2015
DOI: 10.4314/sokjvs.v12i3.4
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A Comparison of xylazine/ketamine, diazepam/ketamine and acepromazine/ketamine anaesthesia in Rabbit

Abstract: The efficacy and safety of the recommended intramuscular (im) clinical doses of xylazine-ketamine (5mg-35mg/kg), diazepam-ketamine (5mg-60mg/kg) and acepromazine-ketamine (5mg-75mg/kg) post administration were obtained, evaluated and compared using the following parameters in 10 apparently healthy rabbits: vital parameters (means of heart rates, respiratory rates and temperature), onset of loss of righting reflex, onset of analgesia, duration of analgesia, duration at recumbency and attempts to stand. Onset of… Show more

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Cited by 18 publications
(12 citation statements)
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“…Elevation of serum lipid profile has been noted in these groups after 12 weeks of cholesterol addition to diets and level of HDL decreased significantly, similar to the result by Oguntoye. 12 Furthermore, a strong relationship between using of irbesartan treatment and decreasing of total cholesterol, TG, LDL, VLDL with little effect on HDL-C, where similar results have been found by Zhao et al 13 and Del Fiorentino et al 6 This could be ascribed to direct effect of peroxisome proliferation activated receptor alpha, this receptor regulates gene expression that is responsible for fatty acid oxidation. 16 The renin-angiotensin-aldosterone system has been demonstrated to play not only an important role in cardiovascular homeostasis by influencing vascular tone and fluid-electrolyte balance, but has also been involved in the atherothrombotic process, cardiac remodeling and apoptosis.…”
Section: Discussionsupporting
confidence: 56%
See 1 more Smart Citation
“…Elevation of serum lipid profile has been noted in these groups after 12 weeks of cholesterol addition to diets and level of HDL decreased significantly, similar to the result by Oguntoye. 12 Furthermore, a strong relationship between using of irbesartan treatment and decreasing of total cholesterol, TG, LDL, VLDL with little effect on HDL-C, where similar results have been found by Zhao et al 13 and Del Fiorentino et al 6 This could be ascribed to direct effect of peroxisome proliferation activated receptor alpha, this receptor regulates gene expression that is responsible for fatty acid oxidation. 16 The renin-angiotensin-aldosterone system has been demonstrated to play not only an important role in cardiovascular homeostasis by influencing vascular tone and fluid-electrolyte balance, but has also been involved in the atherothrombotic process, cardiac remodeling and apoptosis.…”
Section: Discussionsupporting
confidence: 56%
“…Cholesterol and saturated fatty acid are the main contributing factor in exacerbation of atherosclerosis by building up of cholesterol in the wall of artery leading to narrowing down artery walls and this stricture limits oxygen supply to the site of organ especially heart. 12,13 Fig. 3 Photomicrograph of histomorphometric section of aortic arch of rabbit (group I) normal control group that show intact endothelium with normal intimal thickness.…”
Section: Discussionmentioning
confidence: 99%
“…After six (6) weeks of chitosan-supplemented diets feeding, all the rats were weighed and sacrificed after an overnight fast. The animals were anaesthetized using ketamine [(35 mg/kg)/ xylazine (5 mg/kg)] [ 24 ]. The liver and kidney were excised thereafter, washed in cold physiological saline, and frozen until needed for analyses.…”
Section: Methodsmentioning
confidence: 99%
“…In the next day, anesthesia was induced in rabbits using xylazine and ketamine as method described by Oguntoye et al [ 48 ]. Briefly, rabbits were premedicated first with xylazine (Xylaject ® : 2% sol.…”
Section: Methodsmentioning
confidence: 99%