoepidermal bileşke, papiller dermis ve subkütan dokudaki değişiklikler saptanabilir 23,24 . Bu nedenle, tüm alopesi tiplerinde olduğu gibi LPP'de de tanısal değeri artırmak amacıyla 2 biyopsi alınarak her iki yöntemin birlikte kullanılması önerilmektedir 22 .…”

Section: Introductionunclassified

“…Bu nedenle, tüm alopesi tiplerinde olduğu gibi LPP'de de tanısal değeri artırmak amacıyla 2 biyopsi alınarak her iki yöntemin birlikte kullanılması önerilmektedir 22 . Tek biyopsi alınabilen durumlarda ise, klinik olarak LPP düşünülen hastalarda transvers kesitlerden daha üstün olduğu bulunduğu için vertikal kesitlerin tercih edilmesi önerilmiştir 23,24 . Bizim çalışmamızda tüm hastalardan 2 adet biyopsi örneği alınmış, transvers ve vertikal kesitlerdeki histopatolojik bulgular birlikte incelenerek kesin tanı konmuştu.…”

Section: Introductionunclassified

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Lichen planopilaris: Demographic, clinical and histopathological characteristics and treatment outcomes of 25 cases

Özcan¹,

Seckın²,

Güleç³

et al. 2015

TURKDERM

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Background and Design: Lichen planopilaris (LPP) is a type of cicatricial alopecia characterized by autoreactive lymphocytic destruction of the hair follicle. We aimed to evaluate the demographic, clinical and histopathological features, and treatment outcomes of patients with LPP. Materials and Methods: Medical reports of 25 patients, who have been diagnosed with LPP according to the clinical and histopathological findings between January 2006 and June 2012, were retrospectively reviewed. The transverse and vertical sections of scalp biopsy specimens were re-evaluated by a pathologist, and the findings were noted. Results: Of the 25 patients, 18 were female and 7 were male, the mean age was 49.8±12.4 years. Eighteen patients had been diagnosed with classic LPP and 7 patients with frontal fibrosing alopecia (FFA). The alopecia has begun in postmenopausal period in 5 patients with FFA. Alopecia was associated with pruritus, pain and/or burning in 19 patients. Extra-scalp involvement was observed in 11 patients. The most common clinical findings were follicular hyperkeratosis (92%), perifollicular erythema (48%), perifollicular lichenoid papules, and positive hair-pull test (44%). Dermatoscopic examination was performed in 14 patients, and most commonly, absence of follicular openings (100%), perifollicular scales (92.9%) and perifollicular erythema (50%) were noted. The most common diagnostic histopathological findings were follicular vacuolar and lichenoid degeneration (88%) and vacuolar and lichenoid interface changes (56%). Twenty-three patients who were started on treatment received topical, intramuscular and intralesional corticosteroids, topical minoxidil, oral tetracycline, cyclosporine A, and hydroxychloroquine either alone or in combination. Progression of alopecia was prevented and the symptoms and/or signs were reduced in 12 (75%) of 16 patients whose follow-up data were available. Conclusion: LPP can be diagnosed accurately through a detailed clinical examination, dermatoscopy and histopathological examination. The symptoms and/or signs can be reduced and progression of the disease can be prevented with treatment.

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Section: Introductionunclassified

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Lichen planopilaris: Demographic, clinical and histopathological characteristics and treatment outcomes of 25 cases

Özcan¹,

Seckın²,

Güleç³

et al. 2015

TURKDERM

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“…17 Vertical sections have the advantage of providing visualization of the overall reaction pattern and of the superficial dermis and dermoepidermal junction. Vertical sections are used at our institution for technical reasons and because of the preferences of our dermatopathologists.…”

Section: Introductionmentioning

confidence: 99%

A histologic review of 27 patients with lichen planopilaris

Tandon

Somani

Cevasco

et al. 2008

Journal of the American Academy of Dermatology

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“…Symptoms, inflammatory stigmata, and a positive pull test are helpful signs. Transverse sectioning of the biopsy specimen is conventionally advocated to ensure that all follicles are assessed at multiple planes; however, loss of critical diagnostic features in the epidermis, superficial dermis, and panniculus with this mode can impair interpretation [49,69]. Obtaining a second specimen for vertical sectioning can improve diagnostic yield, but may still not allow distinction among predominantly lymphocytic or neutrophilic inflammation [48,111].…”

Section: Approach To the Patient With Cicatricial Alopeciamentioning

confidence: 99%

Primary Cicatricial Alopecia

Ross¹,

Shapiro²

Hair Growth and Disorders

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A comparison of vertical versus transverse sections in the evaluation of alopecia biopsy specimens

Cited by 63 publications

References 16 publications

Lichen planopilaris: Demographic, clinical and histopathological characteristics and treatment outcomes of 25 cases

Lichen planopilaris: Demographic, clinical and histopathological characteristics and treatment outcomes of 25 cases

A histologic review of 27 patients with lichen planopilaris

Primary Cicatricial Alopecia

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